Delving into the Latest Updates on Creative Biomolecules with Synapse

概览

疾病领域	数量

内分泌与代谢疾病	1
感染	1
肿瘤	1

排名前五的药物类型	数量

小分子化药	1

关联

1

项与 Creative Biomolecules 相关的药物

CLR01

靶点-

作用机制-

在研机构

Creative Biomolecules [+6]

原研机构

University of Duisburg-Essen

在研适应症

结核 [+5]

非在研适应症-

最高研发阶段临床前

首次获批国家/地区-

首次获批日期-

100 项与 Creative Biomolecules 相关的临床结果

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0 项与 Creative Biomolecules 相关的专利（医药）

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2

项与 Creative Biomolecules 相关的文献（医药）

1997-08-01·The Journal of Bone & Joint Surgery2区 · 医学

Stimulation of Proteoglycan Synthesis in Explants of Porcine Articular Cartilage by Recombinant Osteogenic Protein-1 (Bone Morphogenetic Protein-7)*

2区 · 医学

Article

作者: Masaki Yanagishita ; A. Hari Reddi ; T. K. Sampath ; Steven A. Lietman

Osteogenic protein-1 (also known as bone morphogenetic protein-7) is a member of the bone morphogenetic protein family. Bone morphogenetic proteins and related members of the TGF-beta (transforming growth factor-beta) superfamily are involved in the development and repair of bone. Recombinant bone morphogenetic proteins induce the formation of new cartilage and bone at heterotopic sites. We investigated the influence of recombinant osteogenic protein-1 (at doses of three, ten, thirty, or 100 nanograms per milliliter) on the synthesis and release of proteoglycans and the maintenance of a steady-state concentration of proteoglycans in explants of porcine articular cartilage that were maintained in chemically defined serum-free medium. We found a dose-dependent stimulation of proteoglycan synthesis and a concurrent decrease in the rate of release of proteoglycans from the explants. The size of the proteoglycan monomers and the composition of the glycosaminoglycan chains in the untreated articular cartilage were similar to those in the articular cartilage treated with osteogenic protein-1. The capacity of the newly synthesized proteoglycan monomers to form aggregates with exogenous hyaluronic acid was found to be similar to that of proteoglycans in bovine nasal cartilage. Our results demonstrated that osteogenic protein-1 stimulated the synthesis of proteoglycans and diminished the release of proteoglycans from explants of porcine articular cartilage.CLINICAL RELEVANCEThe maintenance and repair of articular cartilage is a formidable challenge in clinical orthopaedics. The stimulation of proteoglycan synthesis by osteogenic protein-1 (bone morphogenetic protein-7) in explants of cartilage maintained in chemically defined serum-free medium implies that recombinant osteogenic protein-1 may play a role in the maintenance of a steady-state concentration of proteoglycans in articular cartilage, a desirable prerequisite for optimum repair of cartilage. Osteogenic protein-1 can initiate the formation of cartilage from mesenchymal cells. Once new cartilage has formed at the site of repair, osteogenic protein-1 also may maintain the synthesis of proteoglycans.

Relationship between photomutagenicity and photocarcinogenicity

作者: Loveday, Kenneth S.

A review with 32 references on photomutagenicity and photocarcinogenicity of psoralens and fluoroquinolones, risk assessment for new drugs, and genotoxic and nongenotoxic photocarcinogens.

100 项与 Creative Biomolecules 相关的药物交易

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100 项与 Creative Biomolecules 相关的转化医学

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