更新于：2024-11-01

Sankara Eye Hospital

India

更新于：2024-11-01

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项与 Sankara Eye Hospital 相关的临床试验

CTRI/2024/10/075127 / Not yet recruitingN/AIIT

Functional and Anatomical outcomes in a complex Rhegmatogenous retinal detachments (RRD) managed by retaining perfluorocarbon liquid (PFCL) tamponade for 2 weeks. - NIL

开始日期2024-10-24

申办/合作机构

Sankara Eye Hospital

CTRI/2024/09/074457 / Not yet recruitingN/AIIT

Assessing implications for prognosis and management of non-infectious uveitis based on novel inflammatory serum biomarkers. - NIL

开始日期2024-10-10

申办/合作机构

Sankara Eye Hospital

CTRI/2024/08/072314 / Not yet recruitingN/AIIT

Ganglion Cell Complex thickness in Indian Patients on Hydroxychloroquine and its Correlation with Vessel Density on OCTA – A comparative cross-sectional study - NIL

开始日期2024-09-16

申办/合作机构

Sankara Eye Hospital

100 项与 Sankara Eye Hospital 相关的临床结果

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337

项与 Sankara Eye Hospital 相关的文献（医药）

2024-10-01·Indian Journal of Ophthalmology

Volume measurement of the vitrectomised eye and its applications in practice

Article

作者: Sagar, Pradeep ; Ravishankar, HN ; Agrawal, Surbhi ; Ramanjulu, Rajesh ; Sahare, Harshal ; Shanmugam, P Mahesh ; Mishra, Divyansh Kailashchandra ; Suryakanth, Shwetha

Purpose:To estimate the vitreous cavity replacement volume after pars plana vitrectomy and analyze its correlation with axial length and refractive error.Methods:Observational cross-sectional study on 103 eyes undergoing vitrectomy. Fluid-air exchange was performed using a soft-tip cannula connected to a PVC tubing, the distal end of which opened into a 10-cc syringe without the plunger. The collected fluid was measured (and correction factors applied) to estimate the vitreous cavity volume.Results:The mean axial length of 103 eyes was 23.43 ± 1.54 mm. The mean vitreous cavity volume was 4.46 ± 0.83 mL (2.8–8.1 mL). There was a strong positive correlation between axial length and vitreous volume, which was stronger for pseudophakic and aphakic groups than for phakic groups.Conclusion:Accurate assessment of vitreous cavity volume can enable precise quantification of tamponade, intravitreal drugs, and intravitreal chemotherapeutic agents. This will allow better surgical outcomes, decreased toxicity, and increased cost-effectiveness due to lesser wastage.Objective:To estimate the vitreous cavity replacement volume after pars plana vitrectomy and analyze its correlation with axial length and refractive error.

2024-10-01·Indian Journal of Ophthalmology

Evaluation of antioxidant status of lens epithelial cells in cataract patients

Article

作者: Jadhao, Avinash Namdeo ; Patil, Neelam Jayant ; Ramteke, Trupti Diwan ; Sorte Gawali, Kranti Santosh ; Sahare, Harshal

Purpose:The main factor that causes cataracts is the increased oxidative stress and imbalance of an antioxidant defense mechanism, which leads to significant changes in the lens microarchitecture. Senile cataract is the most common type of acquired cataracts due to aging.Methods:We carried out a case–control study in the biochemistry department to examine the antioxidant status (catalase and total antioxidant capacity [TAC]) and lipid peroxidation marker, that is, malondialdehyde (MDA) in human lens epithelial cells (HLECs) of different grades of senile cortical, nuclear, and posterior subcapsular cataracts. We collected 150 samples from patients aged 50–90 years. These included 50 samples of cortical cataracts, 50 of nuclear cataracts, and 50 samples of posterior subcapsular cataracts. We measured catalase activity by the Beer method, TAC by the Benzie and Strain method, and protein by the Bradford method. We also estimated TAC in the aqueous extract of HLECs by the ferric reducing ability of plasma (FRAP) method and MDA by the thiobarbituric acid assay method.Results:The results of this study showed that the level of catalase enzyme was higher in the first grade of nuclear, posterior subcapsular, and cortical cataracts than in other grades. This suggests that the catalase enzyme activity drops sharply in the second and third grades of these types of cataracts. The same pattern was observed for TAC, which was higher in the first grade of nuclear, posterior subcapsular, and cortical cataracts than in other grades. There were significant differences between catalase and TAC in different grades of cataracts, indicating that as the grading increases, both catalase and TAC decrease.Conclusion:The results of this study showed that the levels of MDA were higher and the levels of catalase and TAC were lower in patients with more severe cataracts compared to the healthy controls.

2024-09-01·Journal of Clinical Ophthalmology and Research

Topical three-drug combination in the management of pseudophakic cystoid macular edema

作者: Sane, Siddharth ; Mahalingam, Prabhushanker ; Ganesan, Geetha

The purpose was to report the outcome after usage of three topical eyedrops combination, consisting of one steroid, one carbonic anhydrase inhibitor (CAI), and one non-steroidal anti-inflammatory drug (NSAID) in the treatment of pseudophakic cystoid macula edema (PCME) or Irvine–Gass syndrome. Treatment response monitoring of two patients with PCME to the combination of three eyedrops in a fixed dose regimen done using Optical Coherence Tomography. In both cases, significant improvement was documented within 1 week of starting the treatment, with respect to both visual acuity as well as central macular thickness and intraretinal fluid or cystoid macula edema (CME) resolution. The combination of three topical drugs of difluprednate (steroid), dorzolamide (CAI), and nepafenac (NSAID) is highly effective in treating select cases of pseudophakic CME and negates the need for usage of intravitreal (IVT) or posterior sub-Tenon’s injection of drugs such as triamcinolone acetonide, i.e., IVT triamcinolone acetonide, or posterior subtenon thus avoiding its associated complications.

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