预约演示
更新于：2026-05-11
北海道公立大学法人札幌医科大学
更新于：2026-05-11
概览
标签
肿瘤
单链Fv片段抗体
双特异性T细胞结合器
疾病领域得分
一眼洞穿机构专注的疾病领域
技术平台
公司药物应用最多的技术
靶点
公司最常开发的靶点
关联
靶点 |
作用机制 |
在研机构 |
原研机构 |
在研适应症 |
非在研适应症 |
最高研发阶段 |
首次获批国家/地区 |
首次获批日期 |
JPRN-UMIN000060544
Evaluation of the Efficacy of a Thirst Care Bundle for Tracheally Intubated Patients - Evaluation of the Efficacy of a Thirst Care Bundle for Tracheally Intubated Patients
JPRN-UMIN000060204
A Study on the Effects and Efficacy of Brainspotting Psychotherapy for Cancer Patients and Patients with Depression - Research on the Effects and Efficacy of Brainspotting
JPRN-UMIN000060711
Standardization of sexual health education in patients with pulmonary hypertension - Standardization of sexual health education in patients with pulmonary hypertension
100 项与 北海道公立大学法人札幌医科大学 相关的临床结果
登录后查看更多信息
登录后查看更多信息
2026-04-01General Thoracic and Cardiovascular Surgery
Left atrial appendage blood flow analysis using four-dimensional flow magnetic resonance imaging
Article
作者: Nakazawa, Junji ; Tsushima, Shingo ; Arihara, Ayaka ; Ohkawa, Akihito ; Kawaharada, Nobuyoshi ; Nakajima, Tomohiro ; Yasuda, Naomi ; Hosaka, Itaru ; Iba, Yutaka ; Shibata, Tsuyoshi ; Nakanishi, Mitsuhiro ; Tachibana, Kazutoshi
OBJECTIVE:
Thrombus formation in atrial fibrillation is caused by blood flow stagnation within the left atrial appendage (LAA). It is believed that blood flow tends to stagnate within the LAA even in patients with sinus rhythm and high risk of stroke. This study evaluated blood flow within the LAA using four-dimensional flow magnetic resonance imaging among patients stratified by the congestive heart failure, hypertension, age, diabetes mellitus, prior stroke, vascular disease, age, sex category (CHA2DS2-VASc) score.
METHODS:
Ninety-eight participants with sinus rhythm (70 patients, 28 controls) underwent non-contrast four-dimensional flow magnetic resonance imaging. Participants were divided into low- and high-risk groups (CHA2DS2-VASc scores 0-2 and 3-9, respectively. Blood flow parameters, including the blood flow volume in the basal, middle, and top segments of the LAA, were analyzed and compared between groups.
RESULTS:
The blood flow volume was significantly reduced in the top segment of the LAA in the high-risk group (low-risk: 3.13 ± 1.07 mL/cm2 vs. high-risk: 2.54 ± 0.96 mL/cm2, p = 0.006). However, the blood flow volume in the basal and middle segments did not differ significantly between the two groups (basal segment, p = 0.14; middle segment, p = 0.44). In addition, larger LAA volumes (EDV, ESV, and mean volume) were associated with reduced top-segment flow, but correlations with intra-LAA flow were not statistically significant.
CONCLUSIONS:
In patients with high CHA2DS2-VASc scores, blood flow stagnation can occur in the LAA top segment even in the presence of sinus rhythm. Establishing blood flow-based criteria may enhance the potential applications of LAA closure to prevent stroke.
2026-04-01AMERICAN JOURNAL OF TROPICAL MEDICINE AND HYGIENE
Trichinellosis after Raw Bear Eyeball Consumption
Article
作者: Nomura, Kazuhito ; Jinno, Atsushi ; Zhiliang, Wu ; Shiratori, Masanori ; Nagahata, Ken ; Tsuji, Yoshihisa ; Mihara, Hiroshi ; Yoichi, Maekawa
ABSTRACT.:
Trichinellosis, a zoonotic parasitic disease, is usually transmitted through raw or undercooked muscle tissue. We report a 25-year-old hunter from Hokkaido, Japan, who acquired trichinellosis by consuming a raw bear eyeball, a tissue previously presumed to be parasite-free. He developed fatigue and rash within 3 days, followed by fever and myalgia 9 days after consumption. Serology confirmed trichinellosis, and treatment with albendazole led to full recovery. Among five hunters who consumed meat from the same bear, only the two who ate raw eyeballs developed the disease, whereas those who ate only cooked meat remained asymptomatic. This appears to be the first report of trichinellosis linked to raw bear eyeballs. Clinicians and public health practitioners should be aware that any uncooked tissue may carry an infection risk. These findings underscore the need for vigilance against unconventional transmission routes and culturally sensitive education for accurate diagnosis and prevention.
2026-04-01Cancer Epidemiology
The International Classification of Diseases for Oncology, 4th Edition (ICD-O-4): An overview
Review
作者: Cree, Ian A ; Wijesinghe, Harshima D ; Levy, Gabrielle Goldman ; Lokuhetty, Dilani ; Watanabe, Reiko ; Jakob, Robert ; Puspanathan, Pavitratha ; Krpelanova, Eva ; Rous, Brian ; Znaor, Ariana ; Bray, Freddie
BACKGROUND:
The International Classification of Diseases for Oncology (ICD-O) was specifically developed for coding tumours according to their site of origin (topography), microscopic appearance or histology, behaviour and grade (morphology), and is optimal for use in cancer registries. The fourth edition of the ICD-O (ICD-O-4) aims to provide an improved structure of unique codes to existent and newly defined tumour entities and has been harmonised with the International Classification of Diseases 11th Edition (ICD-11).
METHODS:
Based on an International Association of Cancer Registries (IACR) survey of cancer registries, over 90 % of the respondents (250 of 276) agreed to an update of ICD-O-3.2 morphology by the addition of a fifth digit to the existing four-digit histology code. Following the 5th Edition of the WHO Classification of Tumours (WCT), a beta version of ICD-O-4 was developed and disseminated for open consultation by the International Agency on Research for Cancer (IARC) on the WCT website.
RESULTS:
Following closure of the consultation period, the ICD-O-4 codes were finalized. The main changes in comparison to ICD-O-3.2 include the addition of a 5th alphanumeric digit to the histology code, changes in the first four digits of histology codes, changes of behaviour codes (e.g. pituitary adenoma code changed from /1 to /3), a new topography code for gastroesophageal junction (C16.7), detailed codes for extrahepatic bile ducts (C24.2, C24.3) and cystic duct (C24.4), change of the code for anal skin cancer from skin to anus (C44.5 to C21.3) and an optional additional digit in the topography code.
CONCLUSION:
ICD-O-4 is compiled in consultation with pathologists, epidemiologists, public health researchers as well as the cancer registry community. The five-digit histology codes enable a hierarchical and detailed coding of tumours, while the new topography and behaviour codes reflect the evidence base on tumour aetiology, stage and behaviour.
2026-04-23
2026-04-22
100 项与 北海道公立大学法人札幌医科大学 相关的药物交易
登录后查看更多信息
100 项与 北海道公立大学法人札幌医科大学 相关的转化医学
登录后查看更多信息
组织架构
使用我们的机构树数据加速您的研究。
登录
或
管线布局
2026年05月21日管线快照
管线布局中药物为当前组织机构及其子机构作为药物机构进行统计，早期临床1期并入临床1期，临床1/2期并入临床2期，临床2/3期并入临床3期
临床前
1
4
其他
登录后查看更多信息
当前项目
登录后查看更多信息
药物交易
使用我们的药物交易数据加速您的研究。
登录
或
转化医学
使用我们的转化医学数据加速您的研究。
登录
或
营收
使用 Synapse 探索超过 36 万个组织的财务状况。
登录
或
科研基金(NIH)
访问超过 200 万项资助和基金信息，以提升您的研究之旅。
登录
或
投资
深入了解从初创企业到成熟企业的最新公司投资动态。
登录
或
融资
发掘融资趋势以验证和推进您的投资机会。
登录
或
生物医药百科问答
全新生物医药AI Agent 覆盖科研全链路，让突破性发现快人一步
立即开始免费试用!
智慧芽新药情报库是智慧芽专为生命科学人士构建的基于AI的创新药情报平台，助您全方位提升您的研发与决策效率。
立即开始数据试用!
智慧芽新药库数据也通过智慧芽数据服务平台，以API或者数据包形式对外开放，助您更加充分利用智慧芽新药情报信息。
生物序列数据库
生物药研发创新
免费使用
化学结构数据库
小分子化药研发创新
免费使用