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项与 Nippon Hypox Laboratories Inc. 相关的药物

HX-1171

靶点

Nrf2

作用机制

Nrf2刺激剂

在研机构-

原研机构

Nippon Hypox Laboratories Inc.

在研适应症-

非在研适应症

动脉粥样硬化 [+5]

最高研发阶段终止

首次获批国家/地区-

首次获批日期-

HX-0836

靶点

5-LOX x COX-2

作用机制

5-LOX抑制剂 [+1]

在研机构-

原研机构

Nippon Hypox Laboratories Inc.

在研适应症-

非在研适应症

超敏反应 [+1]

最高研发阶段无进展

首次获批国家/地区-

首次获批日期-

100 项与 Nippon Hypox Laboratories Inc. 相关的临床结果

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0 项与 Nippon Hypox Laboratories Inc. 相关的专利（医药）

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6

项与 Nippon Hypox Laboratories Inc. 相关的文献（医药）

2010-02-18·Journal of Pharmacy and Pharmacology3区 · 医学

1-0-Hexyl-2,3,5-trimethylhydroquinone inhibits IκB phosphorylation and degradation-linked inducible nitric oxide synthase expression: beyond antioxidant function

3区 · 医学

Article

作者: Nishikawa, Hiroshi ; Itoigawa, Masataka ; Miki, Tokutaro ; Ishikawa, Naohisa ; Sugiyama, Satoru ; Liu, Wei

AbstractInducible nitric oxide (NO) production in macrophages plays an important role in atherosclerosis, the protective effects of vitamin E and its derivatives perhaps being partly mediated by alteration in this parameter. We have investigated the influence of a novel synthesized vitamin E derivative, 1-0-hexyl-2,3,5-trimethylhydroquinone (HTHQ), on NO production in the RAW 264.7 mouse macrophage cell line. HTHQ dose-dependently inhibited lipopolysaccharide (LPS)-induced NO production through reducing LPS-triggered inducible nitric oxide synthase (iNOS) expression. The phosphorylation and subsequent degradation of IKB caused by LPS in RAW 264.7 cells was markedly blocked. The free radical scavenging activity of HTHQ was only 2-fold that of vitamin E, whereas its inhibition of NO production was found to be nearly 500-fold stronger. Our results indicated that HTHQ suppressed NO production in macrophages by blocking IKB degradation and thus inhibiting iNOS expression. The inhibitory activity of HTHQ on NO production did not parallel its free radical scavenging activity, implying a possible involvement of additional functions.

Oyo Yakuri

Reproduction study on elcatonin (1). Fertility study in rats

作者: Yamamoto, Hiroshi ; Kobayashi, Yoshiro ; Kitajima, Shogo ; Koda, Shigeru

Elcatonin [60731-46-6], an analog of calcitonin, was injected i.v. into male rats daily for 63 days and into female rats daily for 14 days prior to mating.Treatment was continued in the female rats until day 7 of pregnancy.The doses were 4, 40, and 160 units/kg/day.The medium and high doses of elcatonin caused a decrease in body weight gain and a transient decrease in food intake in both male and female rats.However, elcatonin did not affect fertility or reproductive performances such as mating, impregnation, and pregnancy.Neither internal nor skeletal examination revealed any effect of elcatonin on fetal development.From these results, the maximum no-effect dose of elcatonin is estimated at 4 units/kg/day for the phys. condition of the parent rats and 160 units/kg/day for reproductive function and fetuses.

Japanese Journal of Antibiotics

Reproduction study on rokitamycin. Teratological study in rabbits

作者: Hayano, Kazuo ; Kitajima, Shogo ; Koda, Shigeru ; Kobayashi, Yoshiro

The teratogenicity of rokitamycin (TMS-19-Q) was studied in rabbits.TMS-19-Q was orally administered at 100, 300, and 600 mg/kg from day 6 to day 18 of gestation.Diarrhea and decrease in body weight gain and food consumption were observed in dams at >300 mg/kg.A decrease in the number of live fetuses was observed at >300 mg/kg, but there was no teratogenicity at any dose level.The maximum nontoxic dose for TMS-19-Q was 100 mg/kg.

100 项与 Nippon Hypox Laboratories Inc. 相关的药物交易

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100 项与 Nippon Hypox Laboratories Inc. 相关的转化医学

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