Article
作者: Chu, Helen Y ; O’Callaghan-Gordo, Cristina ; Al Amad, Mohammed ; Thamthitiwat, Somsak ; Khuri-Bulos, Najwa ; Chowdhury, Fahmida ; Grigolli-Cesar, Reginna ; Ozturk Kartal, G ; Raboni, Sonia M ; Stolyarov, Kirill ; Gordon, Aubree ; Gun, Emrah ; Emukule, Gideon O ; Palomino, Rubén Lasso ; Otieno, Grieven P ; Gill, Christopher J ; Kotloff, Karen L ; Hawkes, Michael ; Mahtab, Sana ; da Costa Oliveira, Maria Tereza ; Bezerra Duarte, Maria do Carmo Menezes ; Al Serouri, Abdul Wahed ; Ojeda, Jenny ; Noyola, Daniel E ; O’Brien, Katherine L ; El Arifeen, Shams ; Rubio, Franco Díaz ; Das, Rashmi Ranjan ; Dbaibo, Ghassan S ; Borgi, Aida ; Verma, Sheetal ; Breiman, Robert F ; Onyango, Dickens ; Diagbouga, Serge ; da Silva, Daniella Gregória Bomfim Prado ; Monteverde, Nicolás ; Satav, Ashish ; Sánchez, José Félix ; Pardo-Carrero, Rosalba ; Mazur, Natalie I ; Chaves, Sandra ; Saha, Senjuti ; Obodai, Evangeline ; Lupisan, Socorro P ; Weber, Martin W ; Omer, Saad ; Pires, Márcia Rosane ; Simões, Eric A F ; de Mora, Domenica ; de Matos Bezerra, Patricia Gomes ; Toh, Teck-Hock ; Pham, Minh-Hong ; Lucero, Marilla G ; Islam, Md Ariful ; Yuan, Chiang Chun ; Sturm-Ramirez, Katharine M ; Gurley, Emily S ; Duyu, Muhterem ; Saha, Samir K ; Wanlapakorn, Nasamon ; Ali, Asad ; Webler, Jane Melissa ; Giamberardino, Heloisa Ihle Garcia ; Visser, Adele ; Messaoudi, Melina ; Gökçe, Şule ; Blau, Dianna M ; Tran, Tuan ; Gessner, Bradford D ; Sow, Samba O ; Mussá, Tufária ; Sampath Jayaweera, J A A ; Zemanate, Eliana ; Tall, Haoua ; Mandomando, Inacio ; Bassat, Quique ; de Freitas Lázaro Emediato, Carla Cecília ; Menta, Soledad ; Venter, Marietjie ; Su, Wei ; Löwensteyn, Yvette N ; Bryant, Juliet ; Munywoki, Patrick K ; Eşki, Aykut ; Lucion, Maria Florencia ; Madhi, Shabir A ; Kendirli, Tanil ; Mwananyanda, Lawrence M ; Vásquez-Hoyos, Pablo ; Tippet Barr, Beth A ; Ai, Junhong ; de Xie, Zheng ; Forman, Leah ; Perales, José Gareca ; Sam, Jamal I-Ching ; Willemsen, Joukje E ; Polack, Fernando P ; Ogbuanu, Ikechukwu ; Yit, Jeffrey Lee Soon ; Karsies, Todd ; Dhole, Tapan ; Bruno, Alfredo ; FunChan, Yoke ; de-Paris, Fernanda ; Obando-Belalcazar, Evelyn ; Kelly, Matthew ; Izquierdo, Ledys ; Bont, Louis J ; Oshitani, Katherine L ; Zamora, Lida ; Jaffe, Adam ; Homaira, Nusrat ; Jambai, Amara ; Sagna, Tani ; Moyes, Jocelyn ; Kazi, Abdul Momin ; Odoom, John Kofi ; de Carvalho, Felipe Cotrim ; Assefa, Nega ; Echavarria, Marcela ; Ayari, Ahmed ; Buchwald, Andrea ; Suntarattiwong, Piyarat ; Halasa, Natasha ; Hanna-Wakim, Rima ; Nokes, D James ; de Andrade Nishioka, Sergio ; González-Dambrauskas, Sebastián ; Ismail, Maha Talaat ; Jarovsky, Daniel ; Fernandez-Sarmiento, Jaime ; Gentile, Angela ; Cohen, Cheryl ; Caballero, Mauricio T ; Aamir, Uzma Bashir ; Scott, J Anthony G
AbstractBackgroundRespiratory syncytial virus (RSV) is a leading cause of pediatric death, with >99% of mortality occurring in low- and lower middle-income countries. At least half of RSV-related deaths are estimated to occur in the community, but clinical characteristics of this group of children remain poorly characterized.MethodsThe RSV Global Online Mortality Database (RSV GOLD), a global registry of under-5 children who have died with RSV-related illness, describes clinical characteristics of children dying of RSV through global data sharing. RSV GOLD acts as a collaborative platform for global deaths, including community mortality studies described in this supplement. We aimed to compare the age distribution of infant deaths <6 months occurring in the community with in-hospital.ResultsWe studied 829 RSV-related deaths <1 year of age from 38 developing countries, including 166 community deaths from 12 countries. There were 629 deaths that occurred <6 months, of which 156 (25%) occurred in the community. Among infants who died before 6 months of age, median age at death in the community (1.5 months; IQR: 0.8−3.3) was lower than in-hospital (2.4 months; IQR: 1.5−4.0; P < .0001). The proportion of neonatal deaths was higher in the community (29%, 46/156) than in-hospital (12%, 57/473, P < 0.0001).ConclusionsWe observed that children in the community die at a younger age. We expect that maternal vaccination or immunoprophylaxis against RSV will have a larger impact on RSV-related mortality in the community than in-hospital. This case series of RSV-related community deaths, made possible through global data sharing, allowed us to assess the potential impact of future RSV vaccines.