更新于：2024-11-01

Aja University of Medical Sciences

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更新于：2024-11-01

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项与 Aja University of Medical Sciences 相关的临床试验

IRCT20230629058615N3 / Suspended临床3期

Evaluation of the effects of a four-drug regimen with N-acetylcysteine and comparing it with a four-drug regimen in eradicating Helicobacter pylori in patients with Helicobacter pylori infection

开始日期2025-02-19

申办/合作机构

Aja University of Medical Sciences

TCTR20231020004 / Not yet recruiting临床3期

The feasibility and acceptability of a telerehabilitation intervention on patients undergoing total knee arthroplasty in Iran

开始日期2024-05-01

申办/合作机构

Aja University of Medical Sciences

TCTR20231012001临床1期

Comparison of the effect of teaching the basic principles of mechanical ventilation with two Peer-Education and Simulation-Task-Trainer methods on knowledge and performance in nursing students of Aja University of Medical Sciences

开始日期2023-05-03

申办/合作机构

Aja University of Medical Sciences

100 项与 Aja University of Medical Sciences 相关的临床结果

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0 项与 Aja University of Medical Sciences 相关的专利（医药）

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2,939

项与 Aja University of Medical Sciences 相关的文献（医药）

2025-02-01·Current Nutrition & Food Science

Evaluation of Mex A' Mex B Efflux Pump Gene in Pseudomonas aeruginosa Isolated from Milk in Qom Province, Iran

作者: Morovvati, Abbas ; Zargar, Mohsen ; Badi, Alireza ; Dirbaziyan, Ashkan ; Shakib, Pegah

Background:Pseudomonas aeruginosa is an opportunistic pathogen protected from antibiotics' harmful effects by various mechanisms. One of the most important mechanisms is the activation of exudation systems. Therefore, identifying such targets in food contaminating bacteria can help us target them and eliminate bacteria resistant to several drugs, making food safe. Therefore, the present study aimed to trace Mex A and Mex B efflux pump genes in Pseudomonas aeruginosa isolated from dairy products in Qom City, Iran.Methods:300 samples of raw milk, 30 samples of pasteurized milk, and 30 samples of local cream were collected. After a 24-hour culture on nutrient agar and blood agar and performing warm staining, confirmatory biochemical tests were performed to identify bacteria. The disk method was used according to CLSI guidelines to determine the antibiotic sensitivity pattern. Then Mex A and Mex B efflux pump genes were detected using specific primers with PCR technique.Results:117 strains of Pseudomonas aeruginosa were isolated from 300 raw milk samples, and 7 strains were resistant to ciprofloxacin. Out of 117 Pseudomonas aeruginosa isolates, 51 isolates (43.5%) had Mex A gene and 10 isolates (8.5%) had Mex B gene. Three isolates had both Mex A and Mex B genes. Among the strains with resistance to ciprofloxacin (7 isolates), 4 isolates did not have any of the genes. One isolate had Mex A and Mex B genes; 2 isolates were Mex A positive and Mex B negative, and Mex B positive and Mex A negative isolates were not observed.Conclusions:Based on the results, among the studied isolates, the Mex A gene was more abundant. In addition, no significant relationship was found between the existence of Mex A and Mex B genes and ciprofloxacin resistance.

2024-12-07·International Journal of Environmental Analytical Chemistry

Synthesis of new catalyst based on TiO ₂ immobilised in steel slag for photocatalytic degradation of permethrin in aqueous solutions: RSM method

作者: Salarian, Amirahmad ; Esrafili, Ali ; Khaghani, Ramin ; Moslemzadeh, Mehrdad

One of the important causes of Parkinson′s disease is the permethrin pesticide.Therefore, the objective of the present study was to synthesize new catalyst based on TiO₂ immobilized in steel slag (SS) for photocatalytic degradation of permethrin in aqueous solutionsThe experiments were designed by response surface methodol. (RSM) using design expert software.The parameters such as pH, dose (g), concentration of permethrin (mgL^-1) and agitation time were variables of the process, and their optimal conditions were taken by conducting 30 experiment runs.The characterization of the resulting catalyst shows that coating Ni-TiO₂ onto the modified SS has improved its photocatalytic properties.DRS and PL results showed not only well-doping TiO₂ by Ni but also coating Ni-TiO₂ onto the modified SS makes a reduction in the band gap, from 2.78 to 2.61 eV, and electron recombination.Addnl., the saturated magnetization value, VSM, for SS@Ni-TiO₂ was found to be 54 emu/g.The catalyst dosage was the most influent parameter which achieved an F-value of 42.18 followed by agitation time (33.58), pH (11.69) and concentration of permethrin (4.97) with the high R² value of 0.9952.Overall, the performance of the process in optimum conditions, such as pH 7, dose 0.7 g, concentration of permethrin 50 mgL^-1 and agitation time 30 min, was 72.11%, and the effect of the parameters studied on the process was significant (p-value <0.5).In addition, it resulted that plays a crucial role in the photocatalytic degradation of permethrin by SS@Ni-TiO₂ composite.The SS@Ni-TiO₂ exhibited excellent photocatalytic reactivity for permethrin over five cycles.During the five cycles, only 4% reduction was observed in the photocatalytic degradation of permethrin.In conclusion, the SS@Ni-TiO₂ would be a promising catalyst for photocatalytic degradation of permethrin from aqueous solution

2024-12-01·Molecular Biology Reports

Advancements in small interfering RNAs therapy for acute lymphoblastic leukemia: promising results and future perspectives

Review

作者: Heidari, Reza ; Rastgar, Amirhossein ; Kheyrandish, Setare ; Vahidi, Mahmoud ; Ghorbani, Mahdi

Acute lymphoblastic leukemia (ALL) is the most common type of cancer among children, presenting significant healthcare challenges for some patients, including drug resistance and the need for targeted therapies. SiRNA-based therapy is one potential solution, but problems can arise in administration and the need for a delivery system to protect siRNA during intravenous injection. Additionally, siRNA encounters instability and degradation in the reticuloendothelial system, off-target effects, and potential immune system stimulation. Despite these limitations, some promising results about siRNA therapy in ALL patients have been published in recent years, showing the potential for more effective and precise treatment, reduced side effects, and personalized approaches. While siRNA-based therapies demonstrate safety and efficacy, addressing the mentioned limitations is crucial for further optimization. Advancements in siRNA-delivery technologies and combination therapies hold promise to improve treatment effectiveness and overcome drug resistance. Ultimately, despite its challenges, siRNA therapy has the potential to revolutionize ALL treatments and improve patient outcomes.

100 项与 Aja University of Medical Sciences 相关的药物交易

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100 项与 Aja University of Medical Sciences 相关的转化医学

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