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2

项与 Biomedica Life Sciences SA 相关的药物

99mTc-Demogastrin 2

靶点

CCKB

作用机制

CCKB调节剂 [+1]

在研机构-

原研机构

Biomedica Life Sciences SA

在研适应症-

非在研适应症

造影剂 [+1]

最高研发阶段无进展

首次获批国家/地区-

首次获批日期-

99mTc-Demobesin

靶点

Bombesin receptor

作用机制

蛙皮素受体拮抗剂 [+1]

在研机构-

原研机构

Biomedica Life Sciences SA

在研适应症-

非在研适应症

乳腺癌 [+2]

最高研发阶段无进展

首次获批国家/地区-

首次获批日期-

100 项与 Biomedica Life Sciences SA 相关的临床结果

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0 项与 Biomedica Life Sciences SA 相关的专利（医药）

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3

项与 Biomedica Life Sciences SA 相关的文献（医药）

2006-02-01·Applied Radiation and Isotopes3区 · 工程技术

Study of the labeling of two novel RGD-peptidic derivatives with the precursor [99mTc(H2O)3(CO)3]+ and evaluation for early angiogenesis detection in cancer

3区 · 工程技术

Article

作者: Fani, M. ; Archimandritis, S. C. ; Psimadas, D. ; Zikos, C. ; Varvarigou, A. D. ; Xanthopoulos, S.

In the initial stages of tumor formation, overexpression of integrins identifying the RGD sequence (Arg-Gly-Asp) is observed. The aim of the present study was the synthesis and labeling of two novel RGD derivatives, via the precursor [99mTc(H2O)3(CO)3]+, as well as the radiochemical and radiopharmacological evaluation of the labeled products. The labeling led to the formation of a single product in each case (>98%), with noteworthy in vitro stability, fast blood clearance and elimination by the hepatobiliary and the urinary systems.

Anticancer Research

Comparative evaluation of linear and cyclic Tc-RGD peptides for targeting of integrins in tumor angiogenesis

作者: Xanthopoulos, Stavros ; Bouziotis, Penelope ; Loudos, George K. ; Zikos, Christos ; Psimadas, Dimitrios ; Fani, Melpomeni ; Varvarigou, Alexandra D.

Cell adhesion mols., such as integrins, play a vital role in angiogenesis, a key pathway for tumor growth, invasion and metastasis.The integrin α_vβ₃, which recognizes the RGD sequence (Arg-Gly-Asp), may provide a target for in vivo tumor imaging.A linear and a cyclic RGD peptide derivative (RGDfK-His and cRGDfK-His, resp.), labeled via the precursor [^99mTc(H₂O)₃(CO)₃]⁺, were comparatively evaluated and their radiobiol. properties were assessed in normal and tumor-bearing mice.Biodistribution studies showed non-specific uptake in all organs, rapid blood clearance and elimination via the hepatobiliary and urinary systems.Tumor uptake was higher for the cyclic radiolabeled derivative, as both biodistribution and imaging studies suggested.The cRGDfK-His, labeled via the fac-[^99mTc(CO)₃]-core, may prove to be a useful tool for early tumor detection.

Anticancer research

Comparative evaluation of linear and cyclic 99mTc-RGD peptides for targeting of integrins in tumor angiogenesis.

Article

作者: Zikos, Christos ; Bouziotis, Penelope ; Varvarigou, Alexandra D ; Xanthopoulos, Stavros ; Psimadas, Dimitrios ; Fani, Melpomeni ; Loudos, George K

Cell adhesion molecules, such as integrins, play a vital role in angiogenesis, a key pathway for tumor growth, invasion and metastasis. The integrin alpha(v)beta(3), which recognizes the RGD sequence (Arg-Gly-Asp), may provide a target for in vivo tumor imaging. A linear and a cyclic RGD peptide derivative (RGDfK-His and cRGDfK-His, respectively), labelled via the precursor [99mTc(H2O)3(CO)3]+, were comparatively evaluated and their radiobiological properties were assessed in normal and tumor-bearing mice. Biodistribution studies showed non-specific uptake in all organs, rapid blood clearance and elimination via the hepatobiliary and urinary systems. Tumor uptake was higher for the cyclic radiolabelled derivative, as the both biodistribution and imaging studies suggested. The cRGDfK-His, labelled via the fac-[99mTc(CO)3]-core, may prove to be a useful tool for early tumor detection.

100 项与 Biomedica Life Sciences SA 相关的药物交易

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100 项与 Biomedica Life Sciences SA 相关的转化医学

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