This project will first examine nature opportunities, belonging and benefits with a multi-state nature-based intervention with a focus on students of color. In light of the syndemic, 'nature deficit disorder' and poor mental health, the investigators anticipate several far-reaching impacts that will (a) test a nationally useful standardized way to quantify exposure; (b) invest in nature resources and accessibility on campuses; and (c) promote the mental health and therapeutic benefits of nature among young adults. These will lead to understanding the nature exposure and mental health interplay and techniques for quantifying and encouraging nature exposure to treat the on-going youth mental health crisis. Including HBCUs and an hispanic-serving institution is expected to result in heightened visibility of underlying disparities, including structural racism and land-based violence and discrimination, that have contributed to current-day nature gaps and dismantled nature relationships for students of color.

开始日期2024-09-09

申办/合作机构

Michigan State University

[+8]

NCT06519487 / Not yet recruitingN/AIIT

Perceived Discrimination, Geography, and Demographic Effects on Immune Cell Function and Regulation

Immune-mediated inflammatory diseases are a health burden for approximately seven percent of the population of Western nations. Preliminary data suggest variations in ethnic identity and/or geography influence discrimination experiences and inflammatory response trends. This study investigates how geography, ethnicity, and laboratory manipulation of discrimination experiences affect immune cell function and genomic regulation. Flow cytometry and immune cell stimulation will test monocytes collected from peripheral blood for functional effects. Next-generation transcriptomics and epigenomics will assess genomic and epigenetic mechanisms. The hypothesis is that geography, self-identified race, and ethnicity, interacting with laboratory discrimination conditions during the virtual ballgame Cyberball™, significantly affect immune cell function through genomic and epigenetic mechanisms, with perceived discrimination as a moderating factor on the immune outcomes. The transdisciplinary nature of the proposed study aims to provide valuable insights into differential susceptibility to immune-mediated inflammatory diseases across diverse populations. Uncovering these insights will better inform population-relevant interventions for immune-mediated inflammatory diseases.

开始日期2024-09-01

申办/合作机构

Morgan State University

[+3]

NCT06522685 / Not yet recruitingN/AIIT

Neural and Immune Correlates of Painful Chemotherapy-Induced Neuropathy, Feasibility and Preliminary Efficacy of a Motor Cortex Non-Invasive Brain Stimulation Intervention

Over half of cancer patients receiving common chemotherapy treatments experience painful nerve damage called chemotherapy-induced peripheral neuropathy (CIPN). Non-Hispanic Black (NHB) patients are more likely to suffer from this condition and more often need to reduce their chemotherapy doses compared to Non-Hispanic White (NHW) patients.
Currently, only one medication, duloxetine, is approved for treating CIPN, but it doesn't work for everyone. A new approach, transcranial direct current stimulation (tDCS), shows promise as a safe and effective treatment. tDCS can be done at home and reduces the need for hospital visits.
Research indicates that tDCS can improve pain responses in the brain's pain control network. There are differences in pain sensitivity and brain activity related to pain between NHB and NHW individuals, which may influence the effectiveness of treatments.
This research aims to conduct a study to:
1. Test if tDCS is a helpful treatment for painful CIPN.
2. Investigate how CIPN affects brain function in NHB and NHW patients.
3. Examine the role of inflammation in CIPN and its connection to pain severity and brain function.
The investigators expect that NHB patients will benefit more from tDCS due to differences in their brain's pain response system. This project aims to address health disparities and improve outcomes for urban communities, particularly in Baltimore.

开始日期2024-09-01

申办/合作机构

Morgan State University

[+1]

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0 项与 Morgan State University 相关的专利（医药）

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项与 Morgan State University 相关的文献（医药）

2024-12-31·Renal failure

Text mining of hypertension researches in the west Asia region: a 12-year trend analysis

Article

作者: Rajabi Kouchi, Faezeh ; Rezapour, Hassan ; Khorrami, Zahra ; Khavanin Zadeh, Morteza ; Habibi Baghi, Masoomeh ; Pourbaghi, Elmira ; Yazdinejad, Mohsen ; Rezapour, Mohammad

More than half of the world population lives in Asia and hypertension (HTN) is the most prevalent risk factor found in Asia. There are numerous articles published about HTN in Eastern Mediterranean Region (EMRO) and artificial intelligence (AI) methods can analyze articles and extract top trends in each country. Present analysis uses Latent Dirichlet allocation (LDA) as an algorithm of topic modeling (TM) in text mining, to obtain subjective topic-word distribution from the 2790 studies over the EMRO. The period of checked studied is last 12 years and results of LDA analyses show that HTN researches published in EMRO discuss on changes in BP and the factors affecting it. Among the countries in the region, most of these articles are related to I.R Iran and Egypt, which have an increasing trend from 2017 to 2018 and reached the highest level in 2021. Meanwhile, Iraq and Lebanon have been conducting research since 2010. The EMRO word cloud illustrates 'BMI', 'mortality', 'age', and 'meal', which represent important indicators, dangerous outcomes of high BP, and gender of HTN patients in EMRO, respectively.

2024-11-01·ACCIDENT ANALYSIS AND PREVENTION

Developing equity-aware safety performance functions for identifying hotspots of pedestrian-involved crashes

Article

作者: Yang, Hong ; Yang, Di ; Xie, Kun ; Zhai, Guocong

Crashes are frequently disproportionally observed in disadvantaged areas. Despite the evident disparities in transportation safety, there has been limited exploration of quantitative approaches to incorporating equity considerations into road safety management. This study proposes a novel concept of equity-aware safety performance functions (SPFs), enabling a distinct treatment of equity-related variables such as race and income. Equity-aware SPFs introduce a fairness distance and integrate it into the log-likelihood function of the negative binomial regression as a form of partial lasso regularization. A parameter λ is used to control the importance of the regularization term. Equity-aware SPFs are developed for pedestrian-involved crashes at the census tract level in Virginia, USA, and then employed to compute the potential for safety improvement (PSI), a prevalent metric used in hotspot identification. Results show that equity-aware SPFs can diminish the effects of equity-related variables, including poverty ratio, black ratio, Asian ratio, and the ratio of households without vehicles, on the expected crash frequencies, generating higher PSIs for disadvantaged areas. Based on the results of Wilcoxon signed-rank tests, it is evident that there are significant differences in the rankings of PSIs when equity awareness is considered, especially for disadvantaged areas. This study adds to the literature a new quantitative approach to harmonize equity and effectiveness considerations, empowering more equitable decision-making in safety management, such as allocating resources for safety enhancement.

2024-10-09·ACS Applied Materials & Interfaces

Strongly Interacting Nanoferrites for Magnetic Particle Imaging and Spatially Resolved Thermometry

Article

作者: Merritt, Mia T. ; Seppala, Jonathan E. ; Biacchi, Adam J. ; Hight Walker, Angela R. ; Donahue, Michael J. ; Abel, Frank M. ; Dennis, Cindi L. ; Correa, Eduardo L. ; Bui, Thinh Q. ; Woods, Solomon I.

High-crystal-quality nanoferrites with short surface ligands (oleic acid) were recently shown to exhibit enhanced sensitivity and spatial resolution, likely due to chain formation (uniaxial assemblies of particles) for magnetic particle imaging (MPI). Here, we develop a simple one-pot thermal decomposition approach to produce ferrite (iron oxide) magnetic nano-objects (MNOs) that strongly interact magnetically and have good synthetic reproducibility. The ferrite MNOs were physically characterized by X-ray diffraction, Raman spectroscopy, transmission electron microscopy, and dynamic light scattering. The MNOs were magnetically characterized by magnetometry and magnetic particle spectroscopy (MPS) to study their interactions, dynamics, and suitability for spatially resolved magnetic thermometry. The MNOs were synthesized in a range of sizes between 12 nm and 27 nm, showing that MNOs below a minimum size do not exhibit dynamic interactions/significant increased response and that a larger field is required for chain formation as size increases. In addition to size effects, we explore the role of ligand length, environment (liquid vs solid), and concentration on the proposed chain formation. The experimental results were then correlated to micromagnetic simulations to gain further insight into the formation of chains. Compared to some existing MPI tracers, our ferrite MNOs exhibit enhanced signal (up to about 37×) and spatial resolution (up to about 9×) under certain limited (ferrite-MNO optimal) field and frequency conditions used. MPS as a function of temperature and drive field amplitude was performed, showing promise for spatially resolved thermometry. These results confirm the importance of tuning the frequency and amplitude of the drive field for optimal imaging/thermal performance.

项与 Morgan State University 相关的新闻（医药）

2024-10-31

·PRNewswire

Uwill Wins Best Mental Health Technology

Merit Awards recognize mental health leader with top honors in healthcare category for its impact on student mental health NATICK, Mass., Oct. 31, 2024 /PRNewswire/ -- Uwill, the leading mental health and wellness solution for colleges and students, was honored as the 2024 Merit Awards for Healthcare 'Gold' winner for 'Best Mental Health Technology'. "The 2024 Healthcare winners represent the absolute best in healthcare innovation," said Marie Zander, Executive Director of the Merit Awards. "These pioneers are setting a high bar for the future of healthcare, and we are honored to recognize their exceptional contributions." The Merit Awards Healthcare program honors organizations that have made significant contributions to healthcare across a range of categories. The winners were selected by a distinguished panel of industry experts for their remarkable achievements in improving healthcare delivery and innovation. "Our team is honored to receive this award, which underscores our commitment to offering immediate mental health and wellness support, eliminating all barriers to care," said Michael London, Founder and CEO of Uwill. "We're dedicated to meeting the mental health needs of all students. This award reflects the positive impact our technology and our counselor community have made on campuses nationwide." Utilizing its proprietary technology and counselor team, Uwill pioneered the first student and therapist matching platform. The solution offers an immediate appointment with a licensed counselor based on student preferences, all modalities of teletherapy, a direct crisis connection, wellness events, realtime data, and support. Uwill serves more than 3 million students from all 50 states at institutions including Rutgers University, the Alabama Community College System, Morgan State University, and University of California, Santa Barbara. About Uwill: Uwill is the leading mental health and wellness solution for colleges and students, and the 27th fastest growing private company in the nation. As the most cost-effective way to enhance a college's mental health offering, Uwill partners with more than 400 institutions, including Princeton University, the Ohio State University, Santa Fe Community College, and University of Alabama - Online. Uwill is also the exclusive teletherapy education partner for the Online Learning Consortium and teletherapy education partner of NASPA. For more information, visit uwill.com. Contact: Brett Silk [email protected] SOURCE Uwill, Inc WANT YOUR COMPANY'S NEWS FEATURED ON PRNEWSWIRE.COM? 440k+ Newsrooms & Influencers 9k+ Digital Media Outlets 270k+ Journalists Opted In GET STARTED

2024-09-01

·约翰霍普金斯医院

如何饮食更能保护大脑健康？约翰·霍普金斯大学最新研究

“ 点击上方图标关注我们原稿来源：约翰·霍普金斯大学医疗新闻网饮食对大脑健康的影响图片来源：Getty Images 约翰·霍普金斯大学医学院和美国国立卫生研究院（NIH）国家老龄问题研究所的研究对40名患有肥胖症和胰岛素抵抗的老年人进行了追踪，这些老年人被随机分配到间歇性禁食饮食计划组或美国农业部（USDA）批准的标准健康饮食计划组中，这项研究探索了这两种饮食计划对大脑健康的潜在益处，并提供了重要线索。胰岛素抵抗是2型糖尿病的标志，在肥胖人群中很常见。研究表明，胰岛素抵抗患者罹患阿尔茨海默病和其他认知障碍的风险比健康人更高。因此，各类（饮食）减肥方案通常被认为是降低这些新陈代谢和脑部疾病风险的有效方法。约翰·霍普金斯大学对糖尿病和阿尔茨海默病动物模型的研究表明，间歇性禁食可以改善认知能力和胰岛素敏感性。发表在6月19日的《细胞新陈代谢》（Cell Metabolism）杂志上的新研究测试了间歇性禁食对有认知障碍风险的女性和男性的影响，作者指出，这项研究提供了一个 “蓝图”，即利用广泛的生物标志物来评估饮食的影响，包括分析细胞外囊泡--神经元（一种发送信息的脑细胞）脱落的微小物质包。这种神经元产生的细胞外囊泡会脱落到循环血液中，在为期八周的新研究中，我们收集了参与者在一种（两种饮食中选择一种）饮食习惯下的细胞外囊泡。约翰·霍普金斯大学医学院神经科学兼职教授、国家老龄化研究所神经科学实验室（位于巴尔的摩）前主任 Mark Mattson 博士说：“研究结果表明，这两种饮食计划对降低胰岛素抵抗和改善认知能力都有好处，两种饮食都能改善记忆力和执行功能，但间歇性禁食饮食的改善效果更明显。其他科学家可能希望将（我们使用的）大脑标记纳入更多更大规模的饮食和大脑健康研究中。” 由于肥胖和胰岛素抵抗的人可能比代谢和体重指数（BMI）正常的人更容易患认知障碍和阿尔茨海默病，美国国立老龄化研究所人类神经科学组组长、约翰·霍普金斯大学医学院神经病学兼职副教授 Dimitrios Kapogiannis 医学博士开发了一种从血液中分离神经元衍生细胞外囊泡的方法。他的实验室在糖尿病患者和阿尔茨海默病患者神经元脱落的细胞外囊泡中，发现了胰岛素抵抗的分子证据，由于血液样本相对容易收集，因此被认为是广泛使用的良好候选样本。 Mark Mattson, PhD JHU 医学院神经科学兼职教授国家老龄化研究所神经科学实验室前主任 Dimitrios Kapogiannis, M.D. JHU 医学院神经病学兼职副教授国立老龄化研究所人类神经科学组组长为了测试这两种饮食对大脑功能生物标志物的影响，新研究在2015年6月至 2022年12月期间，招募了参与者，并在巴尔的摩 MedStar Harbor 医院国家老龄化研究所管理的设施中，完成了四次面对面的评估。参与者中有40人完成了为期八周的研究。其中，有20人被分配到间歇性禁食饮食组中，每周连续两天将卡路里限制在建议日摄入量的四分之一，其余五天则遵循美国农业部的健康生活饮食标准，包括水果、蔬菜、全谷物、瘦肉、低脂乳制品以及限量添加的糖、饱和脂肪和钠。其余的20人被分配到美国农业部的标准健康生活饮食组中，每周每天给予标准的饮食计划。两组参与者的平均年龄为63岁，25人为白人，14人为黑人，1人为西班牙裔。其中，男性24人，女性16人。所有人都患有肥胖症和胰岛素抵抗。研究人员发现，这两种饮食对减少细胞外囊泡中的胰岛素抵抗标志物、改善大脑年龄（利用核磁共振成像结构数据测量大脑的生物年龄）和降低大脑中的葡萄糖浓度都有同样积极的作用。葡萄糖浓度降低是葡萄糖利用率提高的必然结果。这两种饮食还改善了代谢健康的常规测量，包括体重、体重指数、腰围、血脂（如胆固醇）和胰岛素抵抗。与健康生活饮食组相比，间歇性禁食组的执行功能和记忆力（这是一套有助于规划和实现目标的心理技能）提高了约20%。少数研究参与者报告了轻微的副作用，包括便秘、大便稀烂和偶发的头痛。研究人员还发现，两组饮食中的神经丝蛋白（神经元中的一种结构蛋白）水平都有所提高，但主要存在于间歇性禁食组。这对大脑健康意味着什么？答案尚不清楚。 Mattson 博士说：“这个标记需要在进一步研究中被继续评估。神经元会释放大量蛋白质，一种观点认为，间歇性禁食可能会引起神经元的某种神经可塑性（结构变化），导致神经丝蛋白的释放。” 研究人员提醒说：“对间歇性禁食感兴趣的人应该与健康专家一起认真地计划，因为它可能对某些人有害，包括那些患有1型糖尿病和饮食紊乱的人。” 该研究的相关奖项、支持和合作人员《细胞代谢》杂志报道的研究获得了美国国立卫生研究院国家老龄化研究所（ZIAAG000966、ZIAAG000975）的支持。为这项研究做出贡献的其他研究人员还包括：来自美国国立老龄化研究所的 Apostolos Manolopoulos、Francheska Delgado-Peraza、Maja Mustapic、Carlos Nogueras-Ortiz、Pamela Yao、Krishna Pucha、Janet Brooks、Qinghua Chen、Lisa Hartnell、Mark Cookson 和 Josephine Egan，来自摩根州立大学的 Roger Mullins，来自韦恩州立大学的 Konstantinos Avgerinos，来自西奈山医学院的 Shalaila Haas 和 Sophia Frangou 以及来自不列颠哥伦比亚大学的 Ruiyang Ge。免责声明：此信息仅用于科普目的，不能代替医疗意见。本文由约翰·霍普金斯彭博公共卫生学院发布，未经允许，不得转载。翻译与编辑：Lin Zhang 资料来源：https://publichealth.jhu.edu/ 关于我们原文来源：彭博公共卫生学院 JHSPH 官方微信公众号长按二维码关注我们

2024-08-13

·PRNewswire

TEDCO's Maryland Innovation Initiative (MII) Announces Recent Investments

$2.1M invested in seven companies to advance innovations from lab to market in Maryland COLUMBIA, Md., Aug. 13, 2024 /PRNewswire/ -- TEDCO, Maryland's economic engine for technology companies, announced a recent round of investments through its Maryland Innovation Initiative (MII), marking a significant milestone in promoting the commercialization of groundbreaking research from Maryland's prestigious academic institutions. Continue Reading $2.1M invested in seven companies to advance innovations from lab to market in Maryland Post this Genetic research and Biotech science Concept. Human Biology and pharmaceutical technology on laboratory background. Maryland Innovation Initiative logo (PRNewsfoto/TEDCO) "The latest awards highlight the innovative research in university labs with tremendous commercial potential across multiple industries," said Abi Kulshreshtha, Ph.D., executive director, MII. "We are excited to continue MII's role in advancing Maryland's innovation-driven economic development strategy." The fund recently invested $2.1 million into seven companies who are pushing the boundaries of innovation: Gelectric Medical, Inc., located in Baltimore, Md., is a University of Maryland, College Park (UMCP) spinout commercializing a reversible soft-tissue suture alternative for intestinal tissue repair: AnastoTape. Imagining Reality Insights and Solutions, located in Baltimore, Md., is a UMCP spinout commercializing IRIS Reads, an XR based reading intervention app for children with dyslexia and other struggling readers. Reversal Therapeutics, located in National Harbor, Md., is a UMCP spinout commercializing a new therapeutic to address drug misuse and addiction. FlexiCharge: Harnessing Human Energy to Power Wearable Devices, located in Ellicott City, Md., is a University of Maryland, Baltimore County spinout developing technology to power wearable devices with body heat. US Plasma, located in College Park, Md., is a UMCP spinout that is working to electrify manufacturing and synthesis of new materials with minimal to negative carbon emission. Relai.ai, located in Bethesda, Md., is a UMCP spinout that enhances the reliability of AI models. New Copper, located in College Park, Md., is a UMCP spinout enabling 3D printed electronics through a conducting technology using recycled copper. Start-up companies joining TEDCO's MII portfolio have access to a variety of TEDCO resources including mentor opportunities and CEO roundtables to loaned executives. A complete list of funded companies can be found on the MII website. MII's Funding Opportunities The MII program, administered by TEDCO (the Maryland Technology Development Corporation), was created as a collaboration between the State of Maryland and five leading academic research institutions—Johns Hopkins University, Morgan State University, University of Maryland, Baltimore, University of Maryland, Baltimore County, and University of Maryland, College Park— that aims to leverage each institution's strengths to transition promising technologies into the commercial sector. "We are excited to see the research and development taking place in our university laboratories," said Renée Winsky, MII board chair. "These seven investments highlight the diverse array of innovative minds we have in Maryland's university laboratories, and we are committed to supporting their continued growth. With the appointment of Abi as the MII executive director, we are confident that this initiative will continue driving innovation from the lab to the commercial market." In addition to investments, MII provides grant opportunities, through two phases of awards: Technology Assessment and Company Formation. The Technology Assessment phase is outlined as a nine-month project that focuses on technology validation and market assessment, while the Company Formation phase supports the commercial launch of technologies. This structure is designed to support the full commercialization journey, from lab to market. These two phases recently underwent changes to enhance the current support MII offers. Since inception, MII has expanded its reach to include two additional comprehensive universities, Frostburg State University and Bowie State University, as part of the MII Pilot Programs. This initiative aims to foster innovation and bring more research to the market. To view MII's 2023 Annual Report, click here, and for more information about the MII program, eligibility requirements and funding available, visit . About TEDCO TEDCO, the Maryland Technology Development Corporation, enhances economic empowerment growth through the fostering of an inclusive entrepreneurial innovation ecosystem. TEDCO identifies, invests in, and helps grow technology and life science-based companies in Maryland. Learn more at . Media Contact Tammi Thomas, Chief Development & Marketing Officer, TEDCO, [email protected] SOURCE TEDCO