Study on metabolism and bioavailability of newly developed saccharide material, 1-deoxymannose, in humans - Study on metabolism and bioavailability of 1-deoxymannose in humans

开始日期2024-04-10

申办/合作机构

Nakamura Gakuen University

[+1]

JPRN-UMIN000053152 / RecruitingIIT

Effect of mulberry and water chestnut husk in mixed tea consumption on postprandial blood glucose levels in young adults: a randomized, double-blind, placebo-controlled crossover trial - Effect of mulberry and water chestnut husk in mixed tea consumption on postprandial blood glucose levels in young adults

开始日期2024-01-05

申办/合作机构

Nakamura Gakuen University

JPRN-UMIN000052418 / SuspendedIIT

Effects of drinking fruit juice beverages on mental stress in young women - Effects of drinking fruit juice beverages on mental stress

开始日期2023-10-09

申办/合作机构

Nakamura Gakuen University

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710

项与 Nakamura Gakuen University 相关的文献（医药）

2024-09-01·Journal of medical virology

Plasma vitamin D levels are correlated with the pathogenesis of human T-cell leukemia virus type 1-associated diseases.

Article

作者: Uchimaru, Kaoru ; Nakamura, Hitomi ; Sagara, Yasuhiro ; Yamano, Yoshihisa ; Sagara, Yasuko ; Miura, Kiyonori ; Matsuzaki, Koji ; Watanabe, Toshiki ; Shitsuta, Etsuko

The active form of vitamin D (VD) exerts hormonal effects by regulating the expression of genes involved in T-cell activity, cell differentiation, and proliferation. Human T-cell leukemia virus type 1 (HTLV-1) is a causative agent of life-threatening diseases, adult T-cell leukemia (ATL) and HTLV-1-associated myelopathy (HAM). Among ATL patients, hypercalcemia is one of the most serious complications due to bone resorption. In this study, wild-type mice administered UV-irradiated HTLV-1-infected cells showed up to 47% decrease of plasma VD level compared with untreated mice. To clarify the effect of HTLV-1 on plasma VD level, 315 samples registered in nationwide cohort study on ATL onset were measured. The VD level in HAM (14.98 ± 8.5 ng/mL) was significantly lower than those in asymptomatic carriers and ATL (p < 0.05). Upon comparing the VD levels in ATL stratified by disease subtypes, acute ATL showed a lower level (15.81 ± 12.0 ng/mL) than chronic and smoldering types (p < 0.05). In the longitudinal observation, VD levels were significantly higher in untreated spontaneous remission cases than in ATL progression cases, in which the VD levels decreased approximately 40% after onset. In cases of relapse after transplantation, the plasma VD level dropped to 38.7% of the pre-relapse level, while in cases of complete remission, the VD level increased with improvement of the performance status. Taken together, these results suggest that plasma VD level is a potential indicator for the onset and relapse of HTLV-1-associated diseases.

2024-05-02·Natural Product Research

Pentacyclic triterpene acids, rotungenic acid and barbinervic acid, from fresh leaves ofDiospyros kakiThunberg and their glutaminase inhibitory activities

Article

作者: Inagaki, Masanori ; Yamamoto, Kenta ; Kawabata, Kohei ; Shimada, Atsumi ; Ueno, Hiroshi

Glutaminase is an important target that is often over-expressed in neurodegenerative and lifestyle-related diseases but few effective inhibitors of this enzyme have yet reached clinical trials. Three compounds isolated from fresh leaves of Diospyros kaki Thunberg, ursolic acid (1), rotungenic acid (2) and barbinervic acid (3), were identified by analyzing their NMR and MS spectral data and comparison of these with reported data. The IC₅₀ values of 1-3 and 6-diazo-5-oxo-L-norleucine (DON) as control were 775, 13, 14, and 434 μM, respectively. Compounds 2 and 3 showed higher glutaminase inhibitory activities than DON. Compounds 2 and 3 may serve as potential lead compounds for the prevention and treatment of neurodegenerative and lifestyle-related diseases by targeting glutaminase. This is the first report on glutaminase inhibitory activities of 2 and 3.

2024-04-01·Journal of Atherosclerosis and Thrombosis

Association between an Antioxidant-Rich Japanese Diet and Chronic Kidney Disease: The Ohasama Study

Article

作者: Satoh, Michihiro ; Hara, Azusa ; Hirose, Takuo ; Oki, Tomoyuki ; Imai, Yutaka ; Watanabe, Jun ; Ohkubo, Takayoshi ; Murakami, Takahisa ; Tsubota-Utsugi, Megumi ; Metoki, Hirohito ; Takebayashi, Jun ; Asayama, Kei ; Kikuya, Masahiro ; Nomura, Kyoko ; Tsubono, Yoshitaka ; Hozawa, Atsushi ; Tatsumi, Yukako

AIMSAlthough physiological effects of hydrophilic- (H-) and lipophilic- (L-) antioxidant capacities (AOCs) are suggested to differ, the association of an antioxidant-rich diet and chronic kidney disease (CKD) incidence has not been examined. We therefore explored the association between the H- or L-AOC of a whole Japanese diet and CKD risk in a general population.METHODSA total of 922 individuals without CKD (69.2% women; mean age, 59.5 years old) from Ohasama Town, Japan, were examined. CKD incidence was defined as the presence of proteinuria and/or an estimated glomerular filtration rate (eGFR) of ＜60 ml/min/1.73 m². Consumption of H-/L-AOC was determined based on the oxygen radical absorbance capacity in a specially developed Japanese food AOC database. Hazard ratios (HRs) and 95% confidence intervals (CIs) were calculated for new-onset CKD using a Cox proportional hazards model.RESULTSDuring the median follow-up of 9.7 years, 137 CKD incidents were recorded. After adjusting for potential confounding variables, the highest quartile of L-AOC was significantly associated with a 51% reduced CKD risk among only women. An increased L-AOC intake was more effective in preventing eGFR reduction than in preventing proteinuria in women. These associations were not seen for H-AOC intake in both sexes and L-AOC intake in men.CONCLUSIONSA high intake of lipophilic antioxidants may be associated with a reduced CKD risk. The balance between dietary antioxidant intake and pro-oxidants induced by unhealthy lifestyles may be crucial for preventing future kidney deterioration.

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