More than half of the Dutch population is overweight or obese, which is associated with an increased risk of COVID-19 and worse outcomes during a COVID-19 infection. In addition, malnutrition and loss of muscle mass are often reported with COVID-19, as well as with cancer and other diseases. Malnutrition and overweight or obesity can coexist, even within the same individual. It is still unclear which mechanisms contribute to the worse outcomes of COVID-19 and other diseases in case of overweight, malnutrition, and a combination of both. The aim of this study is to identify which parameters are associated with worse disease outcomes through literature research and database research (COVID-19 and cancer, more than 150.000 participants). In addition, a clinical study will be conducted aiming to develop a simple screening tool for the recognition of the coexistence of malnutrition and overweight or obesity in clinical practice.

开始日期2024-10-02

申办/合作机构

HAN University of Applied Sciences

[+4]

NCT07036341

/ RecruitingN/AIIT

Rehabilitation After a Hip Fracture: the Effects of Dietary Protein and Exercise on Bone and Muscle Health and Quality of Life

Hip fractures often lead to functional limitations, loss of independence, weight loss and decreased well-being. Only half of the patients regain their functional level and 24% die within the following year. Financial consequences are significant due to costly surgery and long-term care. Hip fracture incidence is expected to increase sharply due to the ageing population, reducing accessibility to and quality of rehabilitation care. Therefore, optimizing treatment is essential.
Previous protein and exercise studies showed improved muscle and bone health in healthy or frail community-dwelling older adults, but effects in older hip fracture patients are not known. Better rehabilitation may improve bone and muscle health, nutritional status, quality of life, lower costs and lower burden for healthcare.
The overall objective is to investigate the effectiveness, costs and cost-effectiveness of a protein-enriched diet and resistance exercise for 3 months compared to usual care on bone and muscle health, and quality of life in older adults recovering from an acute hip fracture.

开始日期2024-09-01

申办/合作机构

Wageningen University

[+3]

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705

项与 HAN University of Applied Sciences 相关的文献（医药）

2026-02-01·Intensive and Critical Care Nursing

Refining the understanding of ICU Nurses’ attitudes towards family involvement: Key methodological, conceptual, contextual, and statistical considerations – Response to Bahramnezhad et al.

Letter

作者: Rood, Paul J T ; Jonkman, Nini H ; Paulus, Frederique ; Eskes, Anne M ; Verkaik, Isha

2025-12-01·TRENDS IN BIOTECHNOLOGY

Renewable methanol as fermentation feedstock: the paraformaldehyde gambit

Article

作者: Bemer, Ger G ; Visscher, Bram J ; Swinkels, Bart W ; van Roosmalen, Timo J P ; de Bont, Jan A M ; Wery, Jan

Renewable methanol is a promising feedstock for the bioproduction of single cell protein (SCP) and circular chemicals. Economic implementation is, however, burdensome due to the high oxygen demands inherently associated with methanol conversion. An alternative approach in circumventing this bottleneck via paraformaldehyde is proposed and discussed.

2025-11-01·Annals of Physical and Rehabilitation Medicine

Low back pain and disability trajectories in primary care: a growth mixture modeling analysis

Article

作者: Lemmers, Gijs P G ; Hak, Robin ; Melis, René J F ; Haaksma, Miriam L ; van der Wees, Philip J ; Staal, J Bart ; Pagen, Sophie ; Westert, Gert P

BACKGROUND:

People with low back pain are a heterogeneous group with diverse symptoms and recovery patterns, highlighting the need for a better understanding of trajectories toward either rapid resolution or chronicity with persistent disease burden.

OBJECTIVES:

The aim of this study is to identify clustering of pain and disability trajectories and predictors thereof in adults seeking physical therapy care for low back pain.

METHODS:

People (n=347) were followed for 12 months in a prospective cohort. Growth classes were identified using growth mixture modeling (GMM) separately for pain and disability. Pseudo-class method was used to calculate the odd ratios between the assigned growth class for pain and disability.

RESULTS:

The best-fitting GMM identified two growth classes in both the pain and disability courses. One trajectory with people with moderate pain/disability at first visit that recovered and a second trajectory with people with moderate pain/disability at first visit that did not recover. People in the worst class for disability had higher odds of being the worst class for pain as well (OR 6.8, 95% CI 1.69-9.28). Predictors of class membership for the worst classes in pain and disability were longer duration of complaints (OR 1.24, 95% CI 1.02-1.46) for pain and higher baseline NPRS score (OR 1.31, 95% CI 1.09-1.52) and higher baseline STarT Back Screening Tool (SBST) score (OR 5.49, 95% CI 1.69-9.28).

CONCLUSION:

The odds are high for people in the non-recovery class for disability to also be in the worst recovery class for pain. Longer duration of complaints, higher pain scores, and presence of more psychosocial factors were identified as predictors of slower recovery trajectories. People might benefit from tailored treatment based on these prognostic factors.

REGISTRATION:

Clinicaltrials.gov 109643; Ethics committee RadboudUMC 2020-6295.

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