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Clinical Evaluation of DAILIES TOTAL 1 Multifocal Compared to 1-Day Acuvue Moist Multifocal in a Japanese Population - Clinical Evaluation of DAILIES TOTAL 1 Multifocal Compared to 1-Day Acuvue Moist Multifocal in a Japanese Population

开始日期2017-12-20

申办/合作机构

Alcon Japan Ltd.

JPRN-UMIN000021976 / Completed

Clinical evaluation of DAILIES TOTAL 1 performance in a Japanese population. - Clinical evaluation of DAILIES TOTAL 1 performance in a Japanese population.

开始日期2016-04-25

申办/合作机构

Alcon Japan Ltd.

JPRN-UMIN000005931 / CompletedN/A

Clinical evaluation of 0.1% olopatadine hydrochloride ophthalmic solution in pediatric patients - Clinical evaluation of 0.1% olopatadine hydrochloride ophthalmic solution in pediatric patients

开始日期2010-03-01

申办/合作机构

Alcon Japan Ltd.

100 项与 Alcon Japan Ltd. 相关的临床结果

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0 项与 Alcon Japan Ltd. 相关的专利（医药）

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项与 Alcon Japan Ltd. 相关的文献（医药）

2021-03-31·Journal of Ophthalmology4区 · 医学

Experimental Study on Delivery Performance of an Automated Preloaded Intraocular Lens Injector System for Corneal and Sclerocorneal Incisions

4区 · 医学

ArticleOA

作者: Sasaki, Noriyuki ; Oshika, Tetsuro

Purpose. To evaluate delivery performance of an automated preloaded intraocular lens (IOL) injector systems (AutonoMe) in the porcine eyes. Methods. In the freshly excised porcine eyes, lens removal and IOL implantation were performed. There were 4 groups (10 eyes per group) with different incision site and size: 2.2-mm and 2.4-mm corneal incisions and 2.2-mm and 2.4-mm sclerocorneal incisions. Delivery performance and wound enlargement of AutonoMe were analyzed and compared with those of iTec and iSert from a previous study. Results. There were a few minor troubles associated with AutonoMe, such as overriding plunger within cartridge and trapped trailing haptic during IOL insertion, but the incidence was low. Other interactions were not observed, such as IOL adherence to plunger, sudden ejection of IOL, intrawound lens manipulation, IOL behavior, and gross damage to IOL. AutonoMe caused significantly less wound enlargement for both corneal and sclerocorneal incisions than other injector devices. Wound enlargement by using AutonoMe was significantly smaller with 2.4-mm corneal incision than with 2.2-mm corneal incision, but the final incision size was still smaller with 2.2-mm corneal incision. For sclerocorneal incisions, the amount of wound stretch was not different between 2.2 and 2.4 mm incisions. Conclusion. The wound enlargement caused by the automated preloaded insertion system, AutonoMe, was smaller than that of other preloaded injectors for both corneal and sclerocorneal incisions. There were a few minor technical events during IOL insertion, but the overall incidence was low.

2020-03-01·Japanese Journal of Ophthalmology3区 · 医学

Results of a clinical evaluation of a trifocal intraocular lens in Japan

3区 · 医学

Article

作者: Bissen-Miyajima, Hiroko ; Hayashi, Ken ; Sasaki, Noriyuki ; Igarashi, Chizuka ; Ota, Yuka

PURPOSETo evaluate the effectiveness and safety of a new trifocal intraocular lens (IOL) after cataract removal in patients living in Japan.STUDY DESIGNProspective multicenter clinical study.METHODSOne hundred and thirty-five eyes of 68 patients (19 men, 49 women; mean age, 66.3 ± 7.4 years) were followed for 6 months. Trifocal IOLs with focal points at near, intermediate, and distance were implanted bilaterally in eyes with less than 1 diopter of corneal astigmatism. The visual acuity (VA) at distance, 60 and 40 centimeters (cm), and contrast sensitivities were measured. Patients completed quality-of-life questionnaires preoperatively and postoperatively.RESULTSThe mean bilateral logarithm of the minimum angle of resolution VA at 5 meters (m), 60 cm, and 40 cm were, respectively: uncorrected, - 0.104 ± 0.095, - 0.065 ± 0.111, and - 0.042 ± 0.105; and distance-corrected, - 0.197 ± 0.076, - 0.112 ± 0.111, and - 0.073 ± 0.111. The contrast sensitivities at distance and near were within the normal range at all spatial frequencies under photopic conditions. Patients reported complete spectacle independence in 75.0% of cases. Total use of spectacles was reported by 1.5% and partial by 20.6%; the purpose of spectacle use was primarily for near visual tasks. Mild-to-moderate glare was reported by 65.7% of patients and halos by 70.1%; only 1.5% of subjects reported severe glare and halos.CONCLUSIONSThis new trifocal IOL provides equally good uncorrected VAs at distance, intermediate, and near, and decreases spectacle dependence in daily life. Patients frequently report mild-to-moderate glare and halos, and patients should be informed about these before implantation.

2015-01-01·Journal of Toxicologic Pathology4区 · 医学

Characteristics of structures and lesions of the eye in laboratory animals used in toxicity studies

4区 · 医学

Review

作者: Shibuya, Kazumoto ; Tomohiro, Masayuki ; Sasaki, Shoji ; Otake, Seiji

Histopathology of the eye is an essential part of ocular toxicity evaluation. There are structural variations of the eye among several laboratory animals commonly used in toxicity studies, and many cases of ocular lesions in these animals are related to anatomical and physiological characteristics of the eye. Since albino rats have no melanin in the eye, findings of the fundus can be observed clearly by ophthalmoscopy. Retinal atrophy is observed as a hyper-reflective lesion in the fundus and is usually observed as degeneration of the retina in histopathology. Albino rats are sensitive to light, and light-induced retinal degeneration is commonly observed because there is no melanin in the eye. Therefore, it is important to differentiate the causes of retinal degeneration because the lesion occurs spontaneously and is induced by several drugs or by lighting. In dogs, the tapetum lucidum, a multilayered reflective tissue of the choroid, is one of unique structures of the eye. Since tapetal cells contain reflecting crystals in which a high level of zinc has been demonstrated chemically, drug-induced tapetum degeneration is possibly related to zinc chelation. The eye of the monkey has a macula similar to that of humans. The macula consists only of cones with a high density, and light falls directly on the macula that plays an important role in visual acuity. Macular degeneration occurring in monkeys resembles histopathologically that of humans. Hence, the eye of the monkey is a suitable model to investigate macular degeneration and to assess drug-induced macular lesions.

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