作者: Zhong, Xiangming ; Lin, Duohua ; Li, Huanqiong ; Wan, Zhonghe ; Yuan, Guilong ; Chen, Jun ; Mo, Wenhui ; Li, Caihuan ; Liu, Ling ; Dai, Yi-Heng ; Huang, Runzhong ; Shi, Jipeng

ObjectiveTo investigate the clinical characteristics and outcomes of newborns infected with coronavirus disease 2019 (COVID-19) during the Omicron wave.MethodsFrom December 1, 2022, to January 4, 2023, clinical data were collected from neonates with COVID-19 who were admitted to 10 hospitals in Foshan City, China. Their epidemiological histories, clinical manifestations and outcomes were analysed. The neonates were divided into symptomatic and asymptomatic groups. The t test or χ² test was used for comparisons between groups.ResultsA total of 286 children were diagnosed, including 166 males, 120 females, 273 full-term infants and 13 premature infants. They were 5.5 (0-30) days old on average when they were admitted to the hospital. These children had contact with patients who tested positive for COVID-19 and were infected through horizontal transmission. This study included 33 asymptomatic and 253 symptomatic patients, among whom 143 were diagnosed with upper respiratory tract infections and 110 were diagnosed with pneumonia. There were no severe or critical patients. Fever (220 patients) was the most common clinical manifestation, with a duration of 1.1 (1-6) days. The next most common clinical manifestations were cough with nasal congestion or runny nose (4 patients), cough (34 patients), poor appetite (7 patients), shortness of breath (15 patients), and poor general status (1 patient). There were no significant abnormalities in routine blood tests among the neonates infected with COVID-19 except for mononucleosis. However, compared with the asymptomatic group, in the symptomatic group, the leukocyte and neutrophil granulocyte counts were significantly decreased, and the monocyte count was significantly increased. C-reactive protein (CRP) levels were significantly increased (≥10 mg/L) in 9 patients. Myocardial enzyme, liver function, kidney function and other tests showed no obvious abnormalities.ConclusionsIn this study, neonates infected with the Omicron variant were asymptomatic or had mild disease. Symptomatic patients had lower leucocyte and neutrophil levels than asymptomatic patients.

Zhongguo Yixue Chuangxin

Effects of Esketamine Combined with Midazolam on Anesthesia Effect and Cognitive Function in Elderly Patients with Lower Limb Fracture Surgery

作者: Chen Yanheng ; Liang Ling ; Guan Zhirong ; Ou Jinhui ; Zhong Aiqun

Objective:To investigate the effect of Esketamine combined with Midazolam on anesthesia effect and cognitive function in elderly patients with lower limb fracture surgery.Method:A total of 92 elderly patients with lower limb fracture admitted to our hospital from Jan. 2019 to June 2020 were selected, and they were divided into control group and observation group according to random number table method, 46 cases in each group.The control group was anesthetized with Dexmedetomidine combined with Esketamine, and the study group was anesthetized with Esketamine combined with Midazolam.Anesthesia effect, adverse reactions, hemodynamics and cognitive function were compared between two groups.Result:The rate of excellent and good anesthesia in the study group was higher than that in the control group, and the incidence of adverse reactions in the study group was lower than that in the control group, the differences were statistically significant (P<0.05).At T_1, there were no significant differences in HR, MAP and CVP between two groups (P>0.05).At T_2-T_5, HR, there were no significant differences in HR, MAP and CVP between the control group and T_1 (P<0.05).At T_2-T_5, there were no significant differences in HR, MAP and CVP between the study group and T_1 (P>0.05).At T_2-T_5, HR, MAP and CVP in the study group were lower than those in the control group, the differences were statistically significant (P<0.05).The onset time of anesthesia in the study group was shorter than that in the control group, and the sedation and VAS scores in the study group were lower than those in the control group, the differences were statistically significant (P<0.05).Before surgery, there was no significant difference in MMSE score between two groups (P>0.05);1 and 3 d after surgery, MMSE scores in the study group were higher than those in the control group, the differences were statistically significant (P<0.05).Conclusion:The application of Esketamine combined with Midazolam in the external fixation of lower extremity fractures in elderly patients is effective, has little effect on hemodynamics, is beneficial to improve cognitive function, has ideal sedative effect, has fewer adverse reactions, is safe, which is worthy of extensive promotion.

Zhongguo Dangdai Yiyao

Influence of prenatal and postpartum comprehensive nursing on breast milk secretion and feeding mode of primipara

作者: Zeng Cai-xian ; Zeng Ke-hong ; Liang Chu-ying ; Wu Xiao-yan ; Wang Fu-hai

Objective To explore the effect of prenatal and postpartum comprehensive nursing on the feeding pattern and breast milk secretion of primipara.Methods A total of 500 primipara who delivered in our hospital from Jan. to June 2018 were selected and divided into control group and study group by random number table method, 250 cases in each group.The control group received routine nursing, the study group received prenatal and postpartum comprehensive nursing.The feeding mode, lactation volume and total nursing satisfaction of the two groups were compared.Results The breast-feeding rates of the study group and control group were 96.00% and 75.60%, resp.The breastfeeding situation of the study group was better than that of the control group(χ∼2=42.700, P=0.000); the breast-milk secretion of the study group was more than that of the control group(P<0.05); the total satisfaction rate of nursing in the study group was 98.80%, which was higher than that in the control group(84.80%), the difference was statistically significant(P<0.05).Conclusion Prenatal and postpartum carenursing for primipara can improve breast milk secretion and breast-feeding rate, help to promote the healthy growth of newborns, and has better clin. application value.

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100 项与佛山高明民众医院相关的转化医学

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