Delving into the Latest Updates on Universita Degli Studi G D'Annunzio Chieti with Synapse

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疾病领域	数量

肿瘤	1

排名前五的药物类型	数量

ADC	1

排名前五的靶点	数量

DNA x TEM	1

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1

项与 Universita Degli Studi G D'Annunzio Chieti 相关的药物

MP-TEM-1-ADC(MediaPharma Srl)

靶点

DNA x TEM

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DNA抑制剂 [+1]

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Universita Degli Studi G D'Annunzio Chieti

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MediaPharma Srl

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结直肠癌 [+3]

非在研适应症-

最高研发阶段临床前

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100 项与 Universita Degli Studi G D'Annunzio Chieti 相关的临床结果

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0 项与 Universita Degli Studi G D'Annunzio Chieti 相关的专利（医药）

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234

项与 Universita Degli Studi G D'Annunzio Chieti 相关的文献（医药）

2024-05-16·European Heart Journal Supplements

NOT JUST A SIMPLE BIRTH: SPONTANEOUS CORONARY ARTERY DISSECTION IN A YOUNG MOTHER

作者: Gallina, S ; Ricci, F ; Caprio, M ; Ottaviani, A ; Renda, G

AbstractA 33–year–old Caucasian woman with no cardiovascular history was admitted to the gynecology department due to a threat of preterm birth. During hospitalization, the patient experienced chest pain complicated by ventricular fibrillation. Resuscitation maneuvers were performed, followed by an emergency cesarean section with fetal extraction and DC shock, resulting in return of spontaneous circulation. Coronary angiography revealed spontaneous dissection of the first marginal branch, treated with conservative strategy. After 3 days, another episode of chest pain occurred with evidence of inferolateral STEMI. Emergency coronary angiography showed severe stenosis in the proximal segment of the circumflex branch and the mid–segment of the anterior descending branch; OCT confirmed spontaneous coronary dissection (SCAD) in these vessels. A conservative strategy was adopted, with medical therapy including DAPT for a year, ACE inhibitor and beta–blocker. After 1 month, a follow–up OCT of the coronary arteries showed almost complete resolution of the previously observed dissections. 7 years later, the patient presented to the emergency room with chest pain similar to the previous episode. A diagnosis of NSTEMI was made and the patient was admitted to the cardiac intensive care unit. Coronary angiography revealed spontaneous dissection of the right coronary artery causing occlusion in the mid–segment. Coronary angioplasty guided by IVUS was performed with a drug–coated balloon achieving TIMI 3 flow. Given the patient‘s medical history and suspicion of fibromuscular dysplasia, further diagnostic evaluation was conducted with CT angiography of the intracranial circulation, revealing double focal dissections in the both carotid arteries asymptomatic and without flow obstruction. The patient was discharged, prescribed SAPT and scheduled for follow–up with coronary and intracranial circulation CT angiography. SCAD is defined as an epicardial coronary artery dissection that is not associated with atherosclerosis. It commonly occurs in patients with few traditional cardiovascular risk factors. Its cause is hypothesized to be multifactorial with contributions from underlying arteriopathies, hormonal influences or systemic inflammatory diseases, often compounded by environmental precipitants or stressors. The abstract emphasizes the challenges of diagnosis, limited understanding of pathophysiology and the absence of well–defined guidelines regarding the treatment of SCAD.

2024-01-01·European Journal of Medicinal Chemistry

A systematic review on the current status of PSMA-targeted imaging and radioligand therapy

Review

作者: Capasso, Giuseppe ; Stefanucci, Azzurra ; Tolomeo, Anna

Prostate specific membrane antigen (PSMA) has been the subject of several studies in recent decades as a promising molecular target for prostate cancer (PCa), in fact it is considered an excellent molecular target for both PCa imaging (both for staging and follow-up), by means of PET/CT and for radioligand therapy. Its interesting molecular features have enabled the development of a new diagnostic and therapeutic approach for PCa, called "theranostics." Considering the abundance of PSMA-based probes that have appeared so far in the literature, the present work focuses the attention on radiopharmaceuticals with increasing clinical application, highlighting advantages and disadvantages in terms of different metabolization and excretion processes, pharmacokinetic, binding affinity and variable internalization rate, tumor-to-background ratio, residence times and toxicity profile.

2023-12-04·MDCCC 1800

I ritratti di Napoleone dipinti da Andrea Appiani: un inedito e alcune precisazioni

作者: Leone, Francesco

Andrea Appiani (1754‑1817) was the inventor of Napoleon’s iconography in Italy, whose myth he shaped through the portraits he dedicated to him. These paintings show the different iconographic approaches that Bonaparte gave to his image over time. This essay compares the well-known portraits of Napoleon painted by Appiani with a significant unpublished canvas, setting out specific circumstances and dates from archival documents and ancient sources beneath the lens of previous bibliography.

100 项与 Universita Degli Studi G D'Annunzio Chieti 相关的药物交易

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100 项与 Universita Degli Studi G D'Annunzio Chieti 相关的转化医学

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