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疾病领域	数量

内分泌与代谢疾病	1
肿瘤	1

排名前五的药物类型	数量

小分子化药	1

排名前五的靶点	数量

GPSM1	1

关联

1

项与 Government College University 相关的药物

AN-465

靶点

GPSM1

作用机制

GPSM1 modulators

在研机构

Tessa Therapeutics Ltd [+1]

原研机构

上海交通大学

在研适应症

糖尿病 [+1]

非在研适应症-

最高研发阶段临床前

首次获批国家/地区-

首次获批日期-

100 项与 Government College University 相关的临床结果

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0 项与 Government College University 相关的专利（医药）

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8,788

项与 Government College University 相关的文献（医药）

2025-01-01·Journal of Molecular Structure

Convergent synthesis, kinetics and computational attributions of indole-N-phenyltriazole hybrids bearing N-(aryl)butanamides as alkaline phosphatase inhibitors

作者: Raza, Hussain ; Shahid, Muhammad ; Nazir, Majid ; Siddiqui, Sabahat Zahra ; Ayine-Tora, Daniel Moscoh ; Aziz-ur-Rehman ; Shakila ; Abbasi, Muhammad Athar ; Shah, Syed Adnan Ali ; Kim, Song Ja

In the research delineate herein, an innovative sequence of new series of multi-functional target mols. (9a-i) having indole-N-phenyltriazole bi-heterocyclic hybrids unified with N-arylated butanamides was synthesized as alk. phosphatase inhibitor.The structural validation of all the formulated compounds was accomplished through IR, EI-MS, ¹H NMR, ¹³C NMR and CHN anal. data.The in vitro enzyme inhibitory investigation revealed the efficacy of these bi-heterocyclic derivatives, 9a-i, as potent inhibitors of alk. phosphatase relative to the standard used.The compound 9h was found to be the most active compound (IC₅₀ = 0.062 ± 0.017 μM), and its inhibitory activity is about 10 times higher than potassium dihydrogen phosphate (KH₂PO₄) (IC₅₀ = 5.251 ± 0.468 μM).The kinetics mechanism was attributed by evaluating the Lineweaver-Burk plots, which revealed that compound 9h inhibited the alk. phosphatase non-competitively to form an enzyme-inhibitor complex.The inhibition constant K_i determined from Dixon plots for this compound was 0.045 μM.The computational study was in full agreement with the exptl. records and these ligands exhibited good interactions and binding energy values.These mols. also demonstrated mild cytotoxicity toward red blood cell membranes when analyzed through hemolysis.So, based on the presented results, these mols., being the promising inhibitors of alk. phosphatase, might be deliberated as suitable medicinal scaffolds to render normal calcification of bones and teeth.

2024-12-31·Cogent Food & Agriculture

Nutraceutical properties, biological activities, and industrial applications of chickpea protein

作者: Anwer, Kainat ; Iqbal, Touseef ; Akram, Sidra ; Madilo, Felix Kwashie ; Kousar, Safura ; Khalid, Muhammad Zubair ; Afzal, Muhammad Faizan ; Elawad, Mohammed Ahmed ; Ahmed, Alshebli ; Khalid, Waseem ; Zubair, Muhammad ; Farman, Laiba

The demand for protein has increased over last few years.Plant-based proteins are appreciated to meet the increasing demand of proteins than animal protein with the growing population worldwide.Pulses are one of the good sources of protein.Chickpea is one of the oldest and most cultivated legume crops consumed as source of protein.Chickpeas can be classified into two types named as ′kabuli′ and ′desi′ on the basis of their phys. parameters.They are recognized as a valuable dietary protein source due to their sufficient biol. value, and protein bioavailability.Chickpeas contain a variety of bioactive compounds, including isoflavones and phenolic acid.Generally, chickpea and pulses serve as viable options for functional and nutritional proteins.Chickpea proteins are considered as the best alternative to animal proteins with high amino acid profile and cost effectiveness.They are significant in academic and food business domains.Chickpea protein isolates are commonly identified as having a min. protein content of 90% on a dry weight basis.They offer excellent functional and therapeutic potential in mitigating various health ailments.Chickpea protein is also used in production of value-added products in various food industries including baking industries, meat industry, infant formula and nutraceutical industries.This review explores the production, nutritional composition, health perspectives and industrial applications of chickpea protein.

2024-12-31·International Journal of Food Properties

Potential of ascorbic acid in human health against different diseases: an updated narrative review

作者: Mubeen, Umber ; Babar, Quratulain ; Ali, Anwar ; Manzoor, Muhammad Faisal ; Fatima, Maleeha ; Madilo, Felix Kwashie ; Riaz, Sakhawat ; Zubair Khalid, Muhammad ; Khalid, Waseem

A review.Ascorbic acid (vitamin C) is the most crucial antioxidant for the body.The biochem. capabilities of ascorbic acid are still being studied.It acts as a cofactor for many enzymes participating in various physiol. functions.This review presents how ascorbic acid is a cofactor for multiple enzymes involved in numerous human activities.Ascorbic acid protects the immune system, reduces allergic reaction severity and assists the fight against infections and other disorders.Ascorbic acid is metabolized by several procedures in the gastrointestinal tract.Eukaryotes produce ascorbic acid via L-galactose (L-Gal) and GDP-D-mannose as part of its metabolic process.It is disseminated throughout the body cells after being readily absorbed by the digestive system.This review will uncover ascorbic acid's biol. functions and metabolism in humans.

100 项与 Government College University 相关的药物交易

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100 项与 Government College University 相关的转化医学

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