Alcalingua Universidad de Alcala SRL

Do you celebrate your birthday in the same month as your mum?  If so, you are not alone. The phenomenon occurs more commonly than expected -- a new study of millions of families has revealed.  Do you celebrate your birthday in the same month as your mum? If so, you are not alone. The phenomenon occurs more commonly than expected -- a new study of millions of families has revealed. Siblings also tend to share month of birth with each other, as do children and fathers, the analysis of 12 years' worth of data shows, whilst parents are also born in the same month as one another more often than would be predicted. Previous research has found that women's season of birth somehow influences that of their children. But this research, published today in the peer-reviewed journal Population Studies, is the first to show that women are more likely to have children in the same month as their own birth. The researchers from Spain and the US analyzed official data on more than 10 million births. They looked all births in Spain from 1980 to 1983 and from 2016 to 2019 and all births in France from 2000 to 2003 and from 2010 to 2013. The records provided the child's month of birth, as well as those of their parents and the sibling that was closest to them in age. Births in a particular country tend to follow a pattern, with more babies being born at certain times of the year than at others. This is known in academic literature as birth seasonality. But when the researchers divided the birth data into groups based on the month of birth of the mothers, the births didn't follow the expected pattern. Instead, there was a spike in January births among the mothers who were born in January, a spike in February babies in the mothers who were born in February and so on. Overall, there were 4.6% more births in which mother and child shared the same birth month than would be expected. This was true for both countries and all four time periods studied. It was also the case for siblings (there were 12.1% more births than expected in which adjacent siblings had the same month of birth), parents with the same month of birth (4.4% more births) and when a child had the same birth month as their father (2% more births). A second, less detailed, analysis of all the births in Spain from 1980 to 2019 and all births in France from 2000 to 2019, confirmed the result. The phenomenon likely has its roots in relatives sharing socio-demographic characteristics: people of similar backgrounds are known to pair up and to be more likely to give birth at certain times of the year, say researchers Dr. Adela Recio Alcaide, of the University of Alcalá in Spain, and Professor Luisa N. Borrell, of the City University of New York in the United States. In Spain, for example, a woman with a higher education is more likely to give birth in the spring than woman without a higher education. If she has a daughter, in addition to being more likely to be born in the spring, this daughter may be more likely to have higher education, since her mother has it. And thus, when this daughter has children, she will be more likely to have them in the spring too. That is, this daughter will be more likely to have children in the same season in which she was born because she has kept her family sociodemographic characteristics -- specifically the higher education- which make her more likely to give birth at a given time -- spring -- and, as a result, the season -- and even month -- of birth is passed between the generations. Factors that can affect the biology of fertility, such as availability of food and exposure to sunlight, can also vary according to a person's background. "What could cause the higher probabilities of family members being born in the same season? The potential explanations seem to be both social and biological," states Dr. Adela Recio Alcaide, an epidemiologist at the University of Alcala. "The excess of children with a father and mother born in the same month seems to be due to social or behavioral causes prior to conception that relate to the choice of a partner born in the same month, as we have observed this excess with marriage statistics, with spouses being more likely to mate with someone from the same month." "This," adds co-author Professor Luisa Borrell, from The City University of New York, "may not be surprising considering things such as partnerships tend to be formed by people with similar socio-demographic characteristics." "Moreover, biological factors that are known to affect birth seasonality -- such as photoperiod exposure, temperature, humidity, and availability of food -- also depend on socio-demographic characteristics, since different social groups are exposed to these biological factors to varying degrees," Professor Borrell, a social epidemiologist at the City University's Department of Epidemiology & Biostatistics, Graduate School of Public Health & Health Policy, says. The study's strengths include the large number of births included in the analysis and the inclusion of data from different decades and different countries. However, one limitation is that the analysis assumes an "independence of outcomes but that might not be the case and, therefore, dependence of the outcomes within families may have affected findings." To adjust for this, the team repeated their analyses to account for dependency of outcomes within families and the results were very similar to those presented. While this is a novel finding, further research is needed to confirm and deepen the results and their implications. Concluding, the authors outline the importance that the link between family characteristics and birth month is considered in any future research into how a child's month of birth affects their health, educational and other outcomes.

NEW ORLEANS, July 14, 2020 (GLOBE NEWSWIRE) -- South Rampart Pharma, LLC ("South Rampart" or "the Company"), a company committed to improving the lives of people suffering from pain by developing a new class of non-opioid pain medicines, today announced a peer-reviewed publication detailing the identification and characterization of a new class of compounds able to reduce pain and fever without abuse potential or the liver and kidney toxicity associated with over the counter pain medicines such as acetaminophen. The paper, published in the European Journal of Medicinal Chemistry, is available as open access and entitled, "A novel pipeline of 2-(benzenesulfonamide)-N-(4-hydroxyphenyl) acetamide analgesics that lack hepatotoxicity and retain antipyresis1." “We are currently working to finalize the preclinical data package necessary to submit our lead molecule for the first Investigational New Drug (IND) application by the third quarter of 2020, followed by the rapid initiation of Phase 1 clinical trials to evaluate safety. Ongoing preclinical studies have reproduced these extensive proof of concept studies confirming that our lead compound shows pain reduction with absent liver and kidney toxicity,” said Dr. Hernan A. Bazan, chief executive officer and co-founder of South Rampart. “Our primary goal is to develop and commercialize new alternative pain medications that lack abuse potential and have fewer associated safety concerns than current treatment options.” The paper characterizes the synthesis and screening of a library of compounds, including two compounds with the ability to reduce both pain and fever. Moreover, these compounds do not cause liver or kidney toxicity, as is the case with common over the counter medicines such as acetaminophen. Lastly, the molecular mechanism that accounts for the lack of liver toxicity is demonstrated in this publication. The chemical synthesis of this new class of compounds was performed in collaboration with researchers at the LSUHSC School of Medicine in New Orleans and the University of Alcala in Madrid, Spain. About Chronic Pain Acute and chronic pain affect more than 50 million Americans and is one of the most prevalent and costly public health issues worldwide. For example, pain costs the U.S. healthcare system an estimated $635 billion each year creating an enormous unmet need for safer pain relief2. Current medications are either highly addictive or cause harm to the liver or kidney with overuse creating a significant unmet need for new safe, effective and non-opioid pain medications. About South Rampart Pharma South Rampart Pharma is committed to improving the lives of people suffering from acute, chronic or neuropathic pain by developing a new class of small molecule, non-opioid pain medicines. ­­South Rampart Pharma’s proprietary compounds have been effective in reducing both pain and fever in pre-clinical studies without liver and kidney toxicity, that are associated with current common over the counter analgesics. Headquartered in New Orleans, South Rampart Pharma is working with top medicinal chemists across the United States and in Spain at clinical and academic research centers to develop oral and intravenous formulations optimized for each indication. For more information, please visit . South Rampart Pharma, LLC Contact: Hernan A. Bazan, MD, DFSVS, FACS CEO and Co-Founder info@southrampartpharma.com References: 1. Bazan, H.A., et al. A novel pipeline of 2-(benzenesulfonamide)-N-(4-hydroxyphenyl) acetamide analgesics that lack hepatotoxicity and retain antipyresis. Eur J Med Chem202, 112600 (2020). 2. DJ, G. & P, R. The Economic Costs of Pain in the United States. The journal of pain : official journal of the American Pain Society13(2012).