Prospective study of the safety after implantation of iSert Micro 255 Multicenter Study / Epidemiologic research - Prospective study of the safety after implantation of iSert Micro 255 Multicenter Study / Epidemiologic research

开始日期2014-01-06

申办/合作机构

Kureha Special Laboratory Co. Ltd.

100 项与 Kureha Special Laboratory Co. Ltd. 相关的临床结果

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0 项与 Kureha Special Laboratory Co. Ltd. 相关的专利（医药）

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项与 Kureha Special Laboratory Co. Ltd. 相关的文献（医药）

2016-05-01·Journal of Bone and Mineral Metabolism3区 · 医学

Differences in vertebral, tibial, and iliac cancellous bone metabolism in ovariectomized rats

3区 · 医学

Article

作者: Ishizuya, Toshinori ; Murayama, Hisashi ; Takakura, Aya ; Ejiri, Sadakazu ; Takao-Kawabata, Ryoko ; Kajiwara, Makoto ; Isogai, Yukihiro

Bone histomorphometry is usually performed on the iliac bone in humans and the tibia or vertebrae in rats. Bone metabolism differences among skeletal sites may be problematic when translating experimental results from rats to humans, but data on such differences in rats are lacking. Therefore, we examined the differences in bone structure and metabolism among skeletal sites using the lumbar vertebra (LV), tibia, and iliac bone obtained from ovariectomized or sham-operated rats preoperatively and at various times from 3 days to 26 weeks postoperatively. The trabeculae were thicker in the LV, where bone metabolism was less active than at other sites, and numerous fine trabeculae were observed in the tibia, where bone metabolism was more active. The iliac bone structure and metabolism were intermediate between those of the tibia and LV. Ovariectomy induced lower bone volume and higher bone metabolism in all skeletal sites, but the changes were greatest and occurred earliest in the tibia, followed by the iliac bone and then LV. Ovariectomy caused changes in bone metabolic markers, which occurred earlier than those in bone tissue. Activation frequency (Ac.f) increased after ovariectomy. At week 26 in ovariectomized rats, Ac.f was highest in the tibia (3.13 N/year) but similar between iliac bone (0.87 N/year) and LV (1.39 N/year). Ac.f is reportedly 0.3-0.4 N/year in the iliac bone of postmenopausal women, suggesting that bone turnover in rats is several times higher than in humans. The reference values reported here are useful for translating experimental results from rats to humans.

2015-05-01·Molecular and Clinical Oncology

Preoperative administration of polysaccharide Kureha and reduced plasma transforming growth factor-β in patients with advanced gastric cancer: A randomized clinical trial

Article

作者: Satoh, Toshihiko ; Yamashita, Keishi ; Nemoto, Masayuki ; Wang, Guoqin ; Shibata, Tomotaka ; Hoshi, Keika ; Mieno, Hiroaki ; Hemmi, Osamu ; Katada, Natsuya ; Ohtsuki, Shigeaki ; Sakuramoto, Shinichi ; Kikuchi, Shiro ; Sakamoto, Yasutoshi ; Watanabe, Masahiko

Systemic abrogation of TGF-β signaling results in tumor reduction through cytotoxic T lymphocytes activity in a mouse model. The administration of polysaccharide-Kureha (PSK) into tumor-bearing mice also showed tumor regression with reduced TGF-β. However, there have been no studies regarding the PSK administration to cancer patients and the association with plasma TGF-β. PSK (3 g/day) was administered as a neoadjuvant therapy for 2 weeks before surgery. In total, 31 advanced gastric cancer (AGC) patients were randomly assigned to group A (no neoadjuvant PSK; n=14) or B (neoadjuvant PSK therapy; n=17). Plasma TGF-β was measured pre- and postoperatively. The allocation factors were clinical stage (cStage) and gender. Plasma TGF-β ranged from 1.85-43.5 ng/ml (average, 9.50 ng/ml) in AGC, and 12 patients (38.7%) had a high value, >7.0 ng/ml. These patients were largely composed of poorly-differentiated adenocarcinoma with pathological stage III/IV. All the six elevated cases in group B showed a significant reduction of plasma TGF-β (from 21.6 to 4.5 ng/ml, on average), whereas this was not exhibited in group A. The cases within the normal limits of TGF-β remained unchanged irrespective of PSK treatment. Analysis of variance showed a statistically significant reduction in the difference of plasma TGF-β between groups A and B (P=0.019). PSK reduced the plasma TGF-β in AGC patients when the levels were initially high. The clinical advantage of PSK may, however, be restricted to specific histological types of AGC. Perioperative suppression of TGF-β by PSK may antagonize cancer immune evasion and improve patient prognosis in cases of AGC.

2011-04-01·Clinical calcium

[Morphological analysis of bone dynamics and metabolic bone disease. Bone histomorphometry for laboratory animals].

Review

作者: Yamato, Hideyuki ; Yajima, Nobuyuki ; Kajiwara, Makoto

The bone histomorphometry is well-known as the histological evaluation method for the investigation of the efficacy of various kinds of medicine on bone metabolism disorder. Recently, in addition, it is indispensable for bone researchers to clarify characteristic of bone metabolism in genetically-modified mice by means of bone histomorphometry. Thus, bone histomorphometry has broad utility. However, it would not be an exaggeration to say that researchers are interested in only numerical value of various kinds of parameters without understanding lots of information obtained from morphological observation. Especially, we have to pay attention to measurement and interpretation of parameters of bone histomorphometry in case of growing bone, because growing bone is changing its size of longitudinal and width. In this review, we would like to explain how to measure with bone histomorphometry for modeling bone in growing animals.

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100 项与 Kureha Special Laboratory Co. Ltd. 相关的转化医学

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