Oncomyx Therapeutics, Inc.

The last year has demonstrated that a sound financing strategy and compelling company narrative are essential to securing funding – it’s become more important than ever that investors are excited before taking the plunge. Given the current economic environment that is causing challenges in biopharma, how should companies be approaching funding in 2024? Listen to this discussion on different kinds of funding options available, how companies can optimize their chances to secure funding and how they should be assessing VCs in addition to alternative partners – particularly if your company will be seeking funding at JPM this January. Our host and guests also discuss current challenges, how to weather adversity, and what investment trends are anticipated for next year. This roundtable discussion occurs Thursday, January 4. Subscribe below to receive an update with a link to the video the morning it goes live. By submitting your email address, you agree to receive communications from BioSpace. PANELISTS Jeff Burton | Halia Therapeutics | CFO Jeff Burton joined Halia Therapeutics as the Chief Financial Officer in December 2020. ‌Prior to coming to Halia, Jeff was with Tolero Pharmaceuticals where he helped guide the company through several rounds of funding, the acquisition of Tolero by Sumitomo Dainippon Pharma for $200 million upfront and $500 million in milestones, and provided support for the successful filing of five INDs and completion of nine clinical trials. ‌Prior to Tolero, Jeff was at Fusion-io, where he helped the company successfully complete its IPO, secondary offering, several acquisitions, key system implementations, and the eventual acquisition of Fusion-io by SanDisk for more than $1.1 billion. ‌Jeff holds Bachelor and Master of Accounting degrees from the University of Utah. Karen Harris | The Alzheimer’s Drug Discovery Foundation | CFO and Head of Mission-Related Investing Karen Harris is a member of the Alzheimer’s Drug Discovery Foundation’s executive team and serves as its Chief Financial Officer and Head of Mission Related Investments. ‌With a CFO background that spans both non-profits and investment banking, Ms. Harris is committed to increasing transparency and accessibility of complex financial information and heightening organizational effectiveness with robust financial governance, strategic planning, policies, controls, and training. She regularly presents to the ADDF’s Boards of Governors and Overseers, launched a board-level Finance and Audit Committee, and oversees the organization’s banking relationships. As Head of Mission Related Investments, Ms. Harris has also structured and stewarded dozens of venture-based investments for the ADDF, and she manages and monitors its extensive portfolio of securities and royalty arrangements with universities and biotech companies. ‌Previously, Ms. Harris served as Chief Financial Officer for the East Harlem Tutorial Program and Director of Development at Mount Sinai Adolescent Health Center. She also led a career in the financial sector for 20+ years prior to her transition to non-profit leadership. Among other roles, Ms. Harris served as Global COO for global equity capital markets, a $1 billion dollar division with 190 bankers at UBS, and as a Director and investment banker at Merrill Lynch. She earned an MBA in Finance from Stanford Graduate School of Business, graduating first in her class, and a BA in Economics from Columbia University. Rob Williamson | Triumvira Immunologics | President and COO Robert F. Williamson, III has been active in building biotechnology companies and shareholder value for over two decades. He currently is the President and COO of Triumvira Immunologics. Previously, he was the CBO of OncoMyx, an oncolytic virus company, and CEO of BioTheryX, a protein degradation therapeutics company, raising a $100M crossover round and preparing the company for an IPO. Prior to BioTheryX, Mr. Williamson served as CEO of both PharmAkea and ATXCo, oncology and fibrosis companies financed through a partnership with Celgene, until PharmAkea’s acquisition by Galecto and ATXCo’s acquisition by Blade Therapeutics. Prior, Mr. Williamson was CEO of Arriva Pharmaceuticals, President and COO of Eos Biotechnology, which he sold to Protein Design Labs, and COO of DoubleTwist, Inc. through its acquisition by Merck and Hitachi. ‌Mr. Williamson also serves as a director and adviser for foundations, private, and public companies. Notably, Mr. Williamson served as an early Director of Pharmasset, Inc., where he helped finance, grow, and advance the company into the public markets and through its acquisition by Gilead in 2011 for $11 billion. Earlier, Mr. Williamson was a partner with The Boston Consulting Group and a research assistant for the Federal Reserve Board. He received a BA in economics from Pomona College and an MBA from Stanford. HOST ⁠⁠⁠⁠Lori Ellis⁠⁠⁠ | BioSpace | Head of Insights Lori is the head of insights at BioSpace. She analyzes and comments on industry trends for BioSpace and clients. She creates engaging content for clients to support their marketing objectives. She has been part of an award-winning marketing team and has won a Muse Creative award, a Vega award and several Adobe awards in collaborative team projects for her audio narration work. Her experience in the television/film and audio industries benefits both BioSpace and partners through her moderation and hosting of live and virtual events. While she has covered all elements of the drug development process, her current focus is on the ever-evolving impact of technology – specifically artificial intelligence – on the pharmaceutical industry.⁠

Judith Oke The biopharma company has filed a comprehensive patent to address cystic fibrosis and other ailments. Image Credit: Zerbor/Shutterstock Porosome Therapeutics has announced a potentially novel treatment for cystic fibrosis while stating that it has filed a comprehensive patent for the new therapy in cystic fibrosis and other diseases. The biopharma refers to the new therapy aimed at treating cystic fibrosis (CF) as the first application of the porosome, which is the secretory portal in cells . Porosomes are lipoproteins at the cell plasma membrane that promote cellular communication by secreting chemical messages, which are important to sustain life. The secretory defects in the porosome are implicated in diseases such as neurological disorders, immune disorders, various cancers, diabetes, and CF. Recommended Reports Reports LOA and PTSR Model - Vaccine To Target Brachyury For Oncology in Metastatic Hepatocellular Carcin... GlobalData Reports LOA and PTSR Model - Cellular Immunotherapy To Target Cd3 And Her2 For Oncology in Leptomeningeal... GlobalData View all Companies Intelligence Vertex Corp Porosome Therapeutics Inc Viron Corporation View all CF is a genetic disorder that causes chronic lung infections due to the mucus build-up that is thick and sticky and progressive lung damage that could potentially be deadly. It occurs from missing cystic fibrosis transmembrane conductance regulatory (CFTR) proteins caused by mutations in the CFTR gene. The company announced on 6 August that it was no longer Viron but Porosome Therapeutics to reflect its fundamental research centred on the porosome complex. Founder and Chairman of Porosome Therapeutics, Professor Bhanu P. Jena said: “By incorporating normally functioning CFTR-associated porosomes into diseased cells or by specifically targeting affected porosome proteins, these proposed therapies will ameliorate cystic fibrosis symptoms at a fundamental level, restoring function and thereby treating the disorder.” Guillermo Marmol CEO Porosome Therapeutics said: “While treatments exist to lessen symptoms and consequences of cystic fibrosis, until Porosome Therapeutics’ ground-breaking development, none of the existing treatments have addressed the CFTR-mutated protein in terms of its secretory ecosystem.” “As the discoverer of the porosome and its potential, and following decades of research, Porosome Therapeutics’ founder has inspired its incredible team to unleash the body’s existing yet untapped capabilities of self-generation to effectively address the core cause of cystic fibrosis symptoms.” Unlike Vertex’s Orkambi (lumacaftor/ivacaftor) and Trikafta (elexacaftor, ivacaftor and tezacaftor), Porosome Therapeutics uses two treatment pathways for CF. One is the use of non-invasive methods to insert a healthy porosome into a diseased cell, replacing the mutated protein and restoring mucin secretion and function in organs. Another pathway is introducing small molecules to restore secretory function to implicated porosome proteins. Porosome Therapeutics notes that its studies on human lung epithelial cell lines expressing cystic fibrosis have shown significant – and unprecedented – enhancement of mucin secretion. Our signals coverage is powered by GlobalData’s Thematic Engine , which tags millions of data items across six alternative datasets — patents, jobs, deals, company filings, social media mentions and news — to themes, sectors and companies. These signals enhance our predictive capabilities, helping us to identify the most disruptive threats across each of the sectors we cover and the companies best placed to succeed.

PITTSBURGH, May 10, 2023 /PRNewswire/ -- KaliVir Immunotherapeutics, Inc., a biotech company developing cutting-edge, multi-mechanistic oncolytic viral immunotherapy programs, today announced the appointment of Grant McFadden, Ph.D., to its Board of Directors. McFadden joins the Board as an independent director. McFadden is the director of the Biodesign Center for Immunotherapy, Vaccines and Virotherapy and a Professor at Arizona State University. McFadden's lab pioneered the field of viral immune subversion (also called "anti-immunology") and is credited with the discovery of a wide spectrum of virus-derived inhibitors of the immune system. He was co-founder and Board member of OncoMyx Therapeutics and has served on advisory boards for numerous companies including Jennerex, DNAtrix and IMV. A recognized international expert, McFadden is a former President of the American Society of Virology, a member of the International Committee on the Taxonomy of Viruses, advisor to the World Health Organization Advisory Committee on Variola Virus Research, and a fellow of the Royal Society of Canada, the Canadian Academy of Health Sciences, and the American Academy of Microbiology. He received a Ph.D. in Biochemistry from McGill University. "KaliVir has exciting technology and a stellar team and I am honored to join its Board of Directors as the company progresses its first candidate into the clinic," said McFadden. "KaliVir's approach to immunotherapy combines the natural ability of certain viruses to kill cancer cells with novel mechanisms to stimulate anti-tumor immunity, notably, with the ability to do so intravenously. This is a critical advantage and I look forward to being part of the team to advance this important science." "With extensive knowledge about viral immunology, Dr. McFadden is a highly respected leader in the field and the ideal addition to our Board of Directors at this exciting stage of growth," said Helena Chaye, PhD, JD, Chief Executive Officer of KaliVir. "His counsel and expertise will be invaluable as we advance our lead candidate, VET3-TGI, toward the clinic and continue to collaborate with our partners." About KaliVir Immunotherapeutics, Inc. KaliVir Immunotherapeutics is a privately held biotech company developing cutting-edge, multi-mechanistic oncolytic viral immunotherapy programs. The company has developed a unique vaccinia virus-based platform, Vaccinia Enhanced Template "VET" Platform, that can generate potent novel oncolytic vaccinia viruses with modifications to maximize viral replication and to enhance intravenous delivery and spread. VET™ platform utilizes the large transgene capacity of the vaccinia virus to deliver therapeutics matched to tumor immunophenotypes to stimulate patients' immune systems and modify the tumor microenvironment. KaliVir's oncolytic virus candidates are designed to be safe, potent and systemically deliverable to treat cancer patients across multiple tumor types. KaliVir has separate collaborations with Roche and Astellas Pharma to design and generate novel oncolytic vaccinia viruses derived from the VET™ platform. In addition, Astellas entered into a world-wide exclusive license to develop and commercialize KaliVir's initial lead clinical candidate VET2-L2 oncolytic vaccinia virus. KaliVir is currently advancing multiple therapeutic candidates toward the clinic. For more information, please visit . Media Contact: Michael Falcone MacDougall Advisors [email protected] 781-591-3448 SOURCE KaliVir Immunotherapeutics