Delving into the Latest Updates on University of Amity with Synapse

概览

疾病领域	数量

肿瘤	4

排名前五的药物类型	数量

小分子化药	4

排名前五的靶点	数量

CDK1(细胞周期蛋白依赖性激酶1)	1

关联

4

项与 University of Amity 相关的药物

Carbazole derivative

靶点

CDK1

作用机制

CDK1抑制剂

在研机构

University of Amity [+1]

原研机构-

在研适应症

乳腺癌 [+1]

非在研适应症-

最高研发阶段临床前

首次获批国家/地区-

首次获批日期-

CNP0243075

靶点-

作用机制-

在研机构

University of Amity

原研机构

University of Amity

在研适应症

肿瘤

非在研适应症-

最高研发阶段药物发现

首次获批国家/地区-

首次获批日期-

CNP0211397

靶点-

作用机制-

在研机构

University of Amity

原研机构

University of Amity

在研适应症

肿瘤

非在研适应症-

最高研发阶段药物发现

首次获批国家/地区-

首次获批日期-

100 项与 University of Amity 相关的临床结果

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0 项与 University of Amity 相关的专利（医药）

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13,995

项与 University of Amity 相关的文献（医药）

2025-04-01·Systems Microbiology and Biomanufacturing

Polycyclic aromatic hydrocarbons degradation by free-air CO2 enriched (FACE) bacteria into low molecular easy to degrade organic compounds

作者: Sharma, Arti ; Maheshwari, Neha ; Thakur, Indu Shekhar ; Srivastava, Shaili ; Manyapu, Vivek

Among the 16 prioritized polycyclic aromatic hydrocarbons (PAHs), naphthalene, phenanthrene, fluoranthene, and pyrene have been used for bacterial degradation study.From the free-air CO₂ enriched (FACE) soil, five Bacillus strains were isolated and used to utilize the four model toxicants at different concentrations as the sole carbon source.Bacillus amyloliquefaciens has great resistance to different PAHs and better degradation capability.B. amyloliquefaciens can degrade naphthalene (0.5 mg mL^- 1), fluoranthene (0.1 mg mL^- ¹), and pyrene (0.1 mg mL^- ¹) up to 94%, 65%, and 56% resp., while B. cereus mineralized phenanthrene (0.5 mg mL^- ¹) up to 71% within seven days of incubation.B amyloliquefaciens and B. cereus have the capability of ring cleavage and they can convert PAH compounds into less toxic compoundsBased on the metabolites obtained through GC-MS, the biodegradation pathways for each PAH have been predicted to end up in the tricarboxylic acid cycle.

2025-03-01·Biomass Conversion and Biorefinery

An investigation of fatigue, creep, and dynamic mechanical behavior of bio-fiber-reinforced PLA and their hybrid biocomposites

作者: Dwivedi, Shashi Prakash ; Gupta, Pallav ; Chaudhary, Vijay ; Sharma, Bhasha ; Das, Partha Pratim

Abstract: In the present research work, three combinations of composite samples, jute and nettle fibers reinforced with polylactic acid (PLA) composites, and their hybrids (jute/PLA, Nettle/PLA, and jute/nettle/PLA) were fabricated using compression molding process.Present work aimed at the exptl. investigation of fatigue, creep, dynamic mech. behavior (DMA), and X-ray diffraction (XRD) of all fabricated composite specimens.Hybridization of jute and nettle fiber enhanced the fatigue cycles and creep strain rate of the developed jute/nettle/PLA hybrid composite as compared to neat PLA and other composite specimens.Exptl. results of DMA focused that it is observed by the damping factor (tan δ); all composite specimens obtained higher value of glass transition temperature as compared to neat PLA.Jute/PLA and nettle/PLA composites achieved the maximum glass transition temperature of 64 °C at a damping factor of 1.Jute/nettle/PLA hybrid composites obtained the uppermost value (4775.9 MPa) of storage modulus which is more than four times of neat PLA at room temperatureJute/nettle/PLA hybrid composite obtained the highest loss modulus 550.36 MPa.In XRD, jute and nettle fibers showed small peaks at diffraction angles of 17 to 30° which indicated the presence of various constituents such as cellulose, lignin, and pectin present in these natural fibers.

2025-03-01·Biomass Conversion and Biorefinery

Studies on water uptake behavior and mechanical performance of bio-wastage-reinforced bio composites for improved sustainability

作者: Dhyani, Vedik ; Gupta, Pallav ; Radhakrishnan, Sidharth ; Chaudhary, Vijay ; Dwivedi, Shashi Prakash ; Sadhu, Susmita Dey ; Mishra, Ranjana

Abstract: In the present study, the effect of moisture absorption on the properties of jute/flax-reinforced epoxy composite with coconut shell powder and eggshell powder as nanofillers was investigated.The nanocomposite samples were immersed in water for 6 mo then they were tested for various mech. properties in accordance with ASTM or ISO standardsSEM (SEM) was used to identify the potential cause of failure of the specimen after mech. tests.From the experimentations, it was found that jute/epoxy/coconuts shell powder, jute/epoxy/eggshell, flax/epoxy/coconut shell, and flax/epoxy/eggshell showed a reduction in their tensile strength of 29.29%, 24.89%, 20.17%, and 21.56% resp.They also showed reduced flexural strength of 19.72%, 18.46%, 22.63%, and 19.06% resp.Similarly, jute/epoxy/coconuts shell powder, jute/epoxy/eggshell, flax/epoxy/coconut shell, and flax/epoxy/eggshell showed a reduction in their impact strength of 11.35%, 6.88%, 9.25%, and 8.57% resp.But water immersion showed a pos. result on the surface roughness of the nanocomposite as the surface roughness of jute/epoxy/coconut shell and jute/epoxy/eggshell slightly improved by 12.5% and 14.28% resp.Morphol. anal. using SEM demonstrated fiber pullout, debonding, and voids due to moisture uptake which are responsible for weak interfacial adhesion between fiber and matrix which affects the overall performance of developed nanocomposites.

100 项与 University of Amity 相关的药物交易

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100 项与 University of Amity 相关的转化医学

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2025年08月28日管线快照

管线布局中药物为当前组织机构及其子机构作为药物机构进行统计，早期临床1期并入临床1期，临床1/2期并入临床2期，临床2/3期并入临床3期

药物发现

3

1

临床前

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当前项目

药物(靶点)	适应症	全球最高研发状态

Carbazole derivative ( CDK1 )	结直肠癌更多	临床前
CNP0003920	肿瘤更多	药物发现
CNP0211397	肿瘤更多	药物发现
CNP0243075	肿瘤更多	药物发现