Randomized controlled trial on effect and risk of landmark method and ultrasonic guide method in stellate ganglion block - Randomized controlled trial of landmark method and ultrasonic guide method for stellate ganglion block

开始日期2019-11-08

申办/合作机构

Nippon Dental University School of Life Dentistry At Niigata

JPRN-UMIN000050616

/ CompletedN/AIIT

Effect of complementary therapies on the gag reflex: A randomized, placebo-controlled, double-blind, crossover study - Effect of complementary therapies on the gag reflex

开始日期2019-07-01

申办/合作机构

Nippon Dental University School of Life Dentistry At Niigata

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301

项与 Nippon Dental University School of Life Dentistry At Niigata 相关的文献（医药）

2025-04-01·Odontology

Maximum standardized uptake value for parotid and submandibular glands in patients with Sjögren’s syndrome and submandibular sialolithiasis using salivary gland SPECT/CT

Article

作者: Ogura, Ichiro ; Shirai, Ai

Recently, SPECT/CT plays an important role in assessing patients with head and neck lesions. The aim of this study was performed to investigate the maximum standardized uptake value (SUV_max) for parotid and submandibular glands in patients with Sjögren's syndrome and submandibular sialolithiasis using salivary gland SPECT/CT. A prospective study was performed in 45 patients with 32 Sjögren's syndrome and 13 submandibular sialolithiasis who underwent salivary gland SPECT/CT. The SUV_max of parotid and submandibular glands was obtained using a workstation and software. The salivary secretion function of parotid and submandibular glands was defined as ratio of pre- to post-stimulation on SUV_max. A p value lower than 0.05 was considered as statistically significant. The SUV_max for parotid glands in patients with Sjögren's syndrome at pre-stimulation (18.0 ± 14.3), post-stimulation (12.0 ± 9.4), and ratio of pre- to post-stimulation (1.46 ± 0.52) were significantly lower than those of submandibular sialolithiasis (44.9 ± 8.4 (p < 0.001), 17.8 ± 6.5 (p < 0.001), and 2.75 ± 0.79 (p < 0.001), respectively). The SUV_max for submandibular glands in patients with Sjögren's syndrome at pre-stimulation (16.9 ± 18.7) were significantly lower than those with sialolithiasis (36.7 ± 27.8, p = 0.004) and without sialolithiasis (39.7 ± 16.0, p = 0.001) in patients with submandibular sialolithiasis. The salivary gland SPECT/CT SUV_max can be useful in clinical practice for the quantitative management of parotid and submandibular glands in patients with Sjögren's syndrome and submandibular sialolithiasis.

2025-04-01·Modern Pathology

Cytoplasmic p53 Immunostaining in Salivary Duct Carcinoma: A Poor Prognostic Factor Associated With Characteristic TP53 Variants

Article

作者: Imanishi, Yorihisa ; Nagao, Toshitaka ; Utsumi, Yoshitaka ; Iwaki, Sho ; Hanazawa, Toyoyuki ; Nakaguro, Masato ; Sekimizu, Mariko ; Kohsaka, Shinji ; Sukeda, Aoi ; Shimizu, Akira ; Sato, Yuichiro ; Yamamura, Koji ; Fujii, Shota ; Imaizumi, Sae ; Hanyu, Kenji ; Hirai, Hideaki ; Honma, Yoshitaka ; Tada, Yuichiro ; Yamauchi, Mayu ; Kano, Satoshi ; Matsuki, Takashi ; Ueki, Yushi ; Tsukahara, Kiyoaki ; Saito, Yuki ; Takahashi, Hideaki ; Ozawa, Hiroyuki ; Yamazaki, Keisuke ; Kawakita, Daisuke ; Okami, Kenji ; Tanaka, Ryoko ; Arai, Tomoyuki

Salivary duct carcinoma (SDC) is an uncommon, high-grade malignancy. Identifying suitable prognostic factors is crucial for developing effective treatment strategies for SDC. p53 immunohistochemistry (IHC) is a potential prognostic marker for SDC. Traditionally, only the nuclear expression has been considered when evaluating aberrant p53 IHC patterns. However, recent studies on other organ cancers have highlighted the significance of the cytoplasmic p53 expression. We aimed to investigate the prognostic implications of cytoplasmic p53 positivity and its association with TP53 variants in a large cohort of patients with SDC. p53 IHC was performed in 327 SDC patients who had undergone primary curative resection. Based on the immunostaining patterns, patients were classified into four groups: wild-type (WT), overexpression (OE), complete absence (CA), and cytoplasmic (CY). Additionally, the TP53 gene status was analyzed in 239 cases by Sanger and/or next-generation sequencing. The p53 IHC patterns of 327 cases were as follows: WT (n = 125; 38.2%), OE (n = 100; 30.6%), CA (n = 75; 22.9%), and CY (n = 27; 8.3%). A TP53 genetic analysis of 239 cases revealed the following: wild-type status (n = 80; 33.5%), missense/inframe variants (n = 86; 36.0%), and truncating variants (n = 73; 30.5%). Notably, 24 of the 25 CY cases (96%) harbored TP53 variants, which were predominantly located in the domains responsible for nuclear translocation. Of these, 22 exhibited truncating variants. In a multivariate analysis, CY cases demonstrated significantly shorter disease-free survival (DFS) than WT cases (P = .01). Furthermore, patients with aberrant p53 expression patterns (OE+CA+CY) had significantly worse DFS and overall survival (OS) than those with WT (P = .003 and .002, respectively). The presence of TP53 variants was also associated with poorer DFS and OS (P = .003 and .02, respectively). Our findings suggest that the cytoplasmic expression of p53 in SDC represents a distinct aberrant pattern underlying characteristic genetic abnormalities and has significant prognostic implications.

2025-04-01·Clinical Anatomy

Evidence‐Based Anatomical Terminology in Dentistry Developed by a Consortium of Experts

Review

作者: Matsushita, Yuki ; Toriumi, Taku ; Samrid, Rarinthorn ; Kabak, Sergey L ; Hur, Mi-Sun ; He, Puhan ; Kitagawa, Norio ; Kim, Hee-Jin ; Hamada, Yusuke ; Wada, Junichiro ; Kikuta, Shogo ; Berkban, Thewarid ; Ibaragi, Soichiro ; Takeshita, Yohei ; Iwanaga, Joe

ABSTRACTThis article aimed to develop evidence‐based anatomical terminology in dentistry agreed upon by experts in multiple fields and ultimately to bridge anatomy and clinical dentistry. A comprehensive list of dental anatomical terminology was detailed in table format, and specific terms of interest were highlighted with their respective literature review. The presence of teeth is a unique feature of the oral cavity where dental professionals work. Dentistry is a highly specialized field focusing on preserving the health of dentition and its supporting and surrounding structures. Thus, “teeth” and “mouth” related anatomical terms must be very specialized for dentistry. Many of the terms highlighted were clinical dental or alveolar‐related terms that were not clearly established in the general anatomical terminology. The authors hope the evidence‐based anatomical terminology in dentistry developed by a consortium of experts will be generally accepted worldwide and ultimately bridge the fields of anatomy and clinical dentistry.

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