Decontamination Plan for the Concrete of the Activated Accelerator Room and Its Implementation: A Case Study in the Decommissioning of the PET Cyclotron Room at the Medical and Pharmacological Research Center Foundation

作者: Masumoto, Kazuyoshi ; Matsumura, Hiroshi ; Miyazaki, Yoshiharu ; Yoshida, Go ; Tanaka, Masahiro

Herein, we present the case study of the decontamination of highly activated concrete in the accelerator room.The activated cyclotron room for pharmaceutical for the positron emission tomog. (PET) in the Medical and Pharmacol. Research Center Foundation (Ishikawa, Japan) was decontaminated.The contact dose rates of the concrete walls, floor, and ceiling were measured at 50 cm mesh using a NaI survey meter.The depth profiles of specific activity in the concretes were obtained by core boring at seven different places.The activated concrete regions were estimated in detail based on the relationship between the measured contact dose rates and depth profiles of the specific activity.The activated concrete was chipped and removed based on the estimated activated region.Then, through remeasurement, it was confirmed that the removal of the activated concrete was completed.The measurement of the contact dose rate using the NaI survey meter could determine the removal depths of the concrete at short range mesh.This contributed to the reduction of radioactive waste.

2018-03-01·American Journal of Neuroradiology2区 · 医学

Optimization of DARTEL Settings for the Detection of Alzheimer Disease

2区 · 医学

Article

作者: Matsuda, H ; Yamada, M ; Sakai, K ; Samuraki, M ; Komatsu, J ; Shima, K ; Matsunari, I ; Hamaguchi, T ; Ono, K ; Noguchi-Shinohara, M

BACKGROUND AND PURPOSEAlthough Diffeomorphic Anatomical Registration Through Exponentiated Lie Algebra (DARTEL) has been introduced as an alternative to conventional voxel-based morphometry, there are scant data available regarding the optimal image-processing settings. The aim of this study was to optimize image-processing and ROI settings for the diagnosis of Alzheimer disease using DARTEL.MATERIALS AND METHODSBetween May 2002 and August 2014, we selected 158 patients with Alzheimer disease and 198 age-matched healthy subjects; 158 healthy subjects served as the control group against the patients with Alzheimer disease, and the remaining 40 served as the healthy data base. Structural MR images were obtained in all the participants and were processed using DARTEL-based voxel-based morphometry with a variety of settings. These included modulated or nonmodulated, nonsmoothed or smoothed settings with a 4-, 8-, 12-, 16-, or 20-mm kernel size. A z score was calculated for each ROI, and univariate and multivariate logistic regression analyses were performed to determine the optimal ROI settings for each dataset. The optimal settings were defined as those demonstrating the highest χ² test statistics in the multivariate logistic regression analyses. Finally, using the optimal settings, we obtained receiver operating characteristic curves. The models were verified using 10-fold cross-validation.RESULTSThe optimal settings were obtained using the hippocampus and precuneus as ROIs without modulation and smoothing. The average area under the curve was 0.845 (95% confidence interval, 0.788-0.902).CONCLUSIONSWe recommend using the precuneus and hippocampus as ROIs without modulation and smoothing for DARTEL-based voxel-based morphometry as a tool for diagnosing Alzheimer disease.

2016-12-06·Journal of Alzheimer's Disease3区 · 医学

Cerebral Amyloid Angiopathy-Related Microbleeds and Cerebrospinal Fluid Biomarkers in Alzheimer’s Disease

3区 · 医学

Article

作者: Ono, Kenjiro ; Ikeda, Tokuhei ; Nakamura, Hiroyuki ; Matsunari, Ichiro ; Sakai, Kenji ; Hamaguchi, Tsuyoshi ; Yamada, Masahito ; Komatsu, Junji ; Samuraki, Miharu ; Noguchi-Shinohara, Moeko

BACKGROUNDAlzheimer's disease (AD) commonly accompanies cerebral amyloid angiopathy (CAA).OBJECTIVEWe aimed to reveal associations between CAA-related brain microbleeds and cerebrospinal fluid (CSF) markers in AD patients.METHODSPatients with probable AD (n = 88) from consecutive patients in our memory clinic were evaluated for patient demographics, vascular risk factors, neuropsychological tests, apolipoprotein E phenotype, MRI including T2*-weighted image and fluid attenuated inversion recovery sequence, and CSF amyloid and tau markers.RESULTSThe 88 patients with AD included 15 with microbleeds only in cortical/subcortical regions (cortical microbleeds) that could be CAA-related, 16 with microbleeds only in deep locations (deep microbleeds), 3 with microbleeds in both cortical and deep locations (mixed microbleeds), and 54 without microbleeds. The CSF levels of amyloid β-protein 1-40 (Aβ40) and amyloid β-protein 1-42 (Aβ42) were significantly lower in patients with cortical microbleeds than in those without microbleeds (p = 0.001 and p = 0.027, respectively). The result remained unchanged after adjustment for age, sex, apolipoprotein E E4 presence, and leukoaraiosis.CONCLUSIONSCAA-related cortical microbleeds would be associated with lower CSF levels of Aβ40 and Aβ42 in AD, reflecting the deposition of both Aβ40 and Aβ42 in the cerebrovasculature.

100 项与 The Medical & Pharmacological Research Center Foundation 相关的药物交易

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100 项与 The Medical & Pharmacological Research Center Foundation 相关的转化医学

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