Delving into the Latest Updates on Sahrdaya College of Engineering & Technology with Synapse

概览

疾病领域	数量

肿瘤	1

排名前五的药物类型	数量

小分子化药	1

排名前五的靶点	数量

EGFR(表皮生长因子受体erbB1)	1

关联

1

项与 Sahrdaya College of Engineering & Technology 相关的药物

EGFR Inhibitors(Sahrdaya College of Engineering and Technology)

靶点

EGFR

作用机制

EGFR拮抗剂

在研机构

Sahrdaya College of Engineering & Technology

原研机构-

在研适应症

结直肠癌

非在研适应症-

最高研发阶段药物发现

首次获批国家/地区-

首次获批日期-

100 项与 Sahrdaya College of Engineering & Technology 相关的临床结果

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0 项与 Sahrdaya College of Engineering & Technology 相关的专利（医药）

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119

项与 Sahrdaya College of Engineering & Technology 相关的文献（医药）

2025-04-11·Current Topics in Medicinal Chemistry

Prediction and Validation of Novel BRAF Inhibitor as a Potential Drug Candidate for the Treatment of Colorectal Cancer

Article

作者: Joy, Amitha ; Valavi, Sudha George ; K, Amrutha Krishnan

Background:Colorectal cancer (CRC), the world's third leading cause of death, can be caused by a variety of reasons, one of which is a valine-to-glutamate mutation at position 600 in the BRAF gene. Nonetheless, the prognosis of patients with BRAF mutations remains poor, necessitating additional research in this field.Objective:This work aims to recognize and validate innovative and effective BRAF inhibitors.Methods:A merged-featured ligand-based pharmacophore model was validated and screened against various external databases. The pharmacokinetic and toxicological characteristics of the 102 hits were analyzed, and the appropriate ligands were docked against BRAF protein. The top four protein-ligand complexes with the lowest binding energies were chosen, and their molecular dynamic (MD) simulation studies were accomplished.Results:The finest complex selected has a Root Mean Square Deviation (RMSD) value of 2.229A0 and a Radius of gyration (RoG) value of 25.770A0. The LC50 of the best ligand was experimentally calculated to be 102.83 μg/ml. The ligand was found to destroy CRC cells, but it did not affect normal non-cancerous cells much.Conclusion:This work thus proposes 3-(6,7-dimethoxy-3,4-dihydroisoquinoline-2-carbonyl)-N- (2-methoxyphenyl)benzenesulphonamide as a potential BRAF V600E inhibitor for the CRC treatment.

2025-03-04·Journal of Electromagnetic Waves and Applications

Beam steering of Fabry Pérot antenna by using hybrid metasurfaces

作者: Antony, Anett ; Dasgupta, Bidisha

2025-03-04·2025 International Conference on Visual Analytics and Data Visualization (ICVADV)

Enhanced Real-Time Pothole Detection Using YOLOv8 with EfficientNet Backbone: A Deep Learning Approach for Road Safety

作者: George, Riya ; Francis, Ambiliy ; Devassy, Binet Rose

100 项与 Sahrdaya College of Engineering & Technology 相关的药物交易

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100 项与 Sahrdaya College of Engineering & Technology 相关的转化医学

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