Currently, the principal strategy for immune checkpoint inhibitors (ICI)-related dermatitis include systemic use of corticosteroids, which can impair the efficacy of preceding ICIs treatment. Janus kinase inhibitors (JAKi) could be the optimal option for ICI-related dermatitis, which can not only provide rapid relief for ICI-related dermatitis but also potentially enhance the anti-tumor efficacy of ICIs. This is an open-lable, single arm, phase II trial, aims to evaluate efficacy and safety of JAK inhibitors for solid malignant tumor patients with ICI-related dermatitis.

开始日期2024-12-01

申办/合作机构

杭州肿瘤医院

NCT05749445

/ RecruitingN/AIIT

Appropriate Evaluation of Antiviral Therapy With Nirmatrelvir-ritonavir in Hospitalized Patients: a Multicenter Retrospective Study in China

The primary objective of the study was to assess the appropriateness of antiviral therapy with nirmatrelvir-ritonavir in hospitalized patients.

开始日期2022-12-15

申办/合作机构

杭州市第一人民医院（西湖大学附属杭州市第一人民医院）

[+2]

NCT05588206

/ Recruiting临床1/2期IIT

Dose-escalation by Hypofractionated Stereotactic Radiotherapy Simultaneous Integrated Boost IMRT for Brain Metastases in Non Small Cell Lung Cancer：A Phase I Study

The objective of this trial is to assess the safety and feasibility of delivering SBRT to patients with limited BMs (less than 10 lesions of lung cancer) by establishing the maximally tolerated dose (MTD) of SABR in 5 fractions.

开始日期2022-01-01

申办/合作机构

杭州市第一人民医院（西湖大学附属杭州市第一人民医院）

[+1]

100 项与杭州肿瘤医院相关的临床结果

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0 项与杭州肿瘤医院相关的专利（医药）

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135

项与杭州肿瘤医院相关的文献（医药）

2025-05-01·Biochemical and Biophysical Research Communications

Formononetin prevents intestinal injury caused by radiotherapy in colorectal cancer mice via the Keap1-Nrf2 signaling pathway

Article

作者: Lou, Jun ; Yu, Qingqing ; Zhao, Linfang ; Mo, Weixing ; Zhang, Lidan ; Zhang, Ke ; Li, Lingdi ; Tang, Rongjun

Radiation-induced intestinal injury (RIII) is a serious complication of radiation therapy. Formononetin (FT) is a methoxy isoflavone with anti-tumor and anti-oxidant properties. This study explored whether FT reduces ROS by activating the Keap1/Nrf2 pathway and thereby protecting against RIII. 30 BABL/C mice were used to construct a colorectal cancer model with CT26 cells and validated the model on day 7. Then, the cancer model mice were divided into 3 groups on day 14 (model control, model, and model + FT) with administration of FT or saline and radiated them on day 21. All samples were collected on day 28. Mechanical intestinal barrier assessed via intestinal absorption function, HE staining, and Claudin-1, Occludin, ZO-1 expression. Apoptosis was measured by TUNEL and cleaved-caspase 3, angiogenesis by CD31, and oxidative stress by NO and ROS levels. Keap1, Nrf2 (cytoplasm) and Nrf2 (nucleus) expression were measured by Western blot. FT treatment enhanced absorption and reduced damage and apoptosis in intestinal tissue. During FT treatment, inhibition of NO and ROS leads to suppression of oxidative stress and promotion of CD31 expression promotes angiogenesis. FT upregulated the expression of nuclear Nrf2 and reduced cytoplasmic Keap1 and Nrf2. FT strengthens mechanical barrier and decreases oxidative stress in intestinal tissue, providing radiation injury protection. Its anti-radiation effect may be through Keap1/Nrf2 pathway activation.

2025-04-07·Oncogene

Cellular polarity pilots breast cancer progression and immunosuppression

Review

作者: Shen, Juan ; Li, Jian Jian ; Lee, Maya ; Huang, Jie ; Ma, Shenglin ; Sun, Lun-Quan ; Luo, Shufeng ; Chen, Rachel

AbstractDisrupted cellular polarity (DCP) is a hallmark of solid cancer, the malignant disease of epithelial tissues, which occupies ~90% of all human cancers. DCP has been identified to affect not only the cancer cell’s aggressive behavior but also the migration and infiltration of immune cells, although the precise mechanism of DCP-affected tumor-immune cell interaction remains unclear. This review discusses immunosuppressive tumor microenvironments (TME) caused by DCP-driven tumor cell proliferation with DCP-impaired immune cell functions. We will revisit the fundamental roles of cell polarity (CP) proteins in sustaining mammary luminal homeostasis, epithelial transformation, and breast cancer progression. Then, the current data on CP involvement in immune cell activation, maturation, migration, and tumor infiltration are evaluated. The CP status on the immune effector cells and their targeted tumor cells are highlighted in tumor immune regulation, including the antigen presentation and the formation of immune synapses (IS). CP-regulated antigen presentation and delivery and the formation of IS between the immune cells, especially between the immune effectors and tumor cells, will be addressed. Alterations of CP on the tumor cells, infiltrated immune effector cells, or both are discussed with these aspects. We conclude that CP-mediated tumor aggressiveness coupled with DCP-impaired immune cell disability may decide the degree of immunosuppressive status and responsiveness to immune checkpoint blockade (ICB). Further elucidating the dynamics of CP- or DCP-mediated immune regulation in TME will provide more critical insights into tumor-immune cell dynamics, which is required to invent more effective approaches for cancer immunotherapy.

2025-04-04·Medicine

Analysis of risk factors for gastrointestinal bleeding in percutaneous coronary intervention patients treated with dual antiplatelet therapy after surgery

Article

作者: Fan, Huimin ; Shuai, Renya ; Chen, Caiping

Following percutaneous coronary intervention (PCI), dual antiplatelet therapy (DAPT) is key to preventing thrombosis. However, the use of DAPT is strongly associated with an increased risk of Gastrointestinal Bleeding, which not only affects patient recovery but also increases the healthcare burden. This study aims to determine the influence of past medical history and factors during hospitalization on the development of postoperative GIB in patients undergoing PCI with DAPT. A total of 380 patients were collected in this study. A total of 42 patients developed GIB during the 1-year follow-up period. Preoperative and postoperative clinical data and past medical history of patients were collected to study the correlates affecting the occurrence of GIB in the postoperative period in patients undergoing PCI with DAPT and to establish a prediction model. Single-factor logistic regression analysis showed: gender, age, past history of bleeding, past history of cancer or tumor, smoking history, history of heart failure, history of PPI use, renal insufficiency, and hypoproteinemia are potential risk factors that may influence the occurrence of GIB postoperatively in patients undergoing DAPT for PCI, P < .2. The data obtained were further included in multi-factor logistic regression analysis: gender (female), past history of bleeding, past history of cancer or tumor, smoking history, heart failure, renal insufficiency were independent risk factors influencing the occurrence of GIB postoperatively in PCI patients undergoing DAPT, P < .05. The findings of this study confirm that gender (female), past history of bleeding, past history of cancer or tumor, smoking history, heart failure and renal insufficiency are independent risk factors for the development of GIB postoperatively in PCI patients undergoing DAPT.

项与杭州肿瘤医院相关的新闻（医药）

2023-09-22

·生物谷

研究人员基于FFPE样本构建甲基化图谱预测癌症原发部位

识别癌症的原发部位对于癌症诊断和后续治疗至关重要。过去二十年中，针对肿瘤抗原的免疫组织化学（IHC）被视为“金标准”（能够判定50-65%的转移癌的原发部位）。 9月14日，《自然-通讯》（Nature Communications）在线发表了中国科学院分子细胞科学卓越创新中心石建涛组完成的最新合作研究成果（DNA methylation profiling to determine the primary sites of metastatic cancers using formalin-fixed paraffin-embedded tissues）。该研究开发了新方法，即利用医学病理学中常用的福尔马林固定石蜡包埋（FFPE）样本，构建DNA甲基化信息图谱，并结合机器学习方法，准确预测转移性癌症的原发部位。识别癌症的原发部位对于癌症诊断和后续治疗至关重要。过去二十年中，针对肿瘤抗原的免疫组织化学（IHC）被视为“金标准”（能够判定50-65%的转移癌的原发部位）。然而，约3-9%的转移癌在临床上无法确定其原发部位，被称为原发灶不明肿瘤（CUP）。开发精准的CUP组织溯源方法，颇具意义。DNA甲基化呈现出较强的组织特异性，是组织溯源理想的分子标志物。该研究对10种常见肿瘤的新鲜冻存样本进行简并甲基化测序（RRBS），构建了高质量的原发灶训练集（n=498）。同时，该工作开发了使用FFPE样本生成DNA甲基化图谱库的方法（FFPE-RRBS），能够检测纳克级高度降解DNA，构建了独立的转移灶验证集（n=215）。进一步，研究利用四种甲基化评估方法和七种机器学习方法构建了28个分类器，其中，基于平均甲基化的线性支持向量机（BELIVE）表现最佳，在转移灶验证集上总体准确度（AUC）达到0.95。该工作开展了前瞻性研究，对68名CUP患者的FFPE样品进行判定发现：敏感度达到81%（top-1）；若考虑前三个预测结果（top-3），敏感度可达93%。研究工作得到国家自然科学基金、浙江省和国家卫生健康委员会等的支持。该研究由中国科学院合肥物质研究院健康与医学技术研究所、分子细胞卓越中心、杭州肿瘤医院合作完成。浙江大学医学院附属杭州市第一人民医院转化医学中心的研究人员参与工作。 BELIVE模型在独立验证集（转移癌）上的预测表现

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