Standardized Corn-Soy Blend with Nutrition Education versus Nutrition Education Alone in Community-based Management of Children Under Five Years of Age with Moderate Acute Malnutrition: A Randomized Controlled Clinical Trial

开始日期2020-03-02

申办/合作机构

University of Uyo

100 项与 University of Uyo 相关的临床结果

登录后查看更多信息

0 项与 University of Uyo 相关的专利（医药）

登录后查看更多信息

4,021

项与 University of Uyo 相关的文献（医药）

2025-06-01·Waste Management

Cereal processing by-products and wastewater for sustainable protein extraction

Article

作者: Sharma, Nitya ; Tiwari, Brijesh K ; Pojić, Milica ; Esua, Okon Johnson ; Bhardwaj, Aastha

The global food supply chain faces significant challenge due to substantial losses and waste, particularly in cereal processing. This review focuses on sustainable protein extraction from wastewater and by-products of key cereals, including rice, wheat, corn, millet, and oats. The structural conformation, molecular weight distribution, amino acid content, and bioactive characteristics of the extracted proteins were examined, highlighting their potential applications in food and allied industries. Certain proteins, such as globulins (52 kDa) and lipid transfer proteins (9 kDa), contribute to the functional qualities of rice by-products, which show strong antioxidant capacity. Zein and gliadins, two proteins found in maize and wheat, have noteworthy bioactive qualities but are linked to issues with allergenicity and high cost associated to their purification and extraction. The protein landscape is further diversified by oats and millet, which have distinct nutritional profiles and compositions. To enhance protein recovery while addressing cost and allergenicity constraints, biorefinery techniques integrating enzyme-assisted extraction with natural deep eutectic solvents (NADES) are explored. These methods not only improve extraction efficiency but also enhance protein bioavailability while reducing dependence on conventional solvents making the process more cost-effective and environmentally sustainable. The integration of these techniques within biorefinery frameworks enables simultaneous recovery of proteins, bioactive compounds, other high-value fractions, while significantly reducing food wastes and supporting circular economy principles. This review highlights the potential of cereal by-products as sustainable protein sources while emphasizing the crucial role of biorefineries in transforming these by-products into high-value products, contributing to a more sustainable and efficient food system.

2025-04-10·Energy & Fuels

Decoupled Water Electrolysis at High Current Densities Using a Solution-Phase Redox Mediator

Article

作者: Symes, Mark D. ; Mbang Eze, Obeten ; Ertekin, Zeliha

The electrolysis of water using renewably generated power to give "green" hydrogen is a key enabler of the putative hydrogen economy. Conventional electrolysis systems are effective for hydrogen production when steady power inputs are available, but tend to handle intermittent or low-power inputs much less well, in particular because it becomes very difficult to ensure separation of the hydrogen and oxygen products under intermittent or low-power regimes. Decoupled electrolysis offers one potential solution to the problem of interfacing electrolyzers with intermittent and low-power inputs: by allowing the hydrogen and oxygen products of electrolysis to be produced in separate devices to each other, systems in which gas mixtures are inherently much less likely to form can be designed. However, in general, decoupled electrolysis systems operate at rather low current densities (up to a few hundred mA/cm²), which detracts somewhat from their suitability for applications. Herein, we constructed a flow system device for decoupled hydrogen production using a solution of the polyoxometalate silicotungstic acid as a liquid-phase decoupling agent. This mediator has been explored as a mediator for decoupled hydrogen evolution before, but in this work, we significantly expanded the range of current densities over which decoupling is demonstrated, from 50 mA/cm² up to 1.35 A/cm², the latter of which exceeds the current densities at which commercial alkaline electrolyzers operate and which begins to approach those achievable with proton exchange membrane electrolyzers. Essentially complete decoupling of the hydrogen and oxygen generation processes is achieved across this full range of current densities, suggesting that rapid oxygen production with coupled redox mediator reduction is possible without compromising on decoupling efficiency.

2025-04-01·Natural Product Communications

Glucosyl Xanthone, d-Idopyranoside, Fatty Acid and Isoprene Derivatives as New Anti-Malarial Compounds Targeting Plasmodium Falciparum Thymidine Monophosphate Kinase (PfTMPK)

作者: Eseyin, Olorunfemi ; Isienyi, Casmir ; Okoroiwu, Henshaw ; Joseph, Akaninyene ; Iwara, Praise ; Umoaffia, Nikita ; Asanga, Edet ; Edet, Tonia ; Ani, Deborah ; Akpan, Mfon ; Ufot, Usenobong ; Edet, Uwem ; Kolawole, Olamide ; Nkang, Ani ; Okokon, Jude ; Essang, Samuel ; Samuel, Goodnews ; Nelson, Promise

Background Chemotherapy is considered the best approach in the management of malaria pathogenesis symptomized with hyperparasitemia and oxidative stress because of free radicals’ production; however, a crucial step in the production of DNA is the reversible phosphorylation of dTMP to dTDP, which is catalyzed by Plasmodium falciparum thymidylate kinase. Ethnopharmacologically and scientifically, Mangifera indica is used in the treatment of malaria, thereby necessitating antiplasmodial and antioxidant screening of the plant extract, as well as its in silico profiling to unravel the pharmacological and docking potentials of its bioactive compounds against thymidylate kinase. Methods The collection of the Mangifera indica stem bark, extract preparation, in vivo antiplasmodial assay, in vitro antioxidant assay, retrieval of Plasmodium falciparum thymidylate kinase, and gas chromatography-mass spectrophotometry (GC-MS) were done using standard protocols. The SwissADME tool was used in the prediction of the physicochemical, drug-likeness, and pharmacokinetic properties, whereas molecular docking analysis was done with the MCULE tool. ResultsThe GC-MS profiling revealed mangiferin, d-idopyranoside, lauric acid, fatty acid, isoprene derivatives, etc; these compounds contributed immensely to the plant's antioxidant and antiplasmodial (87.71%) potentials. Also, the compounds (55.7%) successfully docked the active sites of thymidylate kinase; 72.1% and 57.4% revealed high rates of gastrointestinal tract (GIT) absorption and distribution in the interstitial tissues, respectively, whereas 98.4% were not substrates of permeation glycoprotein. However, the % non-inhibition of CYP1A2, CYP2C19, CYP2C9, CYP2D6, and CYP3A4 were 45.9, 98.4, 67.2, 95.1, and 98.4, respectively, while drug-likeness revealed 100% Lipinski's compliance.ConclusionThe observed antiplasmodial, antioxidant, and pharmacological properties could be due to the presence of the glucosyl xanthone, idopyranoside, fatty acid, and isoprene derivatives.

100 项与 University of Uyo 相关的药物交易

登录后查看更多信息

100 项与 University of Uyo 相关的转化医学

登录后查看更多信息