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41

项与 Bhumibol Adulyadej Hospital 相关的临床试验

TCTR20240503001 / RecruitingN/AIIT

The Structural Change of Fetal Brain Development among Diabetic Mother in Bhumibol Adulyadej Hospital

开始日期2024-04-10

申办/合作机构

Bhumibol Adulyadej Hospital

TCTR20240418005 / RecruitingN/AIIT

A comparison of fetal thymus size between pregnant women with diabetic and non-diabetic disease

开始日期2024-03-18

申办/合作机构

Bhumibol Adulyadej Hospital

NCT06254456 / Not yet recruitingN/AIIT

End Expiratory Occlusion Test and Tidal Volume Challenge Test for Assess Fluid Responsiveness in Prone Patients

To assess fluid responsiveness in prone patient

开始日期2024-03-01

申办/合作机构

Bhumibol Adulyadej Hospital

100 项与 Bhumibol Adulyadej Hospital 相关的临床结果

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0 项与 Bhumibol Adulyadej Hospital 相关的专利（医药）

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225

项与 Bhumibol Adulyadej Hospital 相关的文献（医药）

2024-12-31·Renal Failure

SGLT2 inhibitor dapagliflozin reduces proximal tubular cell damage biomarkers in patients with acute heart failure

Article

作者: Chuasuwan, Anan ; Gojaseni, Pongsathorn ; Wattanakul, Jananya ; Chittinandana, Anutra

2024-08-01·Neurology Genetics

CGG/CCG Repeat Expansions in LOC642361/NUTM2B-AS1 in Thai Patients With Oculopharyngodistal Myopathy

Article

作者: Witoonpanich, Rawiphan ; Termglinchan, Thanes ; Dejthevaporn, Charungthai ; Lida, Aritoshi ; Apiwattanakul, Metha ; Nishino, Ichizo ; Lee, Theeraphong ; Yamanaka, Ai ; Funaguma, Shunsuke ; Pongpakdee, Sunsanee ; Wansophonkul, Supika

ObjectivesThis study characterizes oculopharyngodistal myopathy in 4 Thai patients from 3 families with CGG/CCG repeat expansion in LOC642361/NUTM2B-AS1.MethodsRepeat-primed PCR analyzed CGG/CCG repeat size in LOC642361/NUTM2B-AS1 in 4 Thai patients suspected of oculopharyngodistal myopathy (OPDM). Clinical records were reviewed for clinicopathologic features.ResultsAll patients exhibited strong somatic instabilities of the expanded CGG/CCG repeats, primarily manifesting as oculopharyngeal weakness. Patient 1 had mild finger extensor and intrinsic hand muscle weakness, and although patient 2 lacked limb weakness, both siblings showed electrophysiologic evidence of distal myopathy, indicative of OPDM. Patient 3, the daughter of a sibling with OPDM reported in 2004, lacked limb weakness or leukoencephalopathy on brain MRI. Patient 4, initially misdiagnosed with refractory myasthenia gravis, had generalized muscle weakness.DiscussionWhile initially characterized as oculopharyngeal myopathy with leukoencephalopathy (OPML) in a Japanese family, our study suggests a stronger association between CGG/CCG expansion in LOC642361/NUTM2B-AS1 and oculopharyngodistal myopathy (OPDM) rather than OPML. The variable presence or absence of leukoencephalopathy further supports OPDM as the predominant clinical manifestation linked to CGG/CCG expansion in LOC642361/NUTM2B-AS1.

2024-07-01·Pediatrics & Neonatology

Development and survey of a questionnaire to measure parental perceptions of childhood defecation and constipation

Article

作者: Dumrisilp, Termpong ; Tanwarawutthikul, Chutima

BACKGROUNDThere are insufficient data and measuring tools for parental perception of defecation and constipation in Thai children. The primary objective of this study was to develop a tool to measure parental perceptions towards defecation and constipation in children. The secondary objective was to identify parental understanding and misconceptions about these issues.METHODSThe authors developed a questionnaire in three domains: knowledge, attitude, and practice. Content validity was evaluated using the item-objective congruence index (IOC) by five experts. The reliability of the measure was assessed based on both internal consistency and test-retest reliability. Then, a descriptive cross-sectional survey was conducted on Thai parents at pediatric outpatient clinics and wards in Bhumibol Adulyadej Hospital.RESULTSThe authors developed a first draft questionnaire consisting of 31 items, which were categorized into three domains of knowledge, attitude, and practice. During expert validation, five items were disqualified. To assess the questionnaire's reliability, Cronbach's alpha value was calculated and found to be 0.229 for the original questionnaire. However, after removing irrelevant questions, Cronbach's alpha value increased to 0.511 for an 18-item questionnaire. The adjusted questionnaire demonstrated excellent test-retest reliability (Intraclass correlation coefficient, ICC = 0.91). The survey with 306 parents revealed parental misconceptions about the pathophysiology of stool withholding, stool soiling indicating constipation, toilet training after meals, and monitoring bowel movements.CONCLUSIONThe developed questionnaire helps to assess parental perception regarding defecation and constipation in Thai children. Based on the survey results, the authors suggest that parental education on these issues is still necessary.

100 项与 Bhumibol Adulyadej Hospital 相关的药物交易

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100 项与 Bhumibol Adulyadej Hospital 相关的转化医学

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