Patients with COPD benefit from pulmonary rehabilitation (PR), but a ceiling effect of performance (ie. absence of additional exercise tolerance increase) is observed in 80% of patients from only 20 sessions. An imbalance between intensity, duration and frequency of PR sessions, leading to fatigue development in the course of the PR, could explain this ceiling effect. However, previous studies having evaluated the impact of a PR program on fatigue scores reported either a decrease or no changing, but never an increase. To date, no study has evaluated intermediate variations of fatigue score during a PR program, but were limited to a pre-post PR assessment. Therefore, fatigue fluctuations during PR are unknown. Furthermore, most studies had only unidimensional fatigue assessment. Since fatigue is a multifactorial and a multidimensional process, it cannot be accurately estimated through a unique assessment. Given that most of COPD patients do not increase their exercise tolerance from 20 PR sessions, the investigators hypothesize a significant increase of multidimensional fatigue score between the 1st and the 20th PR session during an inpatient rehabilitation program lasting 4 weeks (40 sessions).

开始日期2020-02-15

申办/合作机构

5 Santé SAS

NCT04010825

/ CompletedN/A

Impact of Hypnosis Intervention Focused on the Emotional Dimension of Dyspnea on the Maintenance of Benefits for Patients With COPD After a Pulmonary Rehabilitation: A Multicenter Randomized Controlled Clinical Study

The purpose of the clinical study is to compare the effect of hypnosis intervention on the emotional dimension of the dyspnea during a pulmonary rehabilitation program to the pulmonary rehabilitation program alone. This study will determine if the hypnosis intervention will lead to better maintenance of benefits obtained than the original described method.

开始日期2019-10-25

申办/合作机构

5 Santé SAS

NCT03807258

/ CompletedN/A

Functional Implication of Corpus Callosum in Voluntary Strength in COPD Patients

Patients with COPD have lower capability of activating their muscles. At the cortical level, force production is not only controlled by contralateral primary motor cortex but also by ipsilateral motor cortex. The aim of this study is to determine whether ipsilateral areas are functionally impaired in COPD.

开始日期2018-10-20

申办/合作机构

5 Santé SAS

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项与 5 Santé SAS 相关的文献（医药）

2018-10-01·Journal of Sport and Health Science1区 · 医学

Intention and automaticity toward physical and sedentary screen-based leisure activities in adolescents: A profile perspective

1区 · 医学

ArticleOA

作者: Marchant, Gonzalo ; Boiché, Julie ; Chevance, Guillaume

PURPOSEPhysical activity (PA) and sedentary behavior (SB) are increasingly considered independent health behaviors. Additionally, current research suggests that both controlled and automatic determinants account for their adoption. The purpose of this article was to identify intention-automaticity profiles toward PA and screen-based SB and to examine how those profiles are associated with different behavioral patterns.METHODTwo cross-sectional studies based on self-report questionnaires were conducted with French high school students (Study 1: n = 198; Study 2: n = 185).RESULTSIn all, 4 distinct motivational profiles appeared. The first 3 clusters emerged in both studies: "PA" (high levels of automaticity and intention for PA, low levels of automaticity and intention for screen-based SB); "screen" (high levels of automaticity and intention for screen-based SB, low levels of automaticity and intention for PA), and "mixed" (high levels of all variables), whereas the fourth cluster was observed only in Study 2: "high control" (below-mean levels of automaticity, high levels of intention toward both PA and screen-based SB). Adolescents with a screen profile displayed the least healthy behavioral pattern, whereas those in the PA profile demonstrated the most favorable behaviors.CONCLUSIONFuture research is needed to extend these results to other populations using complementary assessment methods of automatic psychological processes and PA and SB behaviors.

2016-09-01·1.2 Rehabilitation and Chronic Care

LATE-BREAKING ABSTRACT: Antioxidant supplementation in chronic obstructive pulmonary disease (COPD): A relevant way to optimize pulmonary rehabilitation effects

作者: Joël Pincemail ; Nelly Héraud ; Christian Préfaut ; Jacques Mercier ; François Bughin ; Philippe De Rigal ; Pascal Pomiès ; Dalila Laoudj-Chenivesse ; Maurice Hayot ; Fares Gouzi ; Marine Blaquière ; Magali Poulain ; Jonathan Maury ; Nicolas Molinari

In COPD patients oxidative stress (OS) is a limiting factor of exercise training effects on muscle impairment during pulmonary rehabilitation (PR). Antioxidant supplementation used during PR appeared inappropriate to cope with COPD-related antioxidant deficits. We therefore investigated whether exercise training PR, combined with non-pharmacological antioxidant supplementation (vitamins C and E, zinc, selenium), would have beneficial effects on muscle impairment and exercise capacity. 58 stable COPD patients (61 years; FEV1: 59%predicted) referred for a 4-week PR program, were recruited in a double-blind randomized, placebo-controlled clinical trial. Primary outcome was change in quadriceps endurance (Qend). Secondary outcomes were: quadriceps maximal voluntary contraction (QMVC), exercise capacity (maximal oxygen uptake (Vo 2sl ), systemic OS markers and muscle fiber cross sectional area (CSA). Qend was significantly increased in both COPD patient groups. QMVC and VO 2sl were improved (+9 and +16%, respectively) exclusively in “PR+antioxidant” group (p=0.01 and p In conclusion, this study showed that antioxidant supplementation combining vitamin C, E, zinc and selenium, improves the PR effects on QMVC, Vo 2sl and muscle fiber CSA by enhancing antioxidant capacity of COPD patients.

项与 5 Santé SAS 相关的新闻（医药）

2020-02-24

·SYNAPSE

Korian announces the acquisition of 5 Santé Group, a key player in the treatment of chronic diseases

Korian announces its acquisition of 5 Santé, a rapidly developing French group that specialises in the treatment of chronic diseases from Catherine Miffre, its founder, and investment fund Parquest Capital. 5 Santé, which has an excellent reputation in the rehabilitation of patients suffering from respiratory diseases, offers customised care pathways to patients who live at home and visit its clinics for pre-scheduled stays. The group owns six post-acute and rehabilitation care clinics located in the French regions of Auvergne-Rhône-Alpes and Occitanie. Founder and CEO Catherine Miffre and her management are joining Korian’s teams to pursue the development of 5 Santé. “We are pleased to welcome 5 Santé’s medical teams to the Group, together with its dedicated team of researchers whose unique expertise, strengthens our innovation capabilities for the development of future projects. With this acquisition, Korian moves a step further towards specialising its services, in order to offer personalised support, adapted to the patient’s needs in the areas where the Group operates.”, Nicolas Merigot, France Healthcare Division Executive VP. “5 Santé Group’s incorporation into the Korian group will strengthen our expertise in the treatment of chronic diseases. It will also reinforce innovation as part of the concept developed by our researchers to allow its application to all chronic pathologies and to accelerate its progress towards a pathway approach dedicated to improving the quality of life of our patients.”, Catherine Miffre, CEO of 5 Santé Group.

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