In several studies comparing the tow types of pancreato-digestive anastomosis: pancreatogastrostomy (PG) and pancreatojejunostomy (PJ), authors concluded that PG exposed to more postpancreatectomy hemorrhage (PPH) especially early, digestive and moderate hemorrhage classified as type A according to the classification of the ISGPS.
In this way we try to test the ability of the enteral administration through the nasogastric tube of Etamsylate for 48 hours after Whipple to reduce the rate of digestive PPH and mortality.

开始日期2024-01-01

申办/合作机构

Université de Sfax

NCT06444672 / CompletedN/AIIT

Effects of a Home-Based Rehabilitation on Anthropometric Measures, Sensory-Motor Functions and Independence After Spinal Cord Injury

Background: The scarcity of resources for spinal cord injury (SCI) rehabilitation constitutes a significant obstacle, particularly in war-torn regions experiencing a rise in such injuries. Implementing a home-based rehabilitative program (HBRP) tailored to patients' environmental, social, and financial contexts is crucial in mitigating this challenge. The authors investigated the effects of a 24-month HBRP on anthropometric measurements, muscular strength, sensory and motor function, and independence in participants transitioning from bed to walking following SCI.
Methods: Serial case study in a quasi-experimental design, the conducting was at the participants' homes. The participants were four patients with SCI (experimental group) and another two patients with SCI (control group). The interventions were a 24-month HBRP comprising strength, flexibility, and balance training, the outcome measures involved anthropometric measurements, muscle strength using a digital handheld dynamometer, muscle thickness, and cross-sectional area measured using magnetic resonance imaging, measured five walking tests, and the American Spinal Injury Association scale (ASIA) score for assess the sensory and motor score, and the Spinal Cord Independence Measure (SCIM).

开始日期2021-09-25

申办/合作机构

University of Mosul

[+1]

NCT06486935 / RecruitingN/AIIT

City For All Ages: Elderly-friendly City Services for Active and Healthy Ageing

Many city-dwelling elderly people can be greatly affected after a minor change in their living or health conditions. Mild Cognitive Impairment (MCI), early dementia and frailty are among the most common risks with deep consequences on elderly's and caregivers' quality of life. Through the new wave of Information and Communication Technologies (ICT), Internet of Things (IoT) and smart city system, it is now possible to help individuals capture and make use of their personal data in a way that will help them maintain their independence for longer. The City for all Ages project will create an innovative service based on:
* ICT-enhanced early detection of risk related to frailty
* ICT-enhanced interventions that can help the elderly population to improve their daily life and also promote positive behaviour change
Through real-life pilot sites in Singapore in collaboration with TOUCH Senior Activity Centre (SAC) and the Housing Development Board (HDB), this project explores how data on individual behaviours captured through indoor and outdoor sensors could be used for the observation and detection of the following parameters:
* Activity of Daily Living (ADL): nutrition, hygiene, sleep activity
* Mobility: physical activity, going-out frequency and length
* Cognition: forgetfulness, early signs of mental decline
* Socialization: senior activity centre visits, activities attended, other places of interests visits
This 2-year project comprises of 3 phrases involving 10 healthy elderly living in HDB home in phases 1 and 2 and 100 elderly in phase 3. Our focus is to use sensing technologies installed in the elderly's home to monitor and detect their activities of daily living. Sensor data that is collected will then be analyzed to identify relevant behaviours of individuals, and to detect behavioral changes that can be correlated with risks of MCI/frailty. The appropriate ICT based interventions (e.g. data visualization and alerts to caregivers) will then be applied to mitigate these risks. Additionally, psychosocial data related to the elderly's quality of life, social activity participation and activities of daily living will also be collected via interviews and activity logs to evaluate the outcomes of our technology intervention.

开始日期2016-01-30

申办/合作机构

National University of Singapore

[+1]

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7,133

项与 Université de Sfax 相关的文献（医药）

2025-02-01·FUEL

Sustainable biodiesel production from Ficus nitida leaves through the in-situ bioconversion of membrane galactolipids by Talaromyces thermophilus galactolipase

作者: Jlassi, Hela ; Abdelkader, Ines ; Parsiegla, Goetz ; Launay, Helene ; Carriere, Frederic ; Jlaiel, Lobna ; Gargouri, Ali ; Belhaj, Ines ; Belghith, Hafedh

Galactolipids constituting the chloroplast membranes in photosynthetic organisms represent the main reservoir of fatty acids on earth.This abundant resource is, however, completely untapped.Galactolipids are not accessible by simple phys. means as vegetable triacylglycerols since they are dispersed in plant biomass.Here, we establish that Talaromyces thermophilus lipase (TTL), with a high galactolipase activity, has the capacity to hydrolyze and fully convert the natural galactolipids of dried Ficus nitida leaves as a non-oilseed green feedstock to produce fatty acids (FA) and fatty Me esters (FAME), resp.Its high galactolipase activity was further explored by performing in-situ transesterification reaction on the whole green biomass.Thus, a successful system for one-pot procedure was developed.Optimized methanolysis conditions were obtained with a lipid/methanol molar ratio of 1/6, chloroform as a co-solvent, a temperature of 37 °C and 660 U of free TTL for 750 mg of dried F. nitida leaves pretreated with glycosyl hydrolases.After 12 h of reaction, 121 ± 8.2 mg of biodiesel was obtained, of which 66 % was composed of FAME(s) and 33 % was composed of alkanes (C16-C24). 80 ± 1.14 mg of FAME(s) were converted from galactolipid FA within leaves with a recovery yield of 89 %.The methanolic extract of F. nitida leaves was evaluated as an antioxidant source and could help prevent the oxidation process of the polyunsaturated FAME(s) produced.Lastly, recovering and/or converting galactolipid FA in green biomass shows promise as a way of producing mols. with a potential to co-refine in existing petroleum refineries and to avoid competing interests with vegetable oils.

2025-02-01·JOURNAL OF MOLECULAR STRUCTURE

New lead-freeIodoantimonatehalide semiconductor: Synthesis, Structural characterization, DFT calculations, Hirshfeld surface, Thermal behavior, vibrational and optical properties

作者: Shova, Sergiu ; Boujelbene, Mohamed ; Jridi, Chaima ; Elleuch, Nour

Hybrid metal halides have captured broad interest in the lighting and display fields because of their unique electronic structures and splendid broadband emission properties.Organic chiral building blocks can control light, charge, and spin interconversion in hybrid crystalline semiconductors with metal-halide.Based on the chiral organic mols.(S)-1-phenylethylamine, we synthesized new chiral antimony halidewith zero-dimensional structure((S)-C₈H₁₂N)₄Sb₂I₁₀.Atroom temperature, the title compound is crystallized in the monoclinic P21with Z = 2 and the following unit cell dimensions: a = 12.69129 (15) Å, b = 14.96770 (15) Å, c = 13.91397 (16) Å, and β = 92.2735 (11)°.The crystal structure of this compound is composed of two crystallog. independent [Sb₂I₁₀]^4- unit and four (S)-1-phenylethylammonium per unit cell.The crystal packing is governed by N-H....I hydrogen bonds.Intermol. interactions seen in the grown single crystal are studied by Hirshfeld surface and 2-D fingerprint plot.In addition to study the weak interaction a visualized approach known as RDG has been carried out.The recorded IR IR and Raman studies confirm vibrational modes for organic and inorganic groups at room temperature in the 500-4000 cm^-1 and 50-4000 cm^-1 frequency regions, resp.The optimized mol. structure and vibrational frequencies were calculated by the D. Functional Theory (DFT) method using the B3LYP level employing a LANL2DZbasis set.The title compound reveals thermal stability up to 190 °C.The opticalabsorption measurement confirms the semiconductor nature with a band gap of around 3.74 eV.The frontier MO anal. HOMO-LUMOof mol. were studied.

2025-01-01·GENE

Gardner syndrome in a Tunisian family: Identification of a rare APC mutation through targeted NGS

Article

作者: Ameur, Hazem Ben ; Gargouri, Raja Mokdad ; Boujelbene, Salah ; Guidara, Souhir ; Gdoura, Hela ; Tahri, Nabil ; Barkia, Baha ; Abdelmaksoud-Dammak, Rania ; Kamoun, Hassen ; Ammous-Boukhris, Nihel ; Boudabbous, Mouna

Gardner syndrome (GS) is a subtype of familial adenomatous polyposis (FAP) characterized by colorectal polyps, multiple osteomas, soft tissue tumors, and specific oral manifestations, such as jaw osteomas. GS is caused by mutations in the APC gene, resulting in a nonfunctional protein. This study reports a comprehensive clinical evaluation and genetic analysis of a Tunisian family affected by GS. Targeted exome sequencing and Sanger sequencing techniques were employed to identify and validate mutations in the APC gene. Clinical observations of the patient revealed multiple sebaceous cysts, frontal and maxillary osteomas, and several gastrointestinal polyps. Genetic analysis revealed a pathogenic variant (c.4652-4655del) in the APC gene, leading to a truncated protein. Additionally, genetic testing of the patient's child indicated that the child does not carry the APC pathogenic variant. In conclusion, our study highlights the importance of genetic testing in raising awareness of GS among clinicians to ensure early diagnosis and effective management, thereby reducing the risk of development and progression of colorectal cancer.

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