Rhone-Poulenc Rorer, Inc.

After more than 15 years serving on AnaptysBio’s Board of Directors, Jamie Topper, M.D., Ph.D., is stepping down and will serve as an advisor to the Board through Q1 2024 SAN DIEGO, Sept. 18, 2023 (GLOBE NEWSWIRE) -- AnaptysBio, Inc. (Nasdaq: ANAB), a clinical-stage biotechnology company focused on delivering innovative immunology therapeutics, today announced it has appointed John Orwin chairman of the AnaptysBio Board of Directors. “We are excited to welcome John to Anaptys’ Board of Directors as chairman. With more than 25 years of diverse experience across the biopharmaceutical landscape, John brings a track record of substantial accomplishment across our sector as a biotech CEO and Board member. We welcome John’s guidance and expertise in later-stage drug development, commercial planning and overall corporate strategy as we focus on broadly developing our differentiated immune cell modulators, including our two checkpoint agonists, in autoimmune and inflammatory diseases,” said Daniel Faga, president and chief executive officer of AnaptysBio. “We thank Jamie for his many years of service to the Board and his partnership over the past year as we successfully refocused our strategy on diseases with clear biology supporting immune cell modulation, high unmet need and large commercial potential.” Currently, Mr. Orwin serves on the Board of Directors of Seagen, Inc., Travere Therapeutics and Cargo Therapeutics. He previously served on the Board of Directors of Array BioPharma, Inc. Mr. Orwin also currently serves as president and CEO of Atreca, Inc., a clinical-stage biotechnology company, and previously was the CEO of Relypsa, until its acquisition by Galenica, and CEO of Affymax. In building successful businesses and commercializing a range of blockbuster products, he has held leadership roles in marketing, sales and operations for Genentech, Johnson & Johnson, Alza Pharmaceuticals, Sangstat Medical Corporation, Rhone-Poulenc Rorer and Schering-Plough Corporation. Mr. Orwin holds a master’s degree in business administration from New York University and a bachelor’s degree from Rutgers, The State University of New Jersey. “It is an incredibly exciting time at Anaptys as they advance their portfolio of novel, best-in-class immune cell modulators to treat diseases including rheumatoid arthritis and atopic dermatitis,” said Mr. Orwin. “Anaptys is advancing the field of immunology and inflammation with a high level of executional excellence, expertise and commitment. I’m honored to work collaboratively with this Board and leadership team that is inspired by and committed to its vision to transform patient health by delivering innovative immunology therapeutics.” Dr. Topper has served on the AnaptysBio Board of Directors since 2007 and as chairman since 2015. During this tenure, he has overseen the evolution of AnaptysBio from an early-stage antibody generation platform to a clinical-stage organization. Dr. Topper will remain in a transitionary role as an advisor to the Board through Q1 2024. “It has been an honor to serve on this dynamic Board of Directors. I leave knowing that the Board and company are in good hands as they embark on the next stage of development,” said Dr. Topper. “I look forward to supporting John, Dan, the Board and the rest of the team in a transitionary capacity as well as following the Anaptys story as they focus on the development of their immune cell modulator portfolio, an exciting new frontier in the area of medicine.” About AnaptysBio AnaptysBio is a clinical-stage biotechnology company focused on delivering innovative immunology therapeutics. It is developing immune cell modulators, including two checkpoint agonists in clinical-stage development, for autoimmune and inflammatory disease: rosnilimab, its PD-1 agonist, in a planned Phase 2b trial for the treatment of moderate-to-severe rheumatoid arthritis; and ANB032, its BTLA agonist, currently in a Phase 2b trial for the treatment of moderate-to-severe atopic dermatitis. Its preclinical immune cell modulator portfolio includes ANB033, an anti-CD122 antagonist antibody for the treatment of autoimmune and inflammatory diseases. In addition, AnaptysBio has developed two cytokine antagonists available for out-licensing: imsidolimab, an anti-IL-36R antagonist, in Phase 3 for the treatment of generalized pustular psoriasis, or GPP, and etokimab, an anti-IL-33 antagonist for the treatment of respiratory disorders that is Phase 2/3 ready. AnaptysBio has also discovered multiple therapeutic antibodies licensed to GSK in a financial collaboration for immune-oncology, including an anti-PD-1 antagonist antibody (Jemperli (dostarlimab-gxly)), an anti-TIM-3 antagonist antibody (cobolimab, GSK4069889) and an anti-LAG-3 antagonist antibody (GSK4074386). Forward-Looking Statements This press release contains forward-looking statements within the meaning of the "safe harbor" provisions of the Private Securities Litigation Reform Act of 1995, including, but not limited to: whether any of the Company’s products will be best in class; and the company’s ability to find a licensing partner for imsidolimab or etokimab and the timing of any such transaction. Statements including words such as “plan,” “continue,” “expect,” or “ongoing” and statements in the future tense are forward-looking statements. These forward-looking statements involve risks and uncertainties, as well as assumptions, which, if they do not fully materialize or prove incorrect, could cause its results to differ materially from those expressed or implied by such forward-looking statements. Forward-looking statements are subject to risks and uncertainties that may cause the company’s actual activities or results to differ significantly from those expressed in any forward-looking statement, including risks and uncertainties related to the company’s ability to advance its product candidates, obtain regulatory approval of and ultimately commercialize its product candidates, the timing and results of preclinical and clinical trials, the company’s ability to fund development activities and achieve development goals, the company’s ability to protect intellectual property and other risks and uncertainties described under the heading “Risk Factors” in documents the company files from time to time with the Securities and Exchange Commission. These forward-looking statements speak only as of the date of this press release, and the company undertakes no obligation to revise or update any forward-looking statements to reflect events or circumstances after the date hereof. Contact: Nick Montemarano Senior Director, Investor Relations and Strategic Communications AnaptysBio, Inc. 858.732.0178 investors@anaptysbio.com

-- New $3.8 million DOD contract extension will fund non-clinical safety studies to support a three-month seasonal prophylaxis Phase 2b study in at-risk populations, comprising elderly individuals with comorbidities, including chronic lung diseases and diabetes. -- ENA Respiratory names new clinical leaders and consultants to accelerate and optimize its research and development program. SYDNEY, Australia, Aug. 29, 2023 (GLOBE NEWSWIRE) -- Clinical-stage pharmaceutical company ENA Respiratory has been awarded an additional $3.8 million contract from the U.S. Department of Defense (DOD) to support ongoing research and development of INNA-051, a first-in-class, intranasal, innate immune modulator for the prevention of complications associated with respiratory viral infections in at-risk populations. The company also announced new clinical leadership and consultants as it plans for a seasonal prophylaxis Phase 2b study. The new funding adds to the $4.38 million initial DOD funding the company announced in January 2023, which has been used to implement INNA-051 manufacturing on a larger scale. The funds also supported the development of a dry powder formulation that is expected to provide long-term stability of at least 24 months at room temperature. The new funding will support the non-clinical toxicology and safety studies needed to enable a seasonal prophylaxis Phase 2b study to demonstrate the safety, tolerability, and efficacy of intranasal INNA-051 in preventing respiratory illness in people aged 65 or older. “Early studies validated the safety of INNA-051 and provided proof of pharmacology by accelerating virus clearance and boosting host defense responses against common respiratory viruses,” said Christophe Demaison, Ph.D., co-founder and CEO of ENA Respiratory. “We are grateful for the U.S. DOD support and look forward to continuing to study INNA-051 in preventing respiratory illnesses, especially in those at greatest risk of exposure, complications, or hospitalization.” The contract was awarded by the DOD’s Joint Program Executive Office for Chemical, Biological, Radiological and Nuclear Defense (JPEO-CBRND), Joint Project Manager for Chemical, Biological, Radiological, and Nuclear Medical in collaboration with the Defense Innovation Unit (DIU). ENA Respiratory Names Expanded Clinical Leadership The company also announced new leadership and consultants to accelerate and optimize its research and development program. Ruth Tal-Singer, Ph.D., joins as Medicine Development Leader to oversee all clinical development efforts. Previously, Dr. Tal-Singer was a Consultant and Board Member for ENA Respiratory. She is an internationally recognized scientist with extensive experience in molecular biology, immunology, and application of digital technology and in vivo disease models in clinical development. Most recently, she served as President and CEO of the COPD Foundation, where she launched the Foundation’s digital health, medical devices, and therapeutics development accelerator network, COPD360Net®, and championed its partnership with ENA Respiratory. Her efforts to ensure the patient voice is central to lung disease therapeutics development continue in her volunteer role as Chief Scientific Officer of the Global Allergy and Airways Patient Platform (GAAPP). Earlier in her career, she served in senior leadership roles at GSK R&D. Courtney Crim, M.D., joins as Clinical Consultant and acting Chief Medical Officer. He also serves as Clinical Associate Professor of Medicine in the Division of Pulmonary and Critical Care Medicine at the University of North Carolina in Chapel Hill. Previously, he was Group Director in Clinical Development in Respiratory Clinical Sciences at GSK, designing Phase 2-4 clinical trials. He has also served on the FDA Pulmonary and Allergy Drug Advisory Committee and presented drug approval submissions to U.S., European, and other regulatory agencies. Bruce Miller, Ph.D., joins as a Clinical Consultant with more than 30 years of experience developing therapies for COPD and other inflammatory-driven diseases. He has previously served in senior scientific roles at GSK, Johnson & Johnson, Rhone-Poulenc Rorer, and Sterling Winthrop Pharmaceuticals. Active in the industry, he previously served as co-chair of the COPD Foundation’s COPD Biomarker Qualification Consortium’s Fibrinogen Working Group, which was instrumental in gaining regulatory qualification for a biomarker as a drug development tool in COPD trials. “Our accomplished team brings decades of experience leading clinical research programs for respiratory diseases and successfully submitting new therapies for regulatory approvals in the U.S., Europe, and other regions,” said Dr. Demaison. “With these additions to our team, we are well-positioned to continue the clinical development of INNA-051 in the context of natural respiratory tract infections in individuals with increased risk of severe illness or exposure.” Effort sponsored by the U.S. Government under Other Transaction number HQ0845-23-9-0003 between ENA Respiratory Pty Ltd and the U.S. Government. The U.S. Government is authorized to reproduce and distribute reprints for Governmental purposes, notwithstanding any copyright notation thereon. The views and conclusions contained herein are those of the authors and should not be interpreted as necessarily representing the official policies or endorsements, either expressed or implied, of the U.S. Government. Notes to Editors If you would like to arrange an interview, please contact: Glenn Silver, FINN Partners, +1 973 818 8198, glenn.silver@finnpartners.com About ENA Respiratory ENA Respiratory is aiming to transform the prevention of complications associated with respiratory viral infections in populations at-risk of complications. The company is based in Melbourne and Sydney, Australia, and it has secured a Series A investment from Brandon Capital Partners’ managed funds, the Minderoo Foundation, and Uniseed. In 2022, ENA Respiratory partnered with the US-based COPD Foundation to accelerate the clinical development of INNA-051 in COPD through its access to patients, a global network of accredited centres, scientific expertise, and patient investigators. That year, the company was also the first in the Asia Pacific region to be selected to join BLUE KNIGHT™, a joint initiative between Johnson & Johnson Innovation and U.S. BARDA. In 2023, the company was additionally awarded a USD $4.38 million contract from the U.S. Department of Defense to support ongoing development of INNA-051. About INNA-051 INNA-051 is a potent innate immune TLR2/6 agonist. It is being developed for intranasal delivery to target the primary entry site of viral respiratory infections as most respiratory viruses, including SARS-CoV-2, Human Rhinovirus, RSV, and influenza, initially infect and replicate in nasal mucosa epithelial cells. By targeting protective host defense mechanisms that are virus agnostic and through its simple route of administration, INNA-051 has the potential to address a major unmet need in at-risk populations. It also has the potential to be rapidly deployed and complement vaccine and direct-acting antiviral efforts in the battle against current and future respiratory virus outbreaks, including COVID-19. In a Phase IIa influenza-challenge study, INNA-051 was found to accelerate virus clearance and boost host responses against influenza virus, including interferon responses. The human data confirmed pre-clinical data in human airway epithelial cells as well as rhinovirus, influenza, and COVID-19 animal infection models. INNA-051 is well-tolerated in humans at single and repeat doses. Key features of INNA-051 intranasal administration include minimal systemic bioavailability, durable immune response (supporting weekly administration), and compatibility with available vaccines and corticosteroids. Importantly, INNA-051 activity is not significantly affected by senescence (inflammaging), and its safety profile supports prophylaxis use. For more information, please visit https://enarespiratory.com

– Board of Director appointments follow the Company’s recent launch and $200 million Series A financing in March 2023 – – Appointments include industry veterans John Orwin as Chairman, David Lubner as Independent Director and Strategic Finance and Audit Committee Chair, and Dr. Krishnan Viswanadhan as Independent Director – SAN MATEO, Calif., Aug. 24, 2023 (GLOBE NEWSWIRE) -- CARGO Therapeutics, Inc. (CARGO), a clinical-stage biotechnology company uniquely positioned to advance next generation CAR T-cell therapies designed to provide hope for a cure for more cancer patients, today announced the addition of independent directors to the Board of Directors following its recent $200 million Series A financing in March 2023. The Board brings together an esteemed group of experienced life science leaders with expertise spanning finance, business operations, drug discovery and clinical development, including experts and pioneers in CAR T-cell therapies and oncology. “I am honored to formally announce our Board of Directors—preeminent life science leaders with significant operational experience who will partner closely with our leadership team to contribute meaningfully to our mission and vision to build a company that is uniquely positioned to develop next generation CAR T-cell therapies that provide hope of better outcomes and potentially a cure for more patients with cancer,” said Gina Chapman, CARGO's President and Chief Executive Officer. The most recent board appointments include John Orwin as Chairman of the Board, David Lubner as Independent Director and Strategic Finance and Audit Committee Chair, and Krishnan Viswanadhan, PharmD, as Independent Director. “It is an incredibly exciting time to work closely with the CARGO team as they prepare to begin a Phase 2 pivotal study and advance their pipeline of CAR T-cell therapies,” said Mr. Orwin. “CARGO is building on the learnings from previous cell therapies and is poised to meaningfully advance the cell therapy field with a high level of executional excellence, expertise and passion. I’m honored to work with this Board and leadership team that is inspired by and committed to the mission to deliver more cures to patients.” John Orwin, CEO and President of Atreca Therapeutics, has over 30 years of diverse experience in the biotechnology and pharmaceutical industries, having held senior positions at leading pharmaceutical and biotechnology companies, including Johnson & Johnson, Affymax, Rhone-Poulenc Rorer, Genentech and Relypsa. Mr. Lubner added, “Following a successful Series A financing earlier this year that included a syndicate of leading biotechnology investors, CARGO continues to make significant operating progress. The team’s dedication to cutting-edge research and development, and a deep commitment to patient-centricity makes me proud to be a part of their journey of bringing urgently needed CAR T-cell therapies to patients with cancer.” Mr. Lubner serves on several public and private company Boards of Directors, including Arcellx, Dyne Therapeutics, Point Biopharma and Vor Biopharma. He has extensive experience raising capital in private and public markets and has led various deal-related transactions and corporate partnerships/alliances. He has a proven capability in building and leading finance, operations and corporate development functions. “Large B-cell lymphoma is the most common aggressive lymphoid malignancy in the United States and Europe. While CD19 CAR T-cell therapies can induce long-term remission in some patients, the challenges in treating the 60% of LBCL patients who do not experience durable responses to CD19 CAR T-cell therapies are significant,” said Dr. Viswanadhan. “I look forward to playing a role in advancing another CAR T-cell therapy to reach more patients.” Dr. Viswanadhan has over 20 years of broad cross-functional biopharma experience. He is currently President and COO at Be Biopharma, and previously held leadership roles at Bristol Myers Squibb and Celgene Corporation. During his time at BMS, he oversaw the teams responsible for the development, approval and life cycle management of commercial CAR T therapies. Additional members of the CARGO Board of Directors are listed below; full bios are available on the CARGO website. Abraham Bassan, Principal, Samsara BioCapitalGina Chapman, President and Chief Executive Officer, CARGO TherapeuticsGianna Hoffman-Luca, PhD, Principal, XontogenyReid Huber, PhD, Partner, Third Rock VenturesHeath Lukatch, PhD, Founder and Managing Partner, Red Tree Venture CapitalCrystal Mackall, MD, Ernest and Amelia Gallo Family Professor of Pediatrics and Medicine, Stanford University. Co-Founder, CARGO Therapeutics. About CARGO Therapeutics CARGO Therapeutics is developing next generation chimeric antigen receptor (CAR) T-cell therapies to outsmart cancer. Our lead clinical program, CRG-022, is preparing to enter a potentially pivotal Phase 2 clinical study.. Our proprietary platform technologies enable us to engineer and develop next generation CAR Ts with the potential to achieve durable responses and reliable supply that have the potential to be curative for more cancer patients. Our founders are pioneers and world experts in CAR T-cell therapy, and our team has experience and success developing, manufacturing, launching and commercializing oncology and cell therapy products. For more information, please visit the CARGO Therapeutics website at https://cargo-tx.com/. Find more information at cargo-tx.comFollow us on LinkedIn: CARGO TherapeuticsFollow us on Twitter: @CARGOTx Media Contact:Maura Gavaghanmaura@redhousecomms.com Investor Contact:Laurence Wattslaurence@gilmartinir.com