Surgical and Anesthesiological-resuscitation Aspects of Therapeutic Tactics for Thrombotic and Hemorrhagic Complications in Patients With the New Coronavirus Infection COVID-19

The nature of the planned study:
The topic is of an applied nature and is aimed at improving the results of comprehensive treatment of patients with COVID-19, the course of whose disease was complicated by thrombotic or hemorrhagic catastrophes.
It is planned to analyze the results of treatment of this category of patients based on the work of several centers that provided surgical care to patients with COVID-19 during the pandemic (8 cities).
As a result of the analysis, it is planned to develop algorithms for the prevention and treatment of thrombotic and hemorrhagic complications in patients with COVID-19.
The proposed study will be multicenter, cohort, retrospective.
The purpose of the study:
Improvement of treatment results in COVID-19 patients with thrombotic or hemorrhagic complications
Scientific novelty:
For the first time, as a result of a multicenter study, it is expected to identify the most effective approach to the treatment and prevention of thrombotic and hemorrhagic complications in patients with COVID-19.
For the first time, it is planned to develop and put into practice algorithms for the application of the most effective methods of treatment and prevention of thrombohemorrhagic complications of COVID-19.

开始日期2024-01-12

申办/合作机构

Volgograd State Medical University

NCT04244435 / Unknown status早期临床1期IIT

Consequences of Using Thoracic Epidural Analgesia for Coronary Artery Bypass Grafting

Investigators plan to study the effect of thoracic epidural analgesia on postoperative parameters (complication rate, duration of hospitalization, mortality, etc.) of coronary artery bypass grafting.

开始日期2020-02-01

申办/合作机构

Volgograd State Medical University

NCT04023565 / Unknown status临床4期IIT

Open-Label Non-Comparative Study of the Effects of a Combination Antihypertensive Treatment With Moxonidine + Perindopril in Hypertensive Patients With Metabolic Syndrome

The aim of study is to assess the angioprotective effects of antihypertensive combination therapy with perindopril 10 mg and moxonidine 0.4-0.6 mg in patients with arterial hypertension, metabolic syndrome, and obesity, who had Pulse Wave Velocity (PWV) > 10 m/s on the previously administered two-component combination antihypertensive therapy.
Open-label non-comparative prospective study for 24 week for each patient.

开始日期2019-03-11

申办/合作机构

Volgograd State Medical University

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156

项与 Volgograd State Medical University 相关的文献（医药）

2024-09-29·Ulyanovsk Medico-biological Journal

ROLE OF THE EMOTIONAL-MOTIVATIONAL COMPONENT IN THE DYNAMICS OF CNS FUNCTIONAL CAPACITY IN SECONDARY SCHOOL STUDENTS

作者: Antonova, Alena Anatol'evna ; Sibiryakova, Natal'ya Vladimirovna ; Yamanova, Galina Aleksandrovna ; Kudrin, Rodion Aleksandrovich

The main clinical syndromes of chronic cerebral ischemia (CCI) are impaired gait and balance disorders, High morbidity level among school children, which has been recorded over the past decade in our country, necessitates a review of the contributing causes, mechanisms and factors. Objective. The purpose of the study is to assess CNS functional capacity in secondary school students taking into account anxiety and the motivational component. Materials and Methods. The study enrolled 424 secondary school students aged 10–17, living in Astrakhan. Simple and complex visual-motor reaction test was carried out. To study personality traits, anxiety and motivation levels of the participants, the authors used Junior Eysenck Personality Questionnaire (JEPQ), School Anxiety Test (Phillips Test), and Spielberg-Andreeva motivation questionnaire. Results. A significant decrease in the level of CNS functional capacity was noted when compared with the age norm. CNS functional level increases with age, while its values in the examined 12–13 and 14–15 year-old participants are below the average age ones. A decrease in the motivation level was revealed among the trial subjects. A positive attitude towards learning and effective motivation was revealed in 53.6 % of secondary school students aged 10–11; 38,6 % aged 12–13; 30,3 % aged 14–15 and 30 % aged 16–17. A high level of general anxiety was revealed in 40.9 % of secondary school students aged 10–11; 63.6 % aged 12–13; 12.8 % aged 14–15 and 6 % aged 16–17. Conclusion. The parameters of CNS functional capacity in most cases are characterized by below average values. The anxiety level significantly decreases with age, which indicates an adequate influence of learning environment on students. The highest anxiety level was revealed in the trial subjects aged 12–13. Motivation for learning decreases with age, which is probably due to psychological and motivational age-related changes in adolescence.

2024-09-29·Ulyanovsk Medico-biological Journal

CHARACTERISTICS OF SOMNOLOGICAL STATUS AND MELATONIN METABOLISM IN WOMEN IN CLIMACTERIC PERIOD WHO LIVED IN A WAR ZONE FOR A LONG TIME

作者: Zmienko, Vera Andreevna ; Zheleznyakova, Elena Vasil'evna ; Botasheva, Tat'yana Leonidovna ; Fabrikant, Il'ya Mikhaylovich ; Gorbaneva, Elena Petrovna ; Zavodnov, Oleg Pavlovich

The aim of the study is to examine the characteristics of somnological status, melatonin metabolism and perimenopause course in women of the Rostov region in comparison with women who lived in the war zone for a long time. Materials and Methods. The assessment of the somnological status included a questionnaire-based survey on sleep quality parameters, sleep apnea syndrome, daytime sleepiness (Epworth sleepiness scale) and a polysomnographic study. Enzyme immunoassay was used to determine the level of 6-sulfatoxymelatonin. The severity of the climacteric syndrome was established according to the Kupperman-Uvarova modified menopausal index. The authots examined 121 women aged 40–50: Group 1 consisted of 58 women living in the Rostov region for at least 10 years; Group 2 included 63 women who lived in the war zone in Donbass for at least 8–10 years. Statistical processing was used to calculate the median, interquantile range, Mann-Whitney and Wilcoxon criteria. Results. It was found that women who had lived in the war zone (Donetsk and Lugansk People's Republics) under chronic stress for a long time, had more pronounced somnological disorders, which caused a decrease in melatonin production and more severe climacteric disorders in comparison with women living in the Rostov Region. The most frequent symptoms of neurovegetative deviations were identified: fluctuating blood pressure, headaches before the menstruation, swelling, dry skin, sweating, increased excitability, hot flashes and sleep disorders. Conclusion. Long-term influence of stress-potentiating socially conditioned factors of the war zone causes dysfunctional deviations, decrease in melatonin level, neurovegetative, psychoemotional and endocrine-metabolic disorders that reduced the quality of life in perimenopausal women. Thus, it is desirable to develop effective preventive and corrective strategies for women of this age group.

2024-09-01·Journal of Hypertension

Association of 24-h central hemodynamics and stiffness with cardiovascular events and all-cause mortality. The VASOTENS Registry

Article

作者: Bulanova, Natalia ; Omboni, Stefano ; Paini, Anna ; Barin, Edward ; Arystan, Ayana ; Avolio, Alberto ; Cuffaro, Paula ; Gurevich, Alexandra ; Pereira, Telmo ; Derevyanchenko, Maria ; Statsenko, Mikhail E. ; Konradi, Alexandra ; Grigoricheva, Elena ; Bokusheva, Jamilya ; Tan, Isabella ; Butlin, Mark ; Alfie, Jose ; Muiesan, Maria Lorenza

Objectives:In hemodialysis patients, central hemodynamics, stiffness, and wave reflections assessed through ambulatory blood pressure monitoring (ABPM) showed superior prognostic value for cardiovascular (CV) events than peripheral blood pressures (BPs). No such evidence is available for lower-risk hypertensive patients.Methods:In 591 hypertensive patients (mean age 58 ± 14 years, 49% males), ambulatory brachial and central BP, pulse wave velocity (PWV), and augmentation index (AIx) were obtained with a validated upper arm cuff-based pulse wave analysis technology. Information on treatment for hypertension (73% of patients), dyslipidemia (27%), diabetes (8%), CV disease history (25%), was collected. Patients were censored for CV events or all-cause death over 4.2 years.Results:One hundred and four events (24 fatal) were recorded. Advanced age [hazard ratio and 95% confidence interval: 1.03 (1.01, 1.05), P = 0.0001], female sex [1.57 (1.05, 2.33), P = 0.027], CV disease [2.22 (1.50, 3.29), P = 0.0001], increased 24-h central pulse pressure (PP) [1.56 (1.05, 2.31), P = 0.027], PWV [1.59 (1.07, 2.36), P = 0.022], or AIx [1.59 (1.08, 2.36), P = 0.020] were significantly associated with a worse prognosis (univariate Cox regression analysis). The prognostic power of peripheral and central BPs was lower. However, PWV [1.02 (0.64, 1.63), P = 0.924], AIx [1.06 (0.66, 1.69), P = 0.823], and central PP [1.18 (0.76, 1.82), P = 0.471], were not significant predictors in multivariate analyses.Conclusions:In hypertensive patients, ambulatory central PP, PWV, and AIx are associated with an increased risk of CV morbidity and all-cause mortality. However, this association is not independent of other patient characteristics.

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