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LM-13765

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L. M. College of Pharmacy

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100 项与 L. M. College of Pharmacy 相关的临床结果

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0 项与 L. M. College of Pharmacy 相关的专利（医药）

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项与 L. M. College of Pharmacy 相关的文献（医药）

2025-12-01·Molecular Biology Reports

Retraction Note: The scaffold protein disabled 2 (DAB2) and its role in tumor development and progression

Article

作者: Jani, Maharsh A ; Gena, Ruhanahmed M ; Shah, Palak A ; Pandya, Disha V ; Chorawala, Mehul R ; Yadav, Mayur R ; Parekh, Priyajeet S ; Parikh, Rajsi V ; Kothari, Nirjari R

2025-06-01·Current Drug Discovery Technologies

Novel Targets for the Development of Tuberculosis Vaccine

Article

作者: Beladiya, Jayesh ; Solanki, Nilay ; Sheth, Devang ; Patel, Chirag ; Dalal, Mittal ; Joshi, Rushika ; Patel, Sandip B. ; Kyada, Ashish

In underdeveloped nations, tuberculosis (TB) continues to be a major source of morbidity and mortality. The currently available vaccine against tuberculosis in endemic areas is mainly ineffective, which triggers the need for a clinically effective vaccine against tuberculosis. In the present review, we emphasized the impact of genetic variations in the BCG strains, which influence the efficacy of BCG vaccines. We also discussed the current status of BCG vaccines and their potential mechanisms on the modulation of B cells and, thereby, humoral immunity, which trigger immune responses against various intracellular pathogens. Further, we also elaborated upon the pre-clinical and clinical studies demonstrating the efficacy and safety of the vaccines. Moreover, we also presented the putative novel targets such as polysaccharide-induced antibodies for the protection against Mtb, PGRS domain as an important target for Humoral immunity, HLA-E pathway-Target strategy for new TB vaccine, Coronin-1a - Novel player for Mycobacterial survival, IRGM, IFN-I3, an autophagy inducer with Irgm1 serving as a core part in the Tuberculosis vaccine development.

2025-05-01·International Journal of Biological Macromolecules

Apolipoprotein E3 functionalized mesoporous silica nanoparticles for targeted and enhanced therapeutic efficacy of Levetiracetam in brain tumor-associated epilepsy: Insights into brain uptake, biodistribution and pharmacokinetic behavior

Article

作者: Patel, Rashmin ; Athalye, Mansi ; Patel, Sandip ; Sharma, Abhilasha ; Chorawala, Mehul ; Patel, Mrunali

Epilepsy affects approximately 20-40 % of patients with brain-tumors, significantly impacting their quality of life and overall survival rates. To address this, Levetiracetam (LVM) has emerged as effective treatment option due to minimal negative interactions with other medications and reduced side-effects. However, its hydrophilic nature necessitates high doses and frequent administration, which can lead to drug resistance and hinder the clinical response to therapy. The present research focuses on developing a novel formulation of LVM-loaded mesoporous silica nanoparticles (LVM-MSN) conjugated with Apolipoprotein E3 (ApoE3) for enhanced brain-targeting. LVM-MSN were prepared using the calcination method after optimizing different synthesis parameters. Chitosan was employed as capping agent to form LVM-Chito-MSN, which was characterized using zeta potential, XRD, FE-SEM, and TEM study. Further, LVM-Chito-MSN was functionalized by ApoE3 as brain-targeting ligand through direct coating approach (ApoE3@LVM-Chito-MSN). In-vivo pharmacokinetic study and biodistribution study indicated an impressive 3-fold increase in brain-uptake of ApoE3@LVM-Chito-MSN, with reduced distribution to other organs compared to LVM solution. The hemolysis study and histological examination of major organs indicated safety of the formulation. Consequently, functionalization of MSN with ApoE3 represents promising strategy for enhanced brain targeting, which could lead to improved patient compliance and better overall survival rates for patients suffering from brain tumor-related epilepsy.

100 项与 L. M. College of Pharmacy 相关的药物交易

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100 项与 L. M. College of Pharmacy 相关的转化医学

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