Hong Kong Jockey Club Institute of Chinese Medicine Ltd. (香港赛马会中药研究院有限公司)

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100 项与香港赛马会中药研究院有限公司相关的临床结果

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0 项与香港赛马会中药研究院有限公司相关的专利（医药）

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项与香港赛马会中药研究院有限公司相关的文献（医药）

2012-04-01·Diabetes1区 · 医学

Sustained Antidiabetic Effects of a Berberine-Containing Chinese Herbal Medicine Through Regulation of Hepatic Gene Expression

1区 · 医学

Article

作者: Guan, Jing ; Yip, Kevin Y. ; Tsui, Stephen K.W. ; Leung, Ross K.K. ; Lee, Heung-Man ; Tong, Peter C.Y. ; Qiao, Chun-Feng ; Xu, Hong-Xi ; Wong, Harriet K.T. ; He, Lan ; Siu, Jennifer J. ; Sui, Yi ; Zhu, Xun ; Chan, Juliana C.N. ; Liu, Li-Zhong ; Zhao, Hai-Lu

Diabetes and obesity are complex diseases associated with insulin resistance and fatty liver. The latter is characterized by dysregulation of the Akt, AMP-activated protein kinase (AMPK), and IGF-I pathways and expression of microRNAs (miRNAs). In China, multicomponent traditional Chinese medicine (TCM) has been used to treat diabetes for centuries. In this study, we used a three-herb, berberine-containing TCM to treat male Zucker diabetic fatty rats. TCM showed sustained glucose-lowering effects for 1 week after a single-dose treatment. Two-week treatment attenuated insulin resistance and fatty degeneration, with hepatocyte regeneration lasting for 1 month posttreatment. These beneficial effects persisted for 1 year after 1-month treatment. Two-week treatment with TCM was associated with activation of AMPK, Akt, and insulin-like growth factor-binding protein (IGFBP)1 pathways, with downregulation of miR29-b and expression of a gene network implicated in cell cycle, intermediary, and NADPH metabolism with normalization of CYP7a1 and IGFBP1 expression. These concerted changes in mRNA, miRNA, and proteins may explain the sustained effects of TCM in favor of cell survival, increased glucose uptake, and lipid oxidation/catabolism with improved insulin sensitivity and liver regeneration. These novel findings suggest that multicomponent TCM may be a useful tool to unravel genome regulation and expression in complex diseases.

2011-04-01·Cladistics1区 · 生物学

Applying plant DNA barcodes for Rosaceae species identification

1区 · 生物学

Review

作者: Xu, Hongxi ; Chen, Shilin ; Song, Jingyuan ; Zhu, Yingjie ; Huang, Linfang ; Pang, Xiaohui

© The Willi Hennig Society 2010. ABSTRACT: The Consortium for the Barcode of Life (CBOL) Plant Working Group (PWG) established the use of matK+rbcL as core barcodes and ITS2 as one of the supplementary loci for differentiating plants at the Third International Barcoding Conference. Here, we tested the applicability of four DNA regions (rbcL, matK, rpoC1 and ITS2) as the barcodes for identifying species within Rosaceae. Based on assessments of the success rates of PCR amplifications, the sequence quality, extent of specific genetic divergence, DNA barcoding gap and ability for species discrimination, our results suggest that ITS2 is the best of the four loci tested for barcoding Rosaceae. We further evaluated the effectiveness of ITS2 for identifying a wide range of species within Rosaceae. Of the 1410 plant samples collected from 893 species in 96 diverse genera, ITS2 successfully identified 78 and 100% of them at the species and genus levels, respectively. Therefore, our research indicated that the ITS2 region is a powerful, though not perfect, barcode for Rosaceae identification that also contributes valuable information for identifying closely related species in other plant taxonomic groups.

2010-05-01·Tetrahedron Letters

Novel polyisoprenylated benzophenone derivatives from Garcinia paucinervis

作者: Pu, Jian-Xin ; Liu, Xin ; Qiao, Chun-Feng ; Lai, Fanny Shuk Fan ; Xu, Hong-Xi ; Zhou, Yan ; Gao, Xue-Mei ; Luo, Kathy Qian ; Song, Jing-Zheng ; Yu, Ting

Four novel polyisoprenylated benzophenone derivatives, paucinones A-D (1-4), were isolated from the leaves of the plant Garcinia paucinervis.Paucinones A-C (1-3) contained an unexpected cyclohexane-spiro-tetrahydrofuran moiety.A 1-methylene-3,3-dimethylcyclohexane group never reported before was found in the structure of paucinone D (4).The structures of these compounds were elucidated with spectroscopic evidences.The relative stereochemistries of 1-4 were determined by NOESY correlations.These compounds showed significant cytotoxicities against HeLa cells.

100 项与香港赛马会中药研究院有限公司相关的药物交易

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100 项与香港赛马会中药研究院有限公司相关的转化医学

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