An open label randomised control trial comparing between solo prednisolone therapy versus steroid-sparing agent along with daily doses of prednisolone in achievement of remission among FRNS and SDNS patients - NIL

开始日期2024-04-20

申办/合作机构

SCB Medical College & Hospital

100 项与 SCB Medical College & Hospital 相关的临床结果

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0 项与 SCB Medical College & Hospital 相关的专利（医药）

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102

项与 SCB Medical College & Hospital 相关的文献（医药）

2025-01-06·Laboratory Medicine

Navigating the conundrum of co-existing autoantibodies and alloantibodies in a case of Evans syndrome

Article

作者: Dash, Pallabi ; Pani, Nilasish ; Sahoo, Binay Bhusan ; Behera, Tusharkantee ; Panda, Jayant Kumar ; Mahapatra, Smita

2025-01-01·Transfusion Clinique et Biologique

Hyperbilirubinemia in Neonates with Blood Group Incompatibilities - a bane or a boon for the management

Article

作者: Panda, Swarupa ; Majhi, Madan Mohan ; Mahapatra, Smita ; Patra, Kaushik ; Behuria, Sasmita ; Sahoo, Pratima Kumari

OBJECTIVESNeonatal hyperbilirubinemia, or newborn jaundice, is a common condition caused by high bilirubin levels. Blood group incompatibility between mother and baby is a major cause. This study examined the link between different blood group incompatibilities and their management in newborns with jaundice.MATERIAL & METHODSThis prospective observational study included 190 neonates with hyperbilirubinemia requiring phototherapy. They were divided into two groups: control (blood group compatible) and case (blood group incompatible). Data on demographics, investigations, and management were collected.RESULTSBlood group incompatibility was present in 36.3% of cases, primarily ABO (28.9%). Rh incompatibility and ABO+Rh incompatibility accounted for 5.3% and 1.6%, respectively. DAT was positive in 32.7% of ABO incompatible cases, with anti-B more prevalent. Neonates with ABO incompatibility had the highest mean total serum bilirubin (TSB) level (13.04 mg/dL) and the largest overall decrease in TSB (-33.77%).The mean phototherapy duration was significantly longer in cases (44.1 hours) compared to controls (35.5 hours). ABO incompatible neonates had a longer average phototherapy duration (42.32 hours) compared to controls. However, ABO+Rh and pure Rh incompatible cases had highest phototherapy duration among cases. Moreover, within ABO cases, the mean phototherapy duration was higher in DAT-positive cases (46 hours) compared to DAT-negative cases (40.2 hours). Delivery mode, parity, and gender did not significantly influence phototherapy duration, but gestational age might play a role.CONCLUSIONVarious blood group incompatibilities, beyond RhD, are significantly associated with hyperbilirubinemia requiring phototherapy. ABO incompatibility was the most common cause. Neonatal jaundice is linked to blood group mismatch, with ABO+Rh and pure Rh incompatibility requiring longer phototherapy. However, ABO incompatible cases had longer phototherapy in comparison to controls. Gestational age might influence phototherapy duration.

2024-12-28·Panacea Journal of Medical Sciences

Prevalence of bacterial vaginosis, vulvovaginal candidiasis and trichomoniasis among pregnant women with special reference to chlamydial infection

作者: Hotta, Sasmita ; Priyanka, Kumari ; Khatua, Sasmita ; Majhi, Subasini ; Panigrahi, Kalpana ; Swain, Madhumita

Vaginal infections are a common problem among pregnant women and can lead to adverse pregnancy outcomes. This study aimed to investigate the prevalence of vaginal infections among symptomatic and asymptomatic pregnant women in Odisha, India.A total of 200 pregnant women aged 21-35 years attending the antenatal clinic of the Obstetrics and Gynaecology department were included in the study. A performa was prepared to collect data on patient history, personal hygiene, and associated comorbidities. Three high vaginal swabs and 2 ml of blood were collected from each patient and sent to the microbiology laboratory. The prevalence of vaginal infections was determined by analyzing the samples.Out of 200 samples processed, 30% were taken from symptomatic pregnant women and 70% were taken from asymptomatic pregnant women. The overall prevalence of vaginal infections was 59%. Vulvovaginal candidiasis (39%) was the most prevalent infection followed by bacterial vaginosis (30%). Mixed infection (VVC + BV) was found in 16% of the studied population. Chlamydial infection was found in 6% of the women. C. albicans (54%) was the predominant isolate, followed by C. tropicalis (28%). Adverse pregnancy outcomes noted in this study were preterm labor (5.9%) and premature rupture of membranes (2.54%). Vaginal infection had no significant association with adverse pregnancy outcome (P value = 0.971).This study highlights the high prevalence of vaginal infections among pregnant women in Odisha, India. The findings emphasize the need for routine screening and appropriate treatment of vaginal infections during pregnancy to prevent adverse pregnancy outcomes. Further studies with larger sample sizes and additional diagnostic methods are needed to confirm these findings.

100 项与 SCB Medical College & Hospital 相关的药物交易

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100 项与 SCB Medical College & Hospital 相关的转化医学

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