A Prospective, Multicenter, Single arm, Open Label study to Determine Cardiac MRI-Guided Deferiprone Therapy for Acute Myocardial Infarction Patients - NIL

开始日期2024-08-17

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Synergy Superspeciality Hospital

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2024-02-29·Indian Journal of Critical Care Medicine

Retrospective Analysis of Clinical Characteristics and Outcomes of Pregnant Women with SARS-CoV-2 Infections Admitted to Intensive Care Units in India (Preg-CoV): A Multicenter Study

Article

作者: Dobariya, Jayesh ; Paliwal, Naveen ; Sinha, Sharmili ; Karmakar, Saurabh ; Thakkar, Vipul P ; Mona, Aarti ; Mishra, Anand ; Karmata, Tejas ; Chaudhury, Alisha ; Prakash, Jay ; Padhi, Gunadhar ; Rath, Mayurdhwaja ; Srikant, Behera ; Bihani, Pooja ; Paul, Gunchan ; Ruparelia, Alpesh ; Singhal, Vinay ; Shah, Bhagyesh A ; Goyal, Alaukik

AimThe aim was to examine the outcomes of pregnant women admitted to intensive care unit with coronavirus disease-2019 (COVID-19) infection during the severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) pandemic in India. The primary outcome of the study was maternal mortality at day 30. The secondary outcomes were the intensive care unit (ICU) and hospital length of stay, fetal mortality and preterm delivery.Materials and methodsThis was a retrospective multicentric cohort study. Ethical clearance was obtained. All pregnant women of the 15-45-year age admitted to ICUs with SARS-CoV-2 infection during 1st March 2020 to 31st October, 2021 were included.ResultsData were collected from nine centers and for 211 obstetric patients admitted to the ICU with a confirmed diagnosis of COVID-19. They were divided in to two groups as per their SpO₂ (saturation of peripheral oxygen) level at admission on room air, that is, normal SpO₂ group (SpO₂ > 90%) and low SpO₂ group (SpO₂ < 90%). The mean age was (30.06 ± 4.25) years and the gestational age was 36 ± 8 weeks. The maternal mortality rate was10.53%. The rate of fetal death and preterm delivery was 7.17 and 28.22%, respectively. The average ICU and hospital length of stay (LOS) were 6.35 ± 8.56 and 6.78 ± 6.04 days, respectively. The maternal mortality (6.21 vs 43.48%, p < 0.001), preterm delivery (26.55 vs 52.17%, p = 0.011) and fetal death (5.08 vs 26.09%, p = 0.003) were significantly higher in the low SpO₂ group.ConclusionThe overall maternal mortality among critically ill pregnant women affected with COVID-19 infection was 10.53%. The rate of preterm birth and fetal death were 28.22 and 7.17%, respectively. These adverse maternal and fetal outcomes were significantly higher in those admitted with low SpO₂ (<90%) at admission compared with those with normal SpO₂.How to cite this articleSinha S, Paul G, Shah BA, Karmata T, Paliwal N, Dobariya J, et al. Retrospective Analysis of Clinical Characteristics and Outcomes of Pregnant Women with SARS-CoV-2 Infections Admitted to Intensive Care Units in India (Preg-CoV): A Multicenter Study. Indian J Crit Care Med 2024;28(3):265-272.

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