Babol University of Medical Sciences (Babol University of Medical Sciences)

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396

项与 Babol University of Medical Sciences 相关的临床试验

IRCT20240730062588N1 / SuspendedN/AIIT

Assessing the impact of pulmonary rehabilitation through meditation training on respiratory status and depression in patients with chronic obstructive pulmonary disease.

开始日期2024-10-21

申办/合作机构

Babol University of Medical Sciences

IRCT20221109056451N3 / Recruiting临床3期IIT

Assessing the effectiveness of a fertility education program on the motivation of childbearing among girls attending premarital counseling centers: a randomized controlled trial

开始日期2024-10-11

申办/合作机构

Babol University of Medical Sciences

IRCT20240923063126N1 / Recruiting临床3期IIT

Comparison of the hemodynamic complications (Blood Pressure and Heart Rate) of propofol and Fentanyl with thiopental sodium and Fentanyl administration in intrathecal chemotherapy of children aged2 to 15 years with Acute lymphoblastic leukemia: a randomized clinical trial

开始日期2024-10-06

申办/合作机构

Babol University of Medical Sciences

100 项与 Babol University of Medical Sciences 相关的临床结果

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0 项与 Babol University of Medical Sciences 相关的专利（医药）

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6,121

项与 Babol University of Medical Sciences 相关的文献（医药）

2025-02-01·Protein Expression and Purification

Anti-biofilm and antibacterial effect of bacteriocin derived from Lactobacillus plantarum on the multidrug-resistant Acinetobacter baumannii

Article

作者: Javadi, Kasra ; Halaji, Mehrdad ; Parsian, Hadi ; Pournajaf, Abazar ; Emadzadeh, Mohammad Reza ; Mohammadzadeh Hosseini Moghri, Seyed Amir Hossein ; Rajabnia, Mehdi

This research examines the impact of bacteriocin derived from Lactobacillus plantarum PTCC 1745 on the biofilm formations of A. baumannii isolates. Bacteriocin derived from L. plantarum PTCC 1745 was obtained through ammonium sulfate precipitation, cation-exchange chromatography, and reversed-phase high-performance liquid chromatography (RP-HPLC). Testing for bacteriocin susceptibility has been conducted using the broth dilution method. The anti-biofilm activity of bacteriocin was evaluated using a microtiter plate method. Quantitative real-time PCR assay evaluated bap gene expression in bacteriocin-treated cells. According to SDS-PAGE, bacteriocin from L. plantarum has a 25-kDa apparent molecular weight. The MICs of bacteriocin ranged from 30 to 120 μg/mL, while the MBCs varied between 60 and 120 μg/mL. Compared to the non-treated group, strains bacteriocin-treated isolates had 59 % less ability to form biofilm. The mean relative expression of the bap gene among the MDR A. baumannii isolates decreased by 52 % compared to the untreated control. This study demonstrated that bacteriocin derived from L. plantarum PTCC 1745 had antibacterial and antibiofilm activity against MDR A. baumannii isolates.

2025-01-01·Clinica Chimica Acta

miRNA-based electrochemical biosensors for ovarian cancer

Review

作者: Khatami, Seyyed Hossein ; Vahedi, Farzaneh ; Ghasemi, Hassan ; Fattahi, Mehdi ; Rouhi, Saber ; Movahedpour, Ahmad ; Aiiashi, Saleh ; Alizadeh, Mehdi

Ovarian cancer, a prevalent and deadly cancer among women, presents a significant challenge for early detection due to its heterogeneous nature. MicroRNAs, short non-coding regulatory RNA fragments, play a role in various cellular processes. Aberrant expression of these microRNAs has been observed in the carcinogenesis-related processes of many cancer types. Numerous studies highlight the critical role of microRNAs in the initiation and progression of ovarian cancer. Given their clinical importance and predictive value, there has been considerable interest in developing simple, prompt, and sensitive miRNA biosensor strategies. Among these, electrochemical sensors have demonstrated advantageous characteristics such as simplicity, sensitivity, low cost, and scalability. These microRNA-based electrochemical biosensors are valuable tools for early detection and point-of-care applications. This article discusses the potential role of microRNAs in ovarian cancer and recent advances in the development of electrochemical biosensors for miRNA detection in ovarian cancer samples.

2024-12-31·International Journal of Adolescence and Youth

The spiritual health of parents and their role in preventing children’s addiction using the theory of planned behavior