Delving into the Latest Updates on New England Discovery Partners LLC with Synapse

概览

关联

1

项与 New England Discovery Partners LLC 相关的药物

NED-3238

靶点

ARG1 x ARG2

作用机制

ARG1抑制剂 [+1]

在研机构-

原研机构

New England Discovery Partners LLC

在研适应症-

非在研适应症-

最高研发阶段无进展

首次获批国家/地区-

首次获批日期-

100 项与 New England Discovery Partners LLC 相关的临床结果

登录后查看更多信息

0 项与 New England Discovery Partners LLC 相关的专利（医药）

登录后查看更多信息

6

项与 New England Discovery Partners LLC 相关的文献（医药）

2018-12-01·Nature Chemical Biology1区 · 生物学

Small molecules that target group II introns are potent antifungal agents

1区 · 生物学

Article

作者: Jagdmann, G Erik ; Pyle, Anna Marie ; Yuan, Lin ; Fedorova, Olga ; Adams, Rebecca L ; Van Zandt, Michael C

Specific RNA structures control numerous metabolic processes that impact human health, and yet efforts to target RNA structures de novo have been limited. In eukaryotes, the self-splicing group II intron is a mitochondrial RNA tertiary structure that is absent in vertebrates but essential for respiration in plants, fungi and yeast. Here we show that this RNA can be targeted through a process of high-throughput in vitro screening, SAR and lead optimization, resulting in high-affinity compounds that specifically inhibit group IIB intron splicing in vitro and in vivo and lack toxicity in human cells. The compounds are potent growth inhibitors of the pathogen Candida parapsilosis, displaying antifungal activity comparable to that of amphotericin B. These studies demonstrate that RNA tertiary structures can be successfully targeted de novo, resulting in pharmacologically valuable compounds.

2018-10-01·Cell Chemical Biology1区 · 生物学

Editing N-Glycan Site Occupancy with Small-Molecule Oligosaccharyltransferase Inhibitors

1区 · 生物学

Article

作者: Marceau, Caleb D ; Gilmore, Reid ; Contessa, Joseph N ; Golden, Jennifer E ; Rinis, Natalia ; Carette, Jan E ; Van Zandt, Michael C

The oligosaccharyltransferase (OST) is a multisubunit enzyme complex that N-glycosylates proteins in the secretory pathway and is considered to be constitutive and unregulated. However, small-molecule OST inhibitors such as NGI-1 provide a pharmacological approach for regulating N-linked glycosylation. Herein we design cell models with knockout of each OST catalytic subunit (STT3A or STT3B) to screen the activity of NGI-1 and its analogs. We show that NGI-1 targets the function of both STT3A and STT3B and use structure-activity relationships to guide synthesis of catalytic subunit-specific inhibitors. Using this approach, pharmacophores that increase STT3B selectivity are characterized and an STT3B-specific inhibitor is identified. This inhibitor has discrete biological effects on endogenous STT3B target proteins such as COX2 but does not activate the cellular unfolded protein response. Together this work demonstrates that subsets of glycoproteins can be regulated through pharmacologic inhibition of N-linked glycosylation.

2015-04-01·Patient Education and Counseling3区 · 医学

Identifying and intervening on barriers to healthcare access among members of a small Korean community in the southern USA

3区 · 医学

Article

作者: Song, Eunyoung ; Choi, Seungyong ; Choi, Sarah J ; Rhodes, Scott D ; Nam, Sang

OBJECTIVEWe used community-based participatory research (CBPR) to explore barriers to healthcare access and utilization and identify potentially effective intervention strategies to increase access among members of the Korean community in North Carolina (NC).METHODSOur CBPR partnership conducted 8 focus groups with 63 adult Korean immigrants in northwest NC and 15 individual in-depth interviews and conducted an empowerment-based community forum.RESULTSWe identified 20 themes that we organized into four domains, including practical barriers to health care, negative perceptions about care, contingencies for care, and provider misconceptions about local needs. Forum attendees identified four strategies to improve Korean community health.CONCLUSIONDespite the implementation of the Patient Protection and Affordable Care Act (ACA), many Korean community members will continue to remain uninsured, and among those who obtain insurance, many barriers will remain. It is imperative to ensure the health of this highly neglected and vulnerable community.PRACTICE IMPLICATIONSPotential strategies include the development of (1) low-literacy materials to educate members of the Korean community about how to access healthcare services, (2) lay health advisor programs to support navigation of service access and utilization, (3) church-based programming, and (4) provider education to reduce misconceptions about Korean community needs.

100 项与 New England Discovery Partners LLC 相关的药物交易

登录后查看更多信息

100 项与 New England Discovery Partners LLC 相关的转化医学

登录后查看更多信息