更新于：2024-11-01

Alfred Fournier Institute

私营公司|

France

私营公司|

France

更新于：2024-11-01

概览

关联

项与 Alfred Fournier Institute 相关的临床试验

NCT04664985 / Unknown statusN/A

Evaluation of Mucogyne® Ovule in Vulvovaginal Dryness Management in Women Treated by Brachytherapy and/or Radiotherapy for Endometrial or Cervical Cancer.

Randomized, open-label, national (France), multicenter, prospective clinical study, to evaluate the superiority of Mucogyne® ovules over the control group on vaginal health (including hydration) in women treated by brachytherapy and/or radiotherapy for endometrial or cervical cancer.

开始日期2020-10-06

申办/合作机构

Alfred Fournier Institute

[+2]

100 项与 Alfred Fournier Institute 相关的临床结果

登录后查看更多信息

0 项与 Alfred Fournier Institute 相关的专利（医药）

登录后查看更多信息

186

项与 Alfred Fournier Institute 相关的文献（医药）

2023-11-01·La Revue du praticien

Institut Alfred-Fournier, cent ans de lutte contre les IST.

Article

作者: Bourée, Patrice

2023-08-02·JAC-Antimicrobial Resistance

P03 Effects of a dietary supplement containing probiotics, cinnamon and cranberry extracts in the prevention of recurrent cystitis

作者: Dauchet, Q ; Leblanc, A ; Ait Abdellah, S ; Bohbot, J M

AbstractObjectivesA study was conducted to evaluate the effects of a dietary supplement containing two probiotic strains (Lactobacillus helveticus LA201 and Lactobacillus plantarum BL3706, 5×109 cfu per two tablets) and extracts of cinnamon (320 mg) and cranberry (100 mg) in the prevention of recurrent cystitis.MethodsA total of 80 women (18–65 years) were included who reported at least two episodes of cystitis in the past 6 months, at least one of which was a bacterial cystitis confirmed by a urine cytobacteriological examination or a physician, and for whom the episodes of cystitis had a strong impact on their quality of life (QoL; Acute Cystitis Symptom Score [ACSS] QoL questionnaire >2). Participants took two tablets of the supplement per day for 6 months (n=37; Group 1) or no supplement (n=38; Group 2). The ACSS questionnaire was completed every 15 days, or in case of cystitis, for 8 months (total score ranged from 0 [no urinary discomfort] to 39 [maximum discomfort]). The two groups were comparable at baseline, with a higher proportion of postmenopausal women in Group 1.ResultsDuring the 6 months, 2/3 of the women in Group 1 had no recurrence of cystitis (0 symptomatic cystitis episodes [SCE]) while 2/3 of the women in Group 2 had at least one SCE (P=0.03 Fisher test). The total ACSS score during SCE was significantly lower in Group 1 (8.4±5.1 versus 12±5.9, P<0.0001 ANOVA), with results in favour of Group 1 for dimensions assessing typical symptoms of acute cystitis and QoL. Compliance and tolerance were excellent.ConclusionsThese results suggest that the supplement may help prevent recurrence of cystitis, particularly in postmenopausal women who are at high risk.

2022-04-22·Crescent Journal of Medical and Biological Sciences

Evaluation of the Effects of Bunium persicum and Albendazole on Killing Hydatid Cyst Protoscolices In Vitro

作者: Shaarbaf, Faezeh ; Bouree, Patrice ; Haji Abedin Rangraz, Mehrnaz ; Khaki, Arash ; Garedaghi, Yagoob

Objectives: Hydatidosis is a parasitic disease of zoonoses and the best treatment for this parasitic disease is cryosurgery. From time immemorial, many protoscolice-destroying chemicals have been used to inhibit the distribution of protoscolices within the cyst during surgery. However, the side effects of chemical compounds and medicinal plants should always be considered. Due to the antiparasitic properties of Bunium persicum (Boiss), this study was performed to evaluate and compare the effects of B. persicum (Boiss) essential oil and albendazole on protoscolices inside hydatid cyst in vitro. Materials and Methods: In this study, the essential oil used from the desired plant seeds was prepared. Gas chromatography-mass spectrometry was performed to determine its components. Hydatid cyst protoscolices were extracted from hydatid cyst-infected livers and exposed to B. persicum (Boiss) (2.5, 5, and 10 μg/mL) for 10, 30, 60, and 120 minutes, respectively. The viability of protoscolices was measured by the effect of plant essential oil by eosin staining. Albendazole was also used as an effective antiparasitic drug in this study. Results: The amount of essential oil protoscolices at 2.5 μg/mL in 10, 30, 60, and 120 minutes was 48.5%, 68.2%, 79.5%, and 96.1%, respectively. The antiparasitic drug albendazole showed less toxic effects at similar doses at the same intervals, but both treatment groups had a significant effect (P<0.001). The highest toxic effects of essential oil were observed at a concentration of 10 μg/mL 30 minutes after treatment. For albendazole, this effect was achieved at a dose of 10 μg/mL after 2 hours. Conclusions: The results and statistical data of this study showed that the essential oil of B. persicum (Boiss) in comparison with the antiparasitic drug albendazole has an acceptable scolicide effects in hydatidosis and can be used as an alternative to scolicide compound.

100 项与 Alfred Fournier Institute 相关的药物交易

登录后查看更多信息

100 项与 Alfred Fournier Institute 相关的转化医学

登录后查看更多信息