A Clinical Study of the Effects of Cyclodynon® Compared With a Control Group on Reducing the Cumulative Risk of Breast Cancer Development in a Female Population Aged 40-52 Years With Mastodynia and BI-RADS Category 3

Increased mammographic density of mammary gland tissues and hyperprolactinaemia are regarded as one of the risk factors for the development of breast cancer in women aged 40 to 52 years, which necessitates closer monitoring of the mammary gland and can be considered as modifiable. The herbal drug Cyclodynone® has a dopaminergic effect on the hypothalamus, which causes its inhibitory effect on the secretion of prolactin. At present, a significant positive clinical and scientific experience has been accumulated in the use of the Cyclodynone® for the treatment of benign breast dysplasias against a background of mild hyperprolactinaemia in women of reproductive age. Demonstration of the positive effect of this drug on the reduction of hyperprolactinemia, mammographic density of MF, evaluation on the scale BI-RADS would justify its application for the modification of this risk factor in women aged 40 to 52 years.

开始日期2020-07-22

申办/合作机构

National University of Pharmacy

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项与 National University of Pharmacy 相关的文献（医药）

2025-04-17·Current Medicinal Chemistry

Anti-cancer Properties of Epigallocatechin-3-gallate (EGCG) and its Signaling Pathways

Article

作者: Bjørklund, Geir ; Gasmi, Amin ; Uminska, Kateryna ; Peana, Massimiliano ; Gasmi Benahmed, Asma ; Menzel, Alain ; Mykhailenko, Olha ; Georgiyants, Victoriya ; Piscopo, Salva

Abstract:Green tea is a traditional drink found in Asian countries, made up of four derivatives. One of the derivatives is epigallocatechin-3-gallate (EGCG). EGCG provides therapeutic benefits for cancer, heart disease, diabetes, and obesity. However, its poor absorption and instability limit its effectiveness, which can be improved using nanoparticle encapsulation. This work is a comprehensive review of the studies on green tea polyphenols, the impact of pro-oxidants and EGCG in cancer prevention, and their delivery using nanotechnology. Other plant sources of ellagitannin and its physicochemical properties, the therapeutic and preventive role of EGCG in breast cancer, and other cancers that can be treated using nano gold (NpAu) carriers are also discussed.

2025-03-05·Current Medicinal Chemistry

Minerals and Trace Elements: Key Protectors of Skin Health and Defenders Against Skin Disorders

Article

作者: Gheorghe, Emma ; Kassym, Laura ; Shanaida, Mariia ; Kussainova, Assiya ; Voloshyn, Volodymyr ; Shanaida, Volodymyr ; Hangan, Tony ; Semenova, Yuliya ; Bjørklund, Geir ; Lysiuk, Roman ; Gontova, Tetiana ; Voloshyn, Olena

Abstract:Skin is the human body's largest organ, protecting it from various environmental threats. At the same time, it is the most accessible organ of the body, which ensures the reception of stimuli and contact with the environment. Such common signs of skin aging, such as wrinkles, fine lines, and discoloration, result from both extrinsic and intrinsic factors that act for a long time. If the skin does not look well enough, it is worth investigating whether minerals or trace elements are deficient. The positive role of some minerals (calcium, potassium, sodium, sulfur, and magnesium) and trace elements (iron, zinc, selenium, copper, manganese, and silicon) was found in maintaining skin health. There are also a variety of skin conditions, such as inflammatory disorders (eczema, psoriasis), acne, lichen planus, vitiligo, alopecia areata, or even skin cancer, which require specific approaches for their prevention and treatment considering the saturation of the body and the skin with mineral elements. They could be supplied internally (through adequate nutrition or food additives) or externally (by application of cosmetics). Some aspects of the danger of the toxic trace elements used in cosmetics are also described in this review.

2025-03-01·Annals of Medicine & Surgery

Enhancing patient care: pharmacotherapeutic monitoring in community pharmacies – a literature review

Review

作者: Inshutiyimana, Samuel ; Wojtara, Magda ; Ramadan, Nagham ; Mshaymesh, Sarah ; Hammoud, Doha ; Uwishema, Olivier ; Ghanem, Laura

Background:The role of community pharmacies has been transitioning from traditional drug dispensing methods to include more patient-centered services such as pharmacotherapeutic monitoring. With the increasing complexity of medication regimens and the rising prevalence of chronic diseases, pharmacotherapeutic monitoring plays a crucial role in preventing medication-related problems. This study aims to review patient outcomes of community pharmacies’ involvement in pharmacotherapeutic monitoring services. It also highlights advances in the monitoring process, the challenges involved, and relevant solutions.Methods:A narrative review was conducted from 8 April 2024 to 9 May 2024, where data were extracted from multiple research studies indexed in PubMed, EBSCOHost, and Google Scholar databases. This review included only previous articles written in English and had information relevant to community pharmacy, patient care, innovations in pharmacotherapeutic monitoring, and challenges associated with the monitoring process in community pharmacies.Results:Implementation of pharmacotherapeutic monitoring in community pharmacies improves patient outcomes and satisfaction. It minimizes adverse events by ensuring optimal dosing and patient adherence, which in turn reduces medical expenses and duration of hospitalization. However, factors such as inefficient analytical resources, lack of skilled personnel, and huge financial costs complicate implementation of pharmacotherapeutic monitoring in community pharmacies.Conclusion:Community pharmacies’ participation in therapeutic drug monitoring is a promising development that prioritizes tailored patient care, eliminating the need for hospital visits. We recommend a multidisciplinary collaboration, robust electronic medical record systems, and large-scale research studies to provide sufficient evidence on the application of therapeutic drug monitoring in community pharmacies, to leverage this service. Also, policy and decision-makers should facilitate this practice by investing more in pharmacotherapeutic monitoring tools and training for community pharmacists.

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