A 26-week, Randomized, Open-label, Parallel-groupComparison of SAR341402 Mix 70/30 to NovoMixÂ®30 inAdult Patients with Diabetes Mellitus using Pre-mixInsulin Analogs - GEMELLI M

开始日期2019-09-05

申办/合作机构

Sanofi-Synthelabo (India) Pvt Ltd.

CTRI/2019/03/018075 / Completed临床3期

A multi-center open-label parallel group randomized controlled trial to compare iGlarLixi versus premixed insulin in patients with type 2 diabetes who have failed to achieve glycemic control with basal insulin and oral antidiabetic agents - GLOBAL PREMIX

开始日期2019-03-29

申办/合作机构

Sanofi-Synthelabo (India) Pvt Ltd.

CTRI/2019/01/016928 / Completed临床3期

A randomized, double blind, placebo-controlled, parallel-group phase 3 study to evaluate the efficacy and safety of Dupilumab in patients with persistent asthma - Dupilumab

开始日期2019-01-25

申办/合作机构

Sanofi-Synthelabo (India) Pvt Ltd.

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2018-06-01·Tumor Biology

Decreased expression of cell adhesion genes in cancer stem-like cells isolated from primary oral squamous cell carcinomas

Article

作者: Chandarana, Pinal ; Govindarajan, Raman ; Ramaswamy, S. ; Sriram, Harshini ; Mishra, Amrendra ; Sadasivam, Subhashini ; Tanavde, Vivek ; Gopinath, Ashok ; Kumar, Rekha V

The goal of this study was to isolate cancer stem-like cells marked by high expression of CD44, a putative cancer stem cell marker, from primary oral squamous cell carcinomas and identify distinctive gene expression patterns in these cells. From 1 October 2013 to 4 September 2015, 76 stage III–IV primary oral squamous cell carcinoma of the gingivobuccal sulcus were resected. In all, 13 tumours were analysed by immunohistochemistry to visualise CD44-expressing cells. Expression of CD44 within The Cancer Genome Atlas–Head and Neck Squamous Cell Carcinoma RNA-sequencing data was also assessed. Seventy resected tumours were dissociated into single cells and stained with antibodies to CD44 as well as CD45 and CD31 (together referred as Lineage/Lin). From 45 of these, CD44+Lin– and CD44–Lin– subpopulations were successfully isolated using fluorescence-activated cell sorting, and good-quality RNA was obtained from 14 such sorted pairs. Libraries from five pairs were sequenced and the results analysed using bioinformatics tools. Reverse transcription quantitative polymerase chain reaction was performed to experimentally validate the differential expression of selected candidate genes identified from the transcriptome sequencing in the same 5 and an additional 9 tumours. CD44 was expressed on the surface of poorly differentiated tumour cells, and within the The Cancer Genome Atlas–Head and Neck Squamous Cell Carcinoma samples, its messenger RNA levels were higher in tumours compared to normal. Transcriptomics revealed that 102 genes were upregulated and 85 genes were downregulated in CD44+Lin– compared to CD44–Lin– cells in at least 3 of the 5 tumours sequenced. The upregulated genes included those involved in immune regulation, while the downregulated genes were enriched for genes involved in cell adhesion. Decreased expression of PCDH18, MGP, SPARCL1 and KRTDAP was confirmed by reverse transcription quantitative polymerase chain reaction. Lower expression of the cell–cell adhesion molecule PCDH18 correlated with poorer overall survival in the The Cancer Genome Atlas–Head and Neck Squamous Cell Carcinoma data highlighting it as a potential negative prognostic factor in this cancer.

2017-01-01·International Journal of Infectious Diseases3区 · 医学

Dengue serotype-specific seroprevalence among 5- to 10-year-old children in India: a community-based cross-sectional study

3区 · 医学

ArticleOA

作者: Goyal, Ram Chandra ; Jammy, Guru Rajesh ; Ferreira, Germano ; Masthi, N R Ramesh ; Nealon, Joshua ; Garg, Suneela ; Sharma, Nandini ; Chakravarti, Anita ; Singh, M M ; Ganguly, Enakshi ; Ojha, Sujeet ; Singh, Ritesh ; Moureau, Annick

BACKGROUNDDengue surveillance data in India are limited and probably substantially underestimate the burden of disease. A community-based study was undertaken to assess the prevalence of dengue-specific immunoglobulin G (IgG) antibodies in children across India and to examine historical dengue exposure rates. Potential associations between socio-economic factors and dengue seroprevalence were also assessed (registered at ctri.nic.in: CTRI/2011/12/002243).METHODSA convenience sample of 2609 healthy children aged 5-10 years was enrolled; these children were registered at or were living in the vicinity of eight centres located at six geographically distinct sites across India. Blood samples were drawn to test for the presence of dengue IgG antibodies using ELISA. Serotype-specific neutralizing antibody titres were measured in dengue IgG-positive children using dengue plaque reduction neutralization tests. Socio-demographic and household information was collected using a questionnaire.RESULTSOverall, 2558/2609 children had viable samples with laboratory results for dengue IgG. Dengue IgG seroprevalence across all sites was 59.6% (95% confidence interval 57.7-61.5%): the lowest (23.2%) was in Kalyani, West Bengal, and the highest (80.1%) was in Mumbai. Seroprevalence increased with age. Multivariate analysis suggested associations with household water storage/supply and type of housing. Half of the subjects with positive IgG results presented a multitypic profile, indicating previous exposure to more than one serotype.CONCLUSIONSThe overall dengue seroprevalence suggests that dengue endemicity in India is comparable to that in highly endemic countries of Southeast Asia. Additional prospective studies are required to fully quantify the disease burden, in order to support evidence-based policies for dengue prevention and control in India.

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