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疾病领域	数量

感染	1

排名前五的药物类型	数量

生物药	1

关联

1

项与 Zagazig University 相关的药物

Candida antigen immunotherapy(Zagazig University)

靶点-

作用机制-

在研机构

Zagazig University

原研机构

Zagazig University

在研适应症

疣

非在研适应症-

最高研发阶段临床2期

首次获批国家/地区-

首次获批日期-

375

项与 Zagazig University 相关的临床试验

NCT06524011 / Not yet recruitingN/AIIT

Split Face Comparative Study of Stromal Vascular Fraction Enriched PRP Versus Each Alone in Treatment of Atrophic Post-acne Scars

in a split face fashion, 30 patients will be randomized into 3 groups: Group A: rt side treated with SVF enriched PRP, lt side treated with prp Group B: rt side treated with SVF enriched PRP, lt side treated with SVF Group C: rt side treated with PRP, lt side treated with SVF

开始日期2024-12-01

申办/合作机构

Zagazig University

NCT06639659 / Not yet recruitingN/AIIT

Bilateral Supra-Zygomatic Sphenopalatine Ganglion Block Versus Dexmedetomidine for Relief of Postoperative Pain and Surgical Field Improvement in Trans-nasal Endoscopic Pituitary Surgery

Improving pain and surgical field by using sphenopalatine ganglion block and dexmedetomidine in trans-nasal endoscopic pituitary surgery.

开始日期2024-10-01

申办/合作机构

Zagazig University

NCT06620172 / Not yet recruitingN/AIIT

CT-guided vs Fluoroscopy-guided Trigeminal Ganglion Radiofrequency Thermocoagulation for Idiopathic Trigeminal Neuralgia: A Randomized Controlled Trial

The goal of this clinical trial is to compare the effectiveness and safety of CT-guided versus fluoroscopy-guided trigeminal ganglion radiofrequency thermocoagulation (TG-RFT) in treating idiopathic trigeminal neuralgia (TN) in adults aged 18 and older.
The main questions it aims to answer are:
* Does CT-guided TG-RFT provide better pain relief compared to fluoroscopy-guided TG-RFT?
* What are the differences in medication consumption between the two methods?
* What are the procedure-related adverse events for both methods?
Investigators will compare CT-guided TG-RFT to fluoroscopy-guided TG-RFT to see if one method is superior in treating idiopathic TN.
Participants will:
* Undergo either CT-guided or fluoroscopy-guided TG-RFT procedure
* Be monitored post-procedure and followed up at 1, 3, and 6 months for pain relief, medication consumption, and adverse events.

开始日期2024-10-01

申办/合作机构

Zagazig University

100 项与 Zagazig University 相关的临床结果

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0 项与 Zagazig University 相关的专利（医药）

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26,664

项与 Zagazig University 相关的文献（医药）

2025-02-01·Journal of Pipeline Systems Engineering and Practice

Modeling the Factors Affecting Sanitary System Condition Assessment in Egypt

作者: Ibrahim, Ahmed H. ; Elsadek, Mohamed A. ; Salman, Ahmed F.

2025-01-01·Comparative Biochemistry and Physiology Part B: Biochemistry and Molecular Biology

Effects of α-sitosterol on growth, hematobiochemical profiles, immune-antioxidant resilience, histopathological features and expression of immune apoptotic genes of Nile tilapia, Oreochromis niloticus, challenged with Candida albicans

Article

作者: El-Houseiny, Walaa ; El-Murr, Abd Elhakeem ; Alqhtani, Haifa A. ; Alqhtani, Haifa A ; Arisha, Ahmed H ; Bayoumi, Yasmin ; Al-Sagheer, Adham A. ; Abdelaziz, Rewan ; Al-Sagheer, Adham A ; Arisha, Ahmed H. ; Bin-Jumah, May Nasser ; Mansour, Abdallah Tageldein

In this study, the effect of the Streptomyces misakiensis metabolite (α- sitosterol, 0, 20, 40, 60, and 80 mg/kg) dietary supplementation on growth performance, antioxidant-immune stability and Candida albicans resistance of Nile tilapia was evaluated. The results revealed that the incorporation of α-sitosterol at doses of 60 and 80 mg/kg into the diet significantly improved the growth rate of Nile tilapia. The fish receiving 80 mg/kg showed an increased level of high-density lipoprotein, total protein, globulin, and albumin, and significantly reduced levels of indicators of hepato-renal damage, glucose, triglycerides, low-density lipoprotein, and total cholesterol. Dietary α-sitosterol induced a considerable increase in hepatopancreas glutathione peroxidase, superoxide dismutase and catalase activities and a significant drop in malondialdehyde levels. Supplementing the diet with 80 mg/kg of α-sitosterol increased nitric oxide, complement-3, nitro blue tetrazolium levels, lysozyme, and phagocytic activities. In particular, supplementing with α-sitosterol at 60-80 mg/kg of diet significantly enhanced the expression of pro/anti-inflammatory markers (il1b, il10, tgfb, ifng, tnfa and il8) after the C. albicans challenge. Also, there was a decrease in cumulative mortality percent, pro-apoptotic markers (casp3, bax and hsp70) and an increase in anti-apoptotic indicators (bcl2). Interestingly, following the C. albicans challenge, fish that received 0 and 20 mg α-sitosterol/kg exhibited significant inflammation in the hepatopancreas, spleen, and intestine. On the other hand, inflammation could be alleviated by feeding 60-80 mg α-sitosterol/kg. Due to these findings, α-sitosterol could be an innovative option to enhance growth, general physiological status, immune service, and antifungal resistance of Nile tilapia against C. albicans.

2025-01-01·Spectrochimica Acta Part A: Molecular and Biomolecular Spectroscopy

Novel quantum dots-based assay for the determination of anti-hypertensive drugs minoxidil and timolol in different matrices

Article

作者: El Sharkasy, Mona E. ; Ahmed, Esraa S ; Bahgat, Eman A ; Belal, Fathalla ; Ahmed, Esraa S. ; Saleh, Hanaa ; El Sharkasy, Mona E ; Bahgat, Eman A.

The present work reports a sensitive, affordable, and ecologically friendly spectrofluorimetric method for the assessment of two antihypertensive medications, namely minoxidil and timolol. Blue-emitting sulfur and nitrogen co-doped carbon quantum dots (S,N-CQDs) were generated by exposing soluble starch and thiourea to a 15-minute microwave treatment. The so- prepared nanodots displayed fluorescence at 276/430 nm with a quantum yield of 22 %. Inspection of the so-prepared nano-sensor verified their doping with nitrogen and sulfur, and their size was in the range of 4.5-9.03 nm. The proposed method was found to be rectilinear in the range of 0.20-5.0 and 2.0-30.0 µg/mL, with LOQs of 0.16 and 0.82 µg/mL for minoxidil and timolol, respectively. The developed method was employed to assess the concentrations of minoxidil and timolol in their pharmaceutical formulations, with %recoveries varying between 99.00 % and 101.94 %, and low RSD values (less than 2 %). The high sensitivity of the developed method allowed its use for timolol measurement in artificial aqueous humor, with % recoveries between 97.60 %.and 101.57 %. The study further examined how each analyte interacted with the prepared dots, leading to a quenching of their fluorescence. Additionally, an interference study was utilized to evaluate the specificity of the proposed approach through determining analyte levels in the existence of common additives, co-formulated drugs, and co-administered drugs. The analytical eco-scale, GAPI and AGREE assessment techniques were utilized to confirm the suggested method greenness.

100 项与 Zagazig University 相关的药物交易

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100 项与 Zagazig University 相关的转化医学

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