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更新于：2026-01-20
Anhui Agricultural University
更新于：2026-01-20
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100 项与 安徽农业大学 相关的临床结果
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2026-04-01FOOD MICROBIOLOGY
Rapid and visual detection of Listeria monocytogenes by combining one-pot LAMP–CRISPR/Cas12b with lateral flow assay
Article
作者: Jia, Jianye ; Liao, Hongyan ; Wang, Guijun ; Liu, Xuelan ; Yin, Yuelan ; Wang, Shiqi ; Guo, Xiaoxi ; Zheng, Yuting ; Yuan, Chunyan ; Chen, Zhiwei ; Wang, Jialing ; Hu, Qinghai
Listeria monocytogenes, the leading cause of fatalities worldwide among foodborne pathogens, poses serious risks to food safety and public health. Therefore, a rapid and accurate detection method is crucial for early interception and effective management. In this study, a one-pot LAMP-CRISPR/Cas12b detection system based on the lmo0753 gene was developed for rapid detection of L. monocytogenes by combining loop-mediated isothermal amplification (LAMP) with a CRISPR/Cas12b assay. Further integration of a lateral flow assay (LFA) to develop a LAMP-CRISPR/Cas12b-LFA assay enabled direct detection of the results on the strips with the naked eye. Nine L. monocytogenes strains belonging to eight serotypes tested positive with both the one-pot LAMP-CRISPR/Cas12b and LAMP-CRISPR/Cas12b-LFA assays. Two assays did not show cross-reactivity with L. innocua and eight other foodborne bacteria. The limits of detection were 10 CFU/mL for pure culture and 20 CFU/g for spiked pork samples. Moreover, the enrichment time was substantially shortened to 3 h for pork samples spiked with only L. monocytogenes F2365, and 4-5 h for pork samples spiked with mixed bacteria. In addition, with one-pot LAMP-CRISPR/Cas12b detection, 5 of 66 fresh pork samples, 1 of 20 ready-to-eat food samples, and 2 of 24 raw milk samples tested positive for L. monocytogenes, in agreement with the results obtained through a culture based standard method. Thus, this study established one-pot LAMP-CRISPR/Cas12b and LAMP-CRISPR/Cas12b-LFA assays for rapid, visual detection of L. monocytogenes in food samples.
2026-04-01Bioactive Materials
Chiral metal nanozyme-enabled SOD2 activation and siRNA delivery cooperatively mitigating chronic heart failure
Article
作者: Wang, Zekun ; Hu, Yanyu ; Sun, Dongdong ; Fu, Xiaoyan ; Fan, Cundong ; Song, Qile ; Wang, Yifan ; Zhang, Ruofei ; Fan, Kelong ; Chen, Mei
Doxorubicin (DOX) treatment can lead to intracellular iron overload in cardiomyocytes, triggering excessive generation of reactive oxygen species (ROS) and resulting in cardiotoxicity. Superoxide dismutase (SOD) effectively scavenges ROS, and its catalytic activity depends on the binding of metal ions at its active site. Therefore, enhancing the activity of metal-dependent SOD represents a promising strategy to inhibit ferroptosis in cardiomyocytes and alleviate DOX-induced chronic heart failure. In this study, we constructed a biomimetic chiral MnO2 nanozyme co-modified with macrophage and platelet membranes (D/L-MnO2@MM), enabling precise targeting of DOX-injured myocardial tissues. This nanozyme exhibited potent catalase-like and SOD-like activities, efficiently eliminating excessive local hydrogen peroxide (H2O2) and superoxide anions (O2 •-). Notably, the D-enantiomeric nanozyme (D-MnO2@MM) significantly enhanced endogenous SOD2 activity via Mn2+ ion release, thereby suppressing the accumulation of lipid peroxides. Furthermore, based on transcriptomic and proteomic analyses, we designed an siRNA targeting the Hmox1 gene (siHmox1) and successfully loaded it onto the nanozyme platform (siHmox1@D/L-MnO2@MM). Both in vitro and in vivo experiments confirmed that the dual mechanism, SOD2 activation and Hmox1 silencing, effectively restored mitochondrial function, attenuated ferroptosis, and significantly improved cardiac function in a rat model of chronic heart failure. Collectively, this study proposes a novel ferroptosis-targeted therapeutic strategy based on a biomimetic chiral nanozyme, offering new insights and promising therapeutic potential for the treatment of DOX-induced cardiotoxicity.
2026-03-01Journal of Environmental Sciences
Simultaneous removal of manganese and nitrate by manganese redox driven moving bed biofilm reactor: Characteristic, biological community and mechanism
Article
作者: Zhou, Yiyang ; Li, Tenghao ; Pan, Dandan ; Shao, Sicheng ; Wu, Xiangwei ; Shen, Weiwu
This study investigated the effects of different manganese forms (MnCl2 and MnO2) on the nitrogen and phosphorus removal performance of moving bed biofilm reactor (MBBR). Compared to the control without manganese, the addition of MnCl2 and MnO2 increased NO3--N removal efficiency by 11.47 % and 9.54 %, and total nitrogen (TN) removal efficiency by 17.91 % and 15.45 %, respectively. The average accumulation of NO2--N decreased from 3.02 to 0.04 mg/L and 0.18 mg/L, respectively. The manganese redox system induced by MnCl2 enhanced total phosephorus (TP) removal efficiency by approximately 3.5 times, while MnO2 reduced TP removal efficiency by 2.94 %. After discontinuing MnCl2 and MnO2 supplementation, denitrification efficiency significantly declined, and Mn(II) reduced by BioMnOx could not sustain the manganese cycling process long-term. Extracellular polymeric substances (EPS) analysis revealed that MnCl2 and MnO2 stimulated the production of uronic acids, amide III, and secondary amides in proteins. High-throughput sequencing indicated that Proteobacteria, Bacteroidetes, Chloroflexi, and Acidobacteria were the dominant phyla involved in denitrification, but different manganese sources altered the microbial community composition. The relative abundance of Proteobacteria generally decreased, while Bacteroidetes increased by 16.29 % and 4.14 % with MnCl2 and MnO2. MnCl2 was more conducive to the Bacteroidetes growth. This study provides a practical framework for applying manganese-enhanced MBBR system in wastewater treatment plants to improve nitrogen removal efficiency and operational stability.
100 项与 安徽农业大学 相关的药物交易
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100 项与 安徽农业大学 相关的转化医学
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