This prospective, double-blind, parallel-group controlled trial aims to investigate the consequence of early trauma on dopamine release evoked by positive valence odors.

开始日期2024-12-01

申办/合作机构

Centre Hospitalier le Vinatier

NCT05159830

/ Not yet recruiting临床2期IIT

Cannabidiol for Reducing Drinking in Alcohol Use Disorder and Modifying the Effects of Alcohol on the Brain and the Liver: a Phase 2 Clinical Trial.-The CARAMEL Study

The non-psychotomimetic cannabis compound cannabidiol (CBD) has been found effective for reducing alcohol drinking in mice. Moreover, other experimental studies have found that CBD reduced alcohol-induced steatosis in the liver, and reduced alcohol-related injury in the brain. Despite these promising results from animal data, no human study has been conducted yet in alcohol use disorder (AUD).

开始日期2024-10-31

申办/合作机构

Centre Hospitalier le Vinatier

NCT06499051

/ RecruitingN/AIIT

Epidemiology of Sexual Offenders. A Cross-sectional Study of Auvergne-Rhône-Alpes Referral Platforms

The epidemiology of sexual offenders has been poorly studied in the literature. A retrospective and prospective study will allow for the examination of the clinical profile of sexual offense perpetrators, risk and recurrence factors, as well as psychiatric or medical treatment. Since 2015, the Auvergne-Rhône-Alpes region has 8 reference platforms for sexual offense perpetrators, offering personalized assessment according to criteria defined by the Regional Health Agency (ARS). After this assessment, a multidisciplinary meeting is organized to define a tailored care plan. This study, called ARAVS (Auvergne Rhone-Alpes Sexual Offenders), aims to conduct an epidemiological, clinical, and socio-demographic study of patients in these platforms.

开始日期2024-05-10

申办/合作机构

Centre Hospitalier le Vinatier

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324

项与 Centre Hospitalier le Vinatier 相关的文献（医药）

2024-10-01·International Journal of Transgender Health

Gynecological primary care of trans men and transmasculine non-binary individuals, a French descriptive study

Article

作者: Oriol, Séverine ; Cuq, Juliette ; Morel-Journel, Nicolas ; Neuville, Paul ; Jurek, Lucie

IntroductionGynecological primary care is a public health issue, however, there is no French data on the transmasculine population, despite identified needs and a low coverage rate described in the international literature. The objective was to analyze the access of the French transmasculine population to gynecological primary care.MethodsThe study "Trans men and Transmasculine non-binary individuals use and access to prevention and sexual health care 2022" is a non-interventional, self-administrated, anonymous online study targeting transmasculine adults living in France. Participants were recruited via social networks, LGBTQIA + associations, the FPATH and a caregivers network.ResultsA total of 622 surveys were included, the participants were mostly young (mean age: 25 years old), single (77%), students (40%), owners or tenants (73%) and living in large cities (47%). Among them, 77% had a cross-sex hormonal therapy, 41% underwent a torsoplasty and 6% a pelvic surgery. Only 26% of the participants had an up-to-date follow-up, while 40% never had access to a gynecological consultation. Only a quarter (26%) of the 25-65 years old population, targeted by secondary prevention for cervical cancer, had at least one cervical test in their lifetime. Moreover, regarding feedbacks about gynecological follow-up, they expressed its pertinence but also reported a low comfort level.ConclusionsThis study highlighted the low access to gynecological primary care of a young transmasculine population in France. There is an urgent need of follow-up within this population, by increasing the education of health professionals and developing prevention programs.

2024-09-01·Journal of the American Academy of Child & Adolescent Psychiatry

Global Perspectives, Local Policies: The Complexities of Race and Ethnicity in Research

Letter

作者: Jurek, Lucie ; Leaune, Edouard

The recent article by Riccioni et al.¹ entitled "Systematic Review and Meta-Analysis: Reporting and Representation of Race/Ethnicity in 310 Randomized Controlled Trials of Attention-Deficit/Hyperactivity Disorder Medications" highlights the gaps and disparities in the inclusion and reporting of racial and ethnic data in clinical research, using the example of research on attention-deficit/hyperactivity disorder pharmacological treatment. The authors emphasized the underreporting of data on race and ethnicity in randomized controlled trials on attention-deficit/hyperactivity disorder medications and the overrepresentation of White participants. Their thorough analysis serves as a vital call to action for enhancing representativeness and transparency in research, ensuring that findings are both comprehensive and applicable to diverse populations. However, while the intent to improve inclusivity in clinical trials is universally important, implementing this can be challenging, especially when considering the varied legal and cultural landscapes across different countries.

2024-08-01·Brain Research

Implicit and explicit motor imagery ability after SCI: Moving the elbow makes the difference

Article

作者: Gelis, Anthony ; Henkous, Sonia ; Di Rienzo, Franck ; Guillot, Aymeric ; Rode, Gilles ; Mateo, Sébastien ; Daligault, Sébastien ; Collet, Christian

Cervical spinal cord injury (SCI) causes dramatic sensorimotor deficits that restrict both activity and participation. Restoring activity and participation requires extensive upper limb rehabilitation focusing elbow and wrist movements, which can include motor imagery. Yet, it remains unclear whether MI ability is impaired or spared after SCI. We investigated implicit and explicit MI ability in individuals with C6 or C7 SCI (SCI_C6 and SCI_C7 groups), as well as in age- and gender-matched controls without SCI. Inspired by previous studies, implicit MI evaluations involved hand laterality judgments, hand orientation judgments (HOJT) and hand-object interaction judgments. Explicit MI evaluations involved mental chronometry assessments of physically possible or impossible movements due to the paralysis of upper limb muscles in both groups of participants with SCI. HOJT was the paradigm in which implicit MI ability profiles differed the most between groups, particularly in the SCI_C6 group who had impaired elbow movements in the horizontal plane. MI ability profiles were similar between groups for explicit MI evaluations, but reflected task familiarity with higher durations in the case of unfamiliar movements in controls or attempt to perform movements which were no longer possible in persons with SCI. Present results, obtained from a homogeneous population of individuals with SCI, suggest that people with long-term SCI rely on embodied cognitive motor strategies, similar to controls. Differences found in behavioral response pattern during implicit MI mirrored the actual motor deficit, particularly during tasks that involved internal representations of affected body parts.

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