The effect of quercetin supplementation on antioxidant and inflammatory factors after the exhaustive progressive aerobic exercise in premenstrual syndrome in active young females

开始日期2024-11-10

申办/合作机构

Alzahra University

IRCT20211122053147N1

/ RecruitingN/AIIT

A Pilot Randomized Controlled Trial of an Online Hardiness Based Parenting Training Program for Parents of Children aged 10 to 12

开始日期2021-12-25

申办/合作机构

Alzahra University

NCT03946735

/ Unknown statusN/AIIT

Cognitive Behavioural Therapy as an Effective Treatment for Social Anxiety, Perfectionism, and Rumination

This randomized, controlled trial study was designed to examine the efficacy of Cognitive Behavioural Therapy (CBT) on social anxiety, perfectionism, and rumination among individuals diagnosed with social anxiety in Tehran, Iran.

开始日期2019-12-01

申办/合作机构

Alzahra University

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2025-12-01·Functional & Integrative Genomics

In silico analysis of betaine aldehyde dehydrogenase (BADH) gene in different cultivars of Chenopodium quinoa

Article

作者: Mirzaei, Ali Reza ; Salehi Sardoei, Ali ; Ghorbanpour, Mansour ; Fazeli-Nasab, Bahman ; Hatami, Mehrnaz

Chenopodium quinoa is an emerging halophyte plant that has gained significant attention from researchers in recent years due to its high nutritional value and resilience to environmental stress. This plant serves as an excellent substitute for rice and wheat. However, there has been limited research on it, leaving many of its genes still unidentified. The objective of this research was to identify gene patterns and conduct a bioinformatics analysis across various fields. The expression sequence of the betaine aldehyde dehydrogenase (BADH) gene was predicted using bioinformatics software such as PlantCARE and PlantPan. The findings indicated that different cultivars provide valuable information regarding resistance to the binding sites of MYB transcription factors, hormone response regions, and both promoter and enhancer regions, which contain 32 cis-regulatory elements. This emphasized the role of the BADH gene in responding to abiotic stress. Additionally, the research revealed that the BADH gene activates oxidoreductase activity across different cultivars, influencing NAD or NADP receptors that contribute to stress resistance. The protein lengths identified were 454 and 500 amino acids, respectively. Chloroplast analysis revealed that the GC content for the BADH gene was 37%. From this analysis, it was determined that out of 128 distinct functional genes in the genome, approximately 84 are protein-coding genes. An examination of the domains and motifs in the target genes showed that they contain two conserved sequences: Aldedh and DUF1487. Furthermore, miRNA analysis and promoter investigations indicated that the BADH gene plays a vital role in activating processes related to arginase, protein kinases, superoxide dismutase, tubulins, and membrane proteins. The gene is also crucial for activating nuclear transcription factors through receptor activation. In conclusion, the results suggest that BADH genes contribute to the plant's resistance to salt stress through various mechanisms. Stress acts as a trigger for the activation of this gene, effectively safeguarding the plant against the detrimental effects of environmental stresses.

2025-08-01·Journal of Molecular Structure

A novel Hg2+ ion chemosensor based on dihydro-pyrano imidazole derivatives

作者: Badiei, Alireza ; Panahande, Zahra ; Shamkhali, Nikoo ; Mohammadi Ziarani, Ghodsi

The synthesis of dihydro-pyrano imidazole derivatives through the novel multi-component reaction (MCRs) of p-benzaldehyde derivatives, malononitrile, and creatinine using SiO₂-Pr-SO₃H under solvent-free conditions has been developed.Using this approach results in a higher purity and yield while providing greener and more sustainable conditions.All obtained products were characterized and identified with FT-IR, ¹H NMR, ¹³C NMR, and Mass Spectroscopy anal.Furthermore, the photoluminescence properties of 2,5-Diamino-1-methyl-7-(4-nitro-phenyl)-1,7-dihydro-pyrano[2,3-d] imidazole-6-carbonitrile (10^-4 M) was investigated for the high sensitive and selective detecting of Hg²⁺ ions, which caused a remarkable quenching in fluorescence intensity using different metal cations without any interference including Na⁺, Mn²⁺, Ni²⁺, Cr³⁺, Zn²⁺, Pb²⁺, Al³⁺, Ag⁺, Cu²⁺, Mg²⁺, Hg²⁺, Cd²⁺, Co²⁺, K⁺ and Ca²⁺ in CH₃CN as a suitable solvent in the wavelength of excitation at 300 nm and the wavelength of emission at 460 nm with a detection limit of 11 x 10^-6 M.

2025-07-01·Journal of Molecular Structure

An overview of recent advances in enantioselective multicomponent reactions

作者: Mardi, Elham ; Shiri, Pezhman ; Rezvanian, Atieh

A review.Sequential transformations of three or more substrates in multicomponent reactions are known to yield architecturally intricate products.A vast majority of substrate components are transformed into the intended products with minimal generation of byproducts.The efficiency and variety of these reactions have led to their prominence in synthetic organic chem.Recently, the importance of enantioselective multicomponent processes has grown, especially in the domain of pharmaceutical and biol. mol. synthesis, due to the unique biol. properties displayed by enantiomers and diastereomers.The objective of the present review article is to provide an overview of the progress made in the enantioselective synthesis of compounds using multicomponent reactions, focusing on recent publications.

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