The Relationship Between Serum Beta-2 Microglobulin (sB2M) Levels and CD8+ Cell Infiltration in Hodgkin Lymphoma Tissues: Impact on Chemotherapy Outcomes

In newly diagnosed Hodgkin lymphoma patients, pre-treatment Beta-2 Microglobulin (B2M) levels will be measured. A thorough baseline assessment will be performed using CT imaging, and tumor tissue samples will be collected for Immunohistochemical (IHC) analysis to quantify CD8+ cell infiltration. Patients will be closely monitored throughout their treatment, with a follow-up CT scan at the end of therapy to evaluate therapeutic response. This study aims to investigate the correlation between pre-treatment B2M levels and CD8+ immune cell infiltration in tumor tissues, assessing their potential as predictive markers for chemotherapy response.

开始日期2024-01-04

申办/合作机构

Tishreen University

NCT05816096

/ RecruitingN/AIIT

Atraumatic Restoration Treatment Compared to the Hall Technique for Management Hypomineralization Second Primary Molars

Aims: Evaluation of treatment success on HSPM-affected molars after ART and Hall technique.
comparison of pain during treatment with ART and Hall technique in HSPM. comparison of child and parent satisfaction with restorations used by ART and Hall technique.
Design: A randomized, controlled, crossover clinical study including thirty children.

开始日期2023-03-26

申办/合作机构

Tishreen University

NCT06786598

/ CompletedN/AIIT

The Effect of Body Mass Index and Total Cholesterol Levels on Histopathological Grading in Breast Cancer Patients

Breast cancer is a widespread cancer that affects high percentiles of women worldwide.The development and aggressiveness of breast cancer cells can be evaluated depending on the histopathological grading which reflects the degree of differentiation. Several factors related to lifestyle can impact the development of breast cancer. Obesity is an important factor that received the attention in recent years. The using of body mass index(BMI) is still the common method for identifying obesity which is defined when having 30kg/m² or more. Previous epidemiological and clinical studies found that obesity was correlated with advanced breast cancer especially in postmenopausal patients . Also, the changes in cholesterol levels can influence breast cancer risk in the context of obesity. The findings of other studies is still controversial; many studies revealed that elevated total cholesterol levels could increase breast cancer risk while others found to have no effect. Due to the possibility of previous factors' effect on breast cancer progression, we purposed in this study to assess the association of BMI and total cholesterol with histopathological grading according to menopausal status among a group of breast cancer patients in Syria

开始日期2023-01-01

申办/合作机构

Tishreen University

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2025-12-31·Annals of Medicine

Exploring parents’ knowledge, attitudes and practices on honey and botulism in the West Bank, Palestine: a cross-sectional study

Article

作者: Warasna, Haya Jebreen Mohammed ; Awad, Mohammad Yaser Hasan ; Shahin, Farah Bilal Yousef ; Awad, Bashar Yaser Hasan ; Jobran, Afnan W. M. ; Mahfoud, Amal ; Owais, Tarek A.

BACKGROUNDAlthough nutritionally beneficial, honey may harbor Clostridium botulinum spores, posing risks to infant botulism (IB). Infants under one year are vulnerable due to immature gut flora, with IB potentially causing severe symptoms, such as respiratory failure. Despite global awareness, cultural beliefs influenced caregivers' practices in Palestine. This study evaluated Palestinian parents' knowledge, beliefs, and feeding practices regarding honey to guide targeted interventions.METHODSThis cross-sectional study (August-September 2024) surveyed 469 Palestinian parents (aged ≥18 years) from 10 West Bank cities, excluding 88 ineligible responses. A validated questionnaire assessed their knowledge, attitudes, and practices. Data were analyzed using the R software (frequency, Chi-squared/Fisher's tests; p < 0.05).RESULTSMost participants were female (89%), under 30 years old (53%), and highly educated (77%). While 58% knew of honey-linked IB, only 32% identified C. botulinum as the causative agent. Notably, 15.8% fed honey to infants aged <12 months and 62.5% introduced complementary feeding at 6-12 months. Age and income-influenced practices, with many believing that honey aids digestion or supplements nutrition.CONCLUSIONSThe findings reveal gaps in knowledge and widespread cultural beliefs about the benefits of honey, which contribute to unsafe feeding practices. Health interventions in Palestine should incorporate these insights to improve awareness and to prevent IB.

2025-08-01·Fuel

Structure of high-molecular components and their influence on the properties of oils from Syrian fields

作者: Ivanova, Lyudmila V. ; Vakhin, Alexey V. ; Djouadi, Younes ; Koshelev, Vladimir N. ; Khelkhal, Mohammed A. ; Mansour, G. ; Miller, Veronika. K. ; Chemam, Mohamed-Said ; Rodionov, Aleksandr A.

This study investigated the physico-chem. properties and component composition of four crude oils from Syrian oilfields.High-performance liquid chromatog. (HPLC), gas-liquid chromatog. (GLC), Fourier transform IR (FTIR) spectroscopy, ¹³C and ¹H NMR (NMR) spectroscopy, ESR (EPR) spectroscopy, and matrix-assisted laser desorption/ionization (MALDI) mass spectrometry was used to identify structural-group composition of oils and mol. characteristics of extracted asphaltenes and resins.Results demonstrated an increase in aromaticity coefficient and a decrease in aliphaticity coefficient in the sequence: oil → resins → asphaltenes.Bituminous oil, containing the highest total content of resins and asphaltenes (>25.0 %) and predominant bicyclic aromatic structures (17.7 %), demonstrated a high tendency for structure formation and low aggregative stability, primarily due to asphaltene precipitationRheol. studies revealed significant viscosity increases at +10 °C in oil with high resin asphaltene content due to asphaltene aggregation.At -10 °C, structure formation occurred through solid paraffin crystallization, with paraffinic oil showing the highest energy of oil dispersed system structure destruction (ODS).The study demonstrates the influence of high-mol. oil compounds′ structural-group composition on structure formation in the oil system.

2025-05-01·International Journal of Surgery Case Reports

Bilateral mandibular osteomyelitis following chemo-radiotherapy: Critical rare case report and review of literature

Article

作者: Bisher, Oday ; Khalil, Ali

INTRODUCTION AND IMPORTANCEOsteomyelitis, an inflammatory condition of the bone, poses significant challenges in clinical management due to its multifactorial etiology and variable presentation. Understanding the underlying mechanisms, risk factors, and biological processes is essential for improving treatment outcomes. Through this paper, we present an exceptionally rare case of "bilateral" aggressive osteomyelitis affecting the mandible, resulting in significant bone loss on both sides. Additionally, we review the literature to explore the causes of this disease and the factors contributing to its occurrence, aiming to understand its pathogenesis and improve prevention and treatment methods.CASE PRESENTATIONA 58-year-old male presented to our oral and maxillofacial department with a chief complaint of intense pain on both sides of the mandible, persisting for over 12 days. According to the patient, several months ago, the pain varied from mild to moderate, but recently it has increased dramatically. His medical history revealed enlarged lymphatic nodes on both sides of the neck. Consequently, the patient underwent a surgical procedure under general anesthesia to remove the enlarged nodes, followed by chemotherapy, and then 24 sessions of radiotherapy. After a while, the patient began to experience pain of varying intensity, and ulcers appeared, which increased in size over time.DISCUSSIONAfter confirming the diagnosis of osteomyelitis, we identified the radiation and chemotherapy to which the patient was exposed as the primary reason for the worsening of the condition. in addition, the injury to both sides of the mandible indicates two possibilities: the first is that the patient has a predisposition to develop osteomyelitis (due to genetic factors, possible ischemia, etc.), and the second is that radiological doses he received was excessive, combined with the immunodeficiency resulting from chemotherapy, contributed to the condition.CONCLUSIONResearch on jaw osteomyelitis highlights a complex interplay of factors that contribute to the development of this condition. Overall, effective prevention and management strategies should address these diverse causes.

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