更新于：2024-11-01

Johnson & Johnson Consumer and Personal Products Worldwide

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更新于：2024-11-01

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项与 Johnson & Johnson Consumer and Personal Products Worldwide 相关的临床试验

NCT06479096 / CompletedN/A

Four-Week Oral Malodor and Clinical Safety for a Concentrated Cosmetic Mouthwash

The objective of this study is to evaluate the safety of the concentrated mouthwash prototypes, and to evaluate the efficacy of the concentrated mouthwash prototypes in the control of oral malodor compared to a comparator mouthwash and a negative control.

开始日期2024-07-15

申办/合作机构

Johnson & Johnson Consumer and Personal Products Worldwide

NCT03224403 / Completed临床3期

A Randomized, Double-Blind, Placebo- and Active- Controlled, Single-Dose, Efficacy and Safety Study of a Test Acetaminophen 500 mg Tablet in Postoperative Dental Pain

To evaluate analgesic onset, efficacy, and safety of 1000 mg acetaminophen administered as two Test Acetaminophen 500 mg tablets (Test ACM) compared with 1000 mg acetaminophen administered as two commercial acetaminophen 500 mg caplets (ACM) and 400 mg ibuprofen administered as two commercial ibuprofen 200 mg liquid-filled capsules (IBU) in the dental pain model following third-molar extractions.

开始日期2017-07-19

申办/合作机构

Johnson & Johnson Holdco (NA), Inc.

[+1]

NCT03213353 / Completed临床1期

A SingleDose Rand, TwoPeriod, Crossover Bioequivalence Study Between a Combination Tablet With Paracetamol, Guaifenesin and Penylephrine HCL (Wrafton Lab Ltd, UK) and Vicks Active SymptoMax Plus, Powder for Oral Solution (Wrafton Lab Ltd, UK) in Healthy Adult Volunteers

This is a single-dose, randomized, two-period cross-over study with 72 healthy male and female volunteers. The investigational products will be given (after fasting overnight) at separate visits separated by 7 ± 3 days. Blood for pharmacokinetic analyses will be drawn pre-dose and at 5, 10, 15, 20, 25, 30, 40, 60, 75, 90, 105 minutes, as well as 2, 2.25, 3, 4, 5, 6, 8, and 12 hours after drug administration. Subjects will also be monitored to capture any adverse events that may occur. Bioequivalence will be assessed based on the single-dose pharmacokinetics of paracetamol, guaifenesin and phenylephrine, respectively

开始日期2017-07-03

申办/合作机构

Johnson & Johnson Consumer and Personal Products Worldwide

100 项与 Johnson & Johnson Consumer and Personal Products Worldwide 相关的临床结果

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0 项与 Johnson & Johnson Consumer and Personal Products Worldwide 相关的专利（医药）

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项与 Johnson & Johnson Consumer and Personal Products Worldwide 相关的文献（医药）

2017-10-02·International Journal of Occupational and Environmental Health

Estimating infants’ and toddlers’ inhalation exposure to fragrance ingredients in baby personal care products

Article

作者: Hernandez, Marta ; Weisel, Clifford P ; Zhou, Jiaqi ; McCarthy, Timothy J ; Tierney, Neena K ; Black, Kathleen G

Fragrance ingredients are commonly added to many personal care products to provide a pleasant scent, including those intended for babies. While fragrance chemicals have a long history of safe use, at sufficiently high concentrations some may act as respiratory irritants or sensitizers. Little data have been reported on the inhalation exposures to fragrance compounds to infants and toddlers during bathing and lotion applications. This study demonstrates an in vitro method for measuring breathing zone air concentrations of fragrances from bath products and lotions. It employed simulated infant bathing and lotion application events and a robot to mimic a toddler's movement within a bathroom setting. The air concentrations in an infant's breathing zone were between <1 and 5 μg/m³ for each of seven common fragrance ingredients, while that in the breathing zone of toddlers in the bathroom was ≤ 1μg/m³. The air concentrations from the bathing additive were linearly related to their Henry's law constants and from the lotion inversely related to their octanol-air coefficients. The proposed approach can help refine risk estimates from inhalation exposure to fragrances used in baby products and guide future risk assessments of new products' safety for their use in baby bath products.

2016-09-01·Journal of Pharmaceutical and Biomedical Analysis3区 · 医学

Mechanism driven structural elucidation of forced degradation products from hydrocortisone in solution

3区 · 医学

Article

作者: Zhang, Fa ; Tavlarakis, Panagiotis ; Shi, Yiqun ; Zhou, Jay ; Karaisz, Kenneth

Hydrocortisone degradation products 1, 2, 3, and 4 along with hemiacetal derivatives 5, 6, 7, and 8 were observed through stressed hydrocortisone in solution. Their structures were identified based on HPLC-UV, HPLC-MS, and HPLC-HRMS (high resolution/high accuracy mass spectrometry) analyses as well as reaction mechanistic investigation and synthesis for structural confirmation. 1 and 2 are a pair of E/Z isomers and they were generated through acid catalyzed tautomerization/dehydration of hydrocortisone. Incorporation of water to 1 and 2 resulted in the formation of 3. We also discovered new degradation product 4 which was converted from 3 by oxidation. The degradation products were synthesized by stressing hydrocortisone under the optimized conditions and their structures were characterized by NMR ((1)H/(13)C, COSY, HMBC, HSQC, NOESY) and HRMS analyses. The degradation pathway of hydrocortisone is postulated.

2014-07-01·Tissue Engineering Part C: Methods4区 · 医学

A HumanIn VitroModel That Mimics the Renal Proximal Tubule

4区 · 医学

Article

作者: Kazanecki, Christian C. ; Hoppensack, Anke ; Schanz, Johanna ; Schenke-Layland, Katja ; Walles, Heike ; Gosiewska, Anna ; Colter, David

Human in vitro-manufactured tissue and organ models can serve as powerful enabling tools for the exploration of fundamental questions regarding cell, matrix, and developmental biology in addition to the study of drug delivery dynamics and kinetics. To date, the development of a human model of the renal proximal tubule (PT) has been hindered by the lack of an appropriate cell source and scaffolds that allow epithelial monolayer formation and maintenance. Using extracellular matrices or matrix proteins, an in vivo-mimicking environment can be created that allows epithelial cells to exhibit their typical phenotype and functionality. Here, we describe an in vitro-engineered PT model. We isolated highly proliferative cells from cadaveric human kidneys (human kidney-derived cells [hKDCs]), which express markers that are associated with renal progenitor cells. Seeded on small intestinal submucosa (SIS), hKDCs formed a confluent monolayer and displayed the typical phenotype of PT epithelial cells. PT markers, including N-cadherin, were detected throughout the hKDC culture on the SIS, whereas markers of later tubule segments were weak (E-cadherin) or not (aquaporin-2) expressed. Basement membrane and microvilli formation demonstrated a strong polarization. We conclude that the combination of hKDCs and SIS is a suitable cell-scaffold composite to mimic the human PT in vitro.

100 项与 Johnson & Johnson Consumer and Personal Products Worldwide 相关的药物交易

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100 项与 Johnson & Johnson Consumer and Personal Products Worldwide 相关的转化医学

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