更新于：2024-11-01

Hospital Civil de Guadalajara

Mexico

更新于：2024-11-01

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项与 Hospital Civil de Guadalajara 相关的临床试验

NCT06664762 / RecruitingN/AIIT

Left Lateral Position Versus Supine Position in Colonoscopy, a Multicenter Single-blind Randomized Clinical Trial Study

Currently, colonoscopy is a minimally invasive method that can be used as a diagnostic and therapeutic method by endoscopists, gastroenterologists and coloproctologists. Due to the importance and big impact this method has, it is necessary to both optimize its efficiency, and improve its quality, which is one of the main objectives of this protocol.
By observing which position it´s faster and which one also results in fewer complications when performing a colonoscopy without reducing its performance and following all the internationally established quality standards regarding colonoscoscopy.
The risk of this protocol implies a risk no greater than the minumum the procedure itself has, and does not generate extra cost for all of the patients subjected to this protocol.

开始日期2024-08-27

申办/合作机构

Hospital Civil de Guadalajara

[+1]

NCT06622512 / RecruitingN/AIIT

Double-Blind Randomized Controlled Trial Comparing the Effectiveness of Two Standardized Radial Pressure Wave Techniques Versus Pain-Site Guided Therapy in Patients With Knee Osteoarthritis.

The goal of this clinical trial is to evaluate and compare the effectiveness of radial pressure wave therapy (RPWT) applied at different anatomical sites in patients with knee osteoarthritis (OA) over a follow-up of four months. The main questions it aims to answer are:
How effective is the application of RPWT on the medial and lateral interarticular lines in patients with knee OA? Are standardized RPWT application techniques on interarticular lines superior to the traditional application technique on the points of greatest pain in patients with knee OA?
Researchers will compare the effectiveness of two standardized application techniques on interarticular lines to decrease pain and improve function in patients with knee OA.
Participants will receive three sessions of RPWT on the most painful knee as a result of knee OA.

开始日期2024-08-01

申办/合作机构

Hospital Civil de Guadalajara

[+1]

NCT06666556 / Recruiting临床4期IIT

Bowel Preparation in Colonoscopy: Lactulose Vs Polyethyleneglycol, Randomized Double-blind Comparative Clinical Trial, Multicenter Study.

The goal of this clinical trial it is to bowel the instestinal preparation with lactulose vs poliethylenglicol as better agent to have a quality colonoscopy and demostrate that lactulose is most efective, has a good tolerance and the patient would have a better satisfaction, so the question is:
wich is the eficancy of lactulose in comparision with thepoliethylenglycol in the intestinal preparation for the colonoscopy?

开始日期2024-07-20

申办/合作机构

Hospital Civil de Guadalajara

[+1]

100 项与 Hospital Civil de Guadalajara 相关的临床结果

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0 项与 Hospital Civil de Guadalajara 相关的专利（医药）

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247

项与 Hospital Civil de Guadalajara 相关的文献（医药）

2024-07-01·Multiple Sclerosis Journal - Experimental, Translational and Clinical

Early clinical effect of cladribine in patients with highly active multiple sclerosis in Mexico

Article

作者: De la Maza-Flores, Manuel ; Rodriguez-Leal, Francisco ; Quiñones, Sandra ; Gomez-Figueroa, Enrique ; Zuñiga-García, Gilberto ; Blaisdell-Vidal, Carlos ; Sauri-Suarez, Sergio ; Frias-Marquez, Francisco ; Bertado-Cortes, Brenda ; Playas-Pérez, Gil ; Marin-Contreras, Arturo

Background Cladribine shows efficacy in multiple sclerosis (MS), but Latin American (LATAM) real-world data is limited, despite potential sociodemographic variations. Objective Investigate baseline characteristics and clinical response in highly active MS patients in Mexico, identifying predictors of early treatment response. Method A multicenter cohort study analyzed retrospective data from individuals with “highly active” MS in the Cladribine Patient Support Program across 11 Mexican clinics. Criteria included one-year prior treatment with another disease-modifying treatment and recent relapse with specific MRI findings. Primary outcomes focused on achieving NEDA-3 status after 12 months. Results In the follow-up, 67.5% maintained NEDA-3 status. Baseline EDSS scores decreased significantly from 1.50 to 1.00 ( p = 0.011), with no confirmed disability worsening. No significant differences were observed between NEDA-3 achievers and non-achievers in demographic and clinical variables. No severe adverse events were reported. Conclusion Cladribine showed early and effective control of active MS in Mexican patients, demonstrating a secure profile with minimal adverse events. This study provides valuable real-world evidence in the LATAM context.

2024-06-18·Neuro-Oncology

LMIC-15. OUTCOMES OF PEDIATRIC MEDULLOBLASTOMA IN LOW- AND MIDDLE-INCOME COUNTRIES: A REPORT OF 330 PATIENTS FROM 8 COUNTRIES

作者: Baticulon, Ronny E ; Alcasabas, Ana Patricia A ; Pineda, Estuardo ; Sharafeldin, Hend A ; Casavilca-Zambrano, Sandro ; Foo, Jen Chun ; Zia, Nida ; Polanco, Ana ; Fadel, Shady ; Campo, Regina Navarro-Martin del ; Negreiros-Chinchihuara, Tatiana ; Arredondo-Navarro, Luis ; Qaddoumi, Ibrahim ; Hamid, Ahmer ; Omran, Nuha ; Ganesan, Dharmendra ; Seddik, Khaled ; Escamilla, Gabriela ; Campos, Danny A ; Hernandez-Broncano, Eddy ; Devidas, Meenakshi ; García, Beatriz ; Rajagopal, Revathi ; Syed, Yumna ; Moreira, Daniel C ; Amarillo, Paloma ; Faughnan, Lane ; Yousuf, Bisma ; Job, Godwin ; Villegas, Cesar A ; Diaz-Coronado, Rosdali ; Khu, Kathleen ; Ruvalcaba, Rafael

AbstractBACKGROUND AND AIMSReports from low-and middle-income countries (LMICs) indicate lower survival in medulloblastoma (MB), though these studies are mainly from single institutions. This multi-institutional, retrospective study aimed to analyze the outcomes for MB in 9 centers in 8 LMICs.METHODSPatients <18 years old with newly diagnosed MB, treated from January 2014 to December 2018 in Egypt, El Salvador, Malaysia, Mexico, Pakistan, Peru, Philippines, and Uruguay were included. Data on demographics, clinical presentation, treatment and biological characteristics were collected. Factors associated with patient outcomes were analyzed.RESULTSThe study included 330 patients with a median age of 7.7 years. Of these, 49 patients (15%) were <3 years old and 212 (64%) were male. Eighty-eight patients (26%) had experienced symptoms for >3 months at diagnosis. Gross total resection was achieved in 153 (47%) patients. Sixty-three patients (19%) experienced post-operative infections. Eighty-four patients (24%) had metastatic disease at diagnosis. The histologic subtype was not specified in 98 cases (30%), and 25 patients (7%) had molecular subgroups identified. Radiotherapy was administered to 216 patients (64%). The median number of chemotherapy cycles was 8 (range 0-14). There were 64 patients (19%) who abandoned treatment, and 24 patients (7%) died due to treatment-related toxicity. The 5-year event-free survival (EFS) was 44±4%, while the 5-year overall survival was 58±4%. The 5-year EFS for patients <3 years was 42±9%, while 44±4% for older patients (p=0.49). The 5-year EFS for patients with metastasis was 38±7%, while it was 46±4% for patients without metastasis (p=0.13).CONCLUSIONSThis large, multinational cohort of MB in LMICs describes poor outcomes, which may be attributed to delays in care, high abandonment rate, surgical complications, treatment-related mortality and a low fraction of patients receiving radiotherapy. Interventions to build care capacity can be prioritized based on these data.

2024-06-18·Neuro-Oncology

GCT-02. OPTIC PATHWAY PRIMARY GERMINOMA: DON´T MISS THE DIAGNOSIS

作者: Huerta-Hurtado, Alma M ; Orozco-Alvarado, Ana L ; Saldaña-Alcalá, David ; Campo, Regina M Navarro-Martin del

AbstractBACKGROUNDGerm Cell tumors usually arise in the midline of brain; location in optic pathway (OP) is extremely rare. This case illustrates an OP primary Germinoma.METHODSA 9 years old female debuted with diminished visual acuity, it was diagnosed and treated as optic neuritis without improvement, a MRI evidenced a gadolinium enhancement with a very subtle thickening on the optic chiasm, along 3 non conclusive vascular like images in the left Virchow space. A differential diagnosis between endophytic Optic pathway glioma and germ cell tumor was made.RESULTSAssessment of AFP and Sub HCG in both blood and CFS was negative, endocrine evaluation confirmed Diabetes insipidus. A stereotaxic biopsy was performed and Pathology confirmed a Pure Germinoma. Non metastatic disease was confirmed as negative Spine MRI and acellular CFS. As a relevant familiar History the father had testicular Germinoma in his teenage. She was treated with 9 weeks of Carboplatin/V16 and radiotherapy as follows: whole ventricular 24 Gy and primary site 16.5 Gy for a total dose of 40.05 Gy. She is free of tumor at 3 follow up years with improvement in visual acuity and arginine vasopressin dependence.CONCLUSIONSThis case illustrates a germ cell tumor primary arising in the optic pathway and aware us to consider it as a differential diagnosis with non-exophytic optic pathway Glioma being the biopsy mandatory to establish the correct diagnosis

100 项与 Hospital Civil de Guadalajara 相关的药物交易

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100 项与 Hospital Civil de Guadalajara 相关的转化医学

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