Article
作者: Burling, Keith ; Altinok, Selin ; Sosa, Julio ; Rodríguez-Lopez, María ; Valipour Kahrood, Hossein ; French, Alison ; Eisch, Amelia J ; Li, Yinghui ; Galazka, Jonathan M ; Muratani, Masafumi ; Broni-Tabi, Jessica ; Zhang, Haijian ; Schisler, Jonathan C ; da Silveira, Willian A ; Overbey, Eliah ; Gordon, Peter ; Yamamoto, Masayuki ; Nicod, Jérôme ; Mason, Christopher E ; Kiffer, Frederico C ; Al-Maadheed, Mohammed ; Li, Zhongwang ; Zwart, Sara R ; Meydan, Cem ; Allen, Noah ; Karouia, Fathi ; A C Almeida, Eduardo ; Shiba, Dai ; Vaughan, Michael B ; Siew, Keith ; Slawinski, Hubert ; Rodriques, Samuel ; Lee, Han-Chung ; Faridi, Pouya ; Boyko, Valery ; Lucarelli, Nicholas ; O'Shaughnessy, Kevin M ; Wan, Elizabeth R ; Oliveira, Lorraine Christine De ; Degoricija, Lovorka ; Saravia-Butler, Amanda M ; Smith, Scott M ; Patel, Vaksha ; Nelson, Charlotte ; Arif, Shehbeel ; Uruno, Akira ; Oswalt, Leah ; Sadeghi-Alavijeh, Omid ; Kim, JangKeun ; Finch, Rebecca ; Patras, Laura Ioana ; Roufosse, Candice ; McCann, Colleen M ; Border, Samuel ; Barker, Peter ; Steele, Joel Ricky ; Blaber, Elizabeth ; Grillo, Alessandra ; Yasmin ; Houerbi, Nadia ; Snell, Daniel ; Foox, Jonathan ; Sarder, Pinaki ; Gebre, Samrawit ; D'Ambrosio, Viola ; Tabetah, Marshall ; Sanders, Lauren M ; Sanchez-Hodge, Rebekah ; Naglah, Ahmed ; Cheshire, Chris ; Yun, Sanghee ; Cheng-Campbell, Margareth ; Schweickart, Annalise ; Al-Jaber, Maneera Yousef ; Dai, Zhongquan ; Schittenhelm, Ralf Bernd ; Bah, Nourdine ; Walker-Samuel, Simon ; Campbell, Robert A A ; Matei, Irina ; Colón, Lorianna M ; Mohamed-Alis, Vidya ; Choy Lim Kam Sian, Terry Chin ; Beheshti, Afshin ; Paul, Anindya S ; Yang, Xiaoping ; Tanuwidjaya, Erwin ; Baranzini, Sergio ; Afsari, Fatemeh ; Figg, Nichola ; Mimar, Sayat ; Nestler, Kevin A ; Fazelinia, Hossein ; Zhong, Chutong ; Cubitt, Laura ; Costes, Sylvain V ; Godovac-Zimmermann, Jasminka ; Marullo, Anthony L ; Walsh, Stephen B ; Lynham, Steven ; Lai Polo, San-Huei ; Scott, Ryan T ; Klosinska, Aleksandra S ; Kubik, Angela ; Brown, Amanda L
Missions into Deep Space are planned this decade. Yet the health consequences of exposure to microgravity and galactic cosmic radiation (GCR) over years-long missions on indispensable visceral organs such as the kidney are largely unexplored. We performed biomolecular (epigenomic, transcriptomic, proteomic, epiproteomic, metabolomic, metagenomic), clinical chemistry (electrolytes, endocrinology, biochemistry) and morphometry (histology, 3D imaging, miRNA-ISH, tissue weights) analyses using samples and datasets available from 11 spaceflight-exposed mouse and 5 human, 1 simulated microgravity rat and 4 simulated GCR-exposed mouse missions. We found that spaceflight induces: 1) renal transporter dephosphorylation which may indicate astronauts' increased risk of nephrolithiasis is in part a primary renal phenomenon rather than solely a secondary consequence of bone loss; 2) remodelling of the nephron that results in expansion of distal convoluted tubule size but loss of overall tubule density; 3) renal damage and dysfunction when exposed to a Mars roundtrip dose-equivalent of simulated GCR.