Investigating the Effect of Use of Cobalt Ferrite -Conjugated Chitosan-Betaine Facial Masks in improvement and acceleration of treatment in patients with Acne Vulgaris

开始日期2024-07-14

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Medical University of Ilam

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372

项与 Medical University of Ilam 相关的文献（医药）

2023-08-01·Virus Genes

Immune response induced by recombinant pres2/S-protein and a pres2-S-protein fused with a core 18-27 antigen fragment of hepatitis B virus compared to conventional HBV vaccine

Article

作者: Khosravi, Afra ; Amani, Jafar ; Behzadi, Elham ; Imani Fooladi, Abbas Ali ; Parizad, Elaheh Gholami ; Sedighian, Hamid

Although comprehensive vaccination is the cornerstone of public health programs to control hepatitis B virus (HBV) infections, 5% of people who receive the existing vaccine do not develop proper immunity against HBV. To overcome this challenge, researchers have tried using various protein fragments encoded by the virus genome to achieve better immunization rates. An important antigenic component of HBsAg called the preS2/S or M protein has also received much attention in this area. The gene sequences of preS2/S and Core18-27 peptide were extracted from the GenBank (NCBI). Final gene synthesis was conducted with pET28. Groups of BALB/c mice were immunized with 10 μg/ml of recombinant proteins and 1 μg/ml CPG7909 adjuvant. Serum levels of IF-γ, TNF-α, IL-2, IL-4, and IL-10 were measured by ELISA assay method on spleen cell cultures on day 45, and IgG1, IgG2a, and total IgG titers obtained from mice serum were quantified on days 14 and 45. Statistical analysis did not show any significant difference between the groups regarding IF-γ level. There were, however, significant differences in terms of IL-2 and IL-4 levels between the groups receiving preS2/S-C18-27 with and without adjuvant and the groups receiving both preS2/S and preS2/S-C18-27 (Plus Recomb-Plus Recomb: the group of mice that received both preS2/S and preS2/S-C18-27 simultaneously). The strongest total antibody production was induced by immunization with both recombinant proteins without CPG adjuvant. The groups that received both preS2/S and preS2/S-C18-27, whether with or without adjuvant, were significantly different from those that received the conventional vaccine considering most abundant interleukins. This difference suggested that higher levels of efficacy can be achieved by the use of multiple virus antigen fragments rather than using a single fragment.

2023-07-01·Journal of the Iranian Chemical Society

Efficient sonocatalytic degradation of orange II dye and real textile wastewater using peroxymonosulfate activated with a novel heterogeneous TiO2–FeZn bimetallic nanocatalyst

作者: Jaafarzadeh, Neemat ; Amarloei, Ali ; Noorimotlagh, Zahra ; Mirzaee, Seyyed Abbas ; Martinez, Susana Silva ; Dehvari, Mahboobeh

TiO2-FeZn nanocatalyst combined with sonolysis were used to activate peroxymonosulfate (PMS) as a highly efficient advanced oxidation process (US/TiO2-FeZn/PMS) for the decoloration of orange II dye (OII) and real textile wastewater.The characterization of the as-synthesized NPs was performed by SEM, FTIR, EDX and XRD analyses.Optimal exptl. conditions of operational parameters were obtained: pH = 3, 15 mg/L initial OII concentration, 0.2 g/L PMS, 0.7 g/L nanocatalyst dosing, and 300 W ultrasonic power.The decolorization was observed to increase with increasing the dose of nanocatalyst and the ultrasonic power, and with decreasing pH (under acidic conditions).Under optimal exptl. conditions, decolorization and COD removal of textile wastewater were 99.9% and 74.6%, resp., at 40 min.The TiO2-FeZn/PMS/US as a novel process exhibited a higher removal of OII (95%) than TiO2 NPs/PMS/US process (54%).The OII removal efficiency by the different processes decreased in the following order: TiO2-FeZn/US/PMS > TiO2-FeZn/PMS > TiO2-FeZn/US > TiO2 /US/PMS > US/PMS > TiO2-FeZn > PMS > US.The recyclability study revealed that the process could be reused up to three consecutive cycles.The current US/nanocatalyst/PMS system was concluded to be an efficient, reusable and stable nanocatalyst for the oxidation of textile dyes.

2023-07-01·Molecular biology reports

Nosocomial infections and antimicrobial susceptibility patterns among patients admitted to intensive care unit of Imam Khomeini hospital in Ilam, Iran.

Article

作者: Hashemian, Marzieh ; Bagheri, Mohammad Reza ; Kazemian, Hossein ; Kaviar, Vahab Hassan ; Khoshnood, Saeed ; Karamolahi, Somayeh ; Nazari, Ali ; Sadeghifard, Nourkhoda

INTRODUCTIONNosocomial infections (NIs) are a major challenge worldwide. Identification of antibiotic resistance pattern extended spectrum beta-lactamases (ESBLs) and carbapenem-resistant Enterobacteriaceae (CRE) were the objectives of this study.METHODSIn this cross-sectional study, the antimicrobial susceptibility pattern of bacterial isolates collected from patients with NIs in ICU was determined. Overall, 42 Escherichia coli and Klebsiella pneumoniae isolates from different infection sites were used to determine phenotypic tests of ESBLs, Metallo-β-lactamases (MBLs) and CRE. Detection of ESBLs, MBLs and CRE genes were performed by the polymerase chain reaction (PCR) method.RESULTSFrom 71 patients with NIs, 103 different bacterial strains were isolated. The most frequently isolated bacteria were E. coli (n = 29; 28.16%), Acinetobacter baumannii (n = 15; 14.56%), and K. pneumoniae (n = 13; 12.26%). Also, the rate of multidrug-resistant (MDR) isolates was 58.25% (60/103). Based on phenotypic confirmation tests, 32 (76.19%) isolates of E. coli and K. pneumoniae produced ESBLs, and 6 (14.28%) isolates were identified as CRE producers. PCR showed the high prevalence of the bla_CTX-M (n = 29; 90.62%) in ESBL genes. In addition, bla_NDM was detected in 4 (66.66%), bla_OXA-23 in 3 (50%), and bla_OXA-48 gene in 1 (16.66%) isolates. The bla_VIM, bla_KPC, and bla_IMP genes were not detected in any of the isolates.CONCLUSIONThe Gram-negative bacteria E. coli, A. baumannii, and K. pneumoniae with high resistance levels were the most common bacteria causing NIs in the ICU. This study for the first time identified bla_OXA-11, bla_OXA-23, and bla_NDM-1 genes in E. coli and K. pneumoniae in Ilam city of Iran.

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