1区 · 医学
Article
作者: Johnstone, Ricky W ; Sornkom, Jirawas ; Hannan, Katherine M ; Wei, Andrew ; Pearson, Richard B ; Rozario, James D ; Pitson, Stuart M ; Sanij, Elaine ; Diesch, Jeannine ; Pavy, Megan ; Cameron, Donald P ; Fong, Chun Yew ; Quin, Jaclyn ; Dawson, Mark A ; Hein, Nadine ; Cullinane, Carleen ; Verbrugge, Inge ; Hannan, Ross D ; Nguyen, Nhu-Y N ; Powell, Jason A ; Devlin, Jennifer R ; Poortinga, Gretchen ; Wall, Meaghan ; Drygin, Denis ; McArthur, Grant A ; Baker, Adele ; Guthridge, Mark A ; Harrison, Simon J ; George, Amee J ; Zuber, Johannes
Key Points:Inhibition of RNA Pol I by CX-5461 treats aggressive AML and outperforms standard chemotherapy regimens. CX-5461 induces p53-dependent apoptosis, p53-independent cell-cycle defects and differentiation, and reduces LICs.