A Prospective Comparative Placebo controlled clinical study to evaluate the efficacy and safety of Zincovit ACTIVE Instant Rehydration Solution in Fatigue/Stress - Nil

开始日期2024-06-05

申办/合作机构

Apex Laboratories Pvt Ltd.

CTRI/2024/02/063149 / Not yet recruiting临床4期

A Prescription Event Monitoring (PEM) Study to Evaluate the Effects of Adjuvant Therapy with ZincorespTM Tablets in Patients Having Recurrent Respiratory Disorders and Infections. - NA

开始日期2024-03-05

申办/合作机构

Apex Laboratories Pvt Ltd.

CTRI/2024/02/063092 / Not yet recruiting临床4期

A Prescription Event Monitoring (PEM) Study to Evaluate the Effects of Adjuvant Therapy with ZincorespTM Tablets/ Syrup in Patients Having Recurrent Ear, Nose, Throat and Respiratory Disorders and Infections. - NA

开始日期2024-02-29

申办/合作机构

Apex Laboratories Pvt Ltd.

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项与 Apex Laboratories Pvt Ltd. 相关的文献（医药）

2021-09-30·Biomedical and Pharmacology Journal

Acute and Repeated Dose Toxicity Study of Clevira Syrup – A Polyherbal Formulation

作者: K M, Nagarajan ; .R, Mirunalini ; K, Sakthibalan ; V, Subha. ; JV, Sabarianandh ; Manimekalai, K. ; Narayanamurthy, Uma ; Paul. C, Arther

Aim and Objectives: This study evaluated the acute and repeated dose toxicity effects of Clevira Syrup Polyherbal formulation (CSPHF), which was prepared from ten different herbs, well known and widely used in traditional medicine for the management of viral infections and other inflammatory disease conditions. Individually these herbs (Carica papaya, Melia azedarach, Andrographis paniculata, Vetiveria zizanioides, Trichosanthes dioica, Cyperus rotundus, Zingiber officinale, Piper nigrum, Mollugo Cerviana and Tinospora cordifolia )were completely safe, but the polyherbal formulation effects were not known. Thus, this study was done for the investigation of toxicological profile of CSPHF in Wistar Albino rats. Methods: As per OECD(Organisation for Economic Co-operation and Development) guidelines 423 and 407, Acute and Repeated dose toxicity study were proceeded. In the acute toxicity study a single dose of CSPHF (2000mg/kg) was administered orally to female Wistar rats and in repeated dose toxicity study, CSPHF was administered orally in Control group and three different doses (1000, 500 and 250mg/kg body weight) to both male and female wistar albino rats for 28 days. At the end of the study, the animals were euthanized, observed the external and internal morphology (Acute Toxicity) and assessed the effect of CSPHF on histopathological and biochemical parameters (Repeated Dose toxicity study). Results: In acute toxicity study, there were no visual signs of toxicity of CSPHF (2000mg/kg) observed, whereas in Repeated dose toxicity study Ischaemia, inflammation and hematoma of the internal organs were observed at 1000mg/kg dose, but no such toxic features were seen at 500 and 250mg/kg dose of CSPHF. Conclusion: The results of the Acute and Repeated Dose toxicity study could be authenticated in future studies, which will be more useful and evidence based for the management of Viral infectionsduring pandemics.

International Journal of Research in Pharmaceutical and Nano Sciences

Formulation and evaluation of nanoparticles containing atenolol by ionic gelation technique

作者: Ilavarasan, P. ; Shaik, Sheema Meenaz ; Sabarikumar, K.

Nanoparticles of atenolol, an antihypertensive agent were prepared to improve absorption and to increase bioavailability.The drug nanoparticles were prepared using chitosan polymer by ionic gelation technique.Nanoparticles of different ratios were formulated and analyzed for drug content, entrapment efficiency, particle size, zeta potential and in vitro drug release studies.The particle size ranged between 156±2 to 321±6 nm.The entrapment efficiency of FAN-1 to FAN-5 was ranging from 94.5±0.12 to 99.2±0.23.The drug release studies it was observed that prepared nanoparticles formulation-5 (FAN-5) shows better sustained release (98.75%) for about 24 h as compared to other formulations.

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