The aim of our study is to add to the literature the effect of the effectiveness of the physiotherapy and rehabilitation in the clinic, which will be applied to the patients after the osteochondral allograft transplantation operation, which is a current treatment approach applied after knee cartilage tissue damage, on the range of motion, functionality, pain and muscle strength of the patients during the recovery process. The clinical importance of our aim is that it will have the potential to guide health professionals in determining the appropriate treatment approach in order to reveal the best results that can be obtained due to the lack of many studies in the literature on the treatment of patients after osteochondral allograft surgery.

开始日期2024-10-09

申办/合作机构

Yeditepe University

NCT06326177 / Enrolling by invitationN/AIIT

Investigating Association Between Spine Posture, Spine Movement, Scapular Dyskinesia, Isometric and Eccentric Shoulder Strength and Core Muscle Endurance in Competitive Swimmers

The aim of this observational study is to investigate relationship between cervical, thoracic, lumbar and thoracolumbar spine posture, spine movement, isometric and eccentric shoulder strength, scapular dyskinesis and core muscle endurance in healthy competitive young swimmers in comparison with healthy recreational swimmers. The main question is whether spine posture affects spine movement, shoulder strength, scapular dyskinesia and core endurance. Participants will asked to complete a warm up period, after that spine posture, spine movement, scapular dyskinesia, shoulder strength and core endurance will be assessed by examiner. Researchers will compare competitive swimmer group and recreational swimmer group. Additionally correlation between spine posture, spine movement, scapular dyskinesia, shoulder strength and core muscle endurance will be investigated in competitive swimmer group. Aim of the study is to determine whether posture have any effect upon these parameters.

开始日期2024-08-10

申办/合作机构

Yeditepe University

NCT06436066 / RecruitingN/AIIT

Effect of Self-Acupressure Application on Peripheral Neuropathic Pain and HbA1c in Patients With Type 2 Diabetes

Aim: This study was conducted to examine the effect of self-applied acupressure on HbA1c and peripheral neuropathic pain in patients diagnosed with type 2 diabetes.
Background: Acupressure is an effective method for relieving pain, and this effectiveness is explained by the gate control theory and endorphin theory. There is only one study in the literature showing that acupressure reduces diabetic neuropathic pain. However, in this study, acupressure was performed by a trained health professional, not by the patient himself. Measurement of glycosylated hemoglobin (HbA1c) level is one of the standard methods for long-term management of diabetes and indicates the average blood glucose concentration over a three-month period. As a result of a meta-analysis study conducted in 2023, it was reported that acupressure significantly reduced the HbA1c level.
Design: This study was designed as a randomized controlled and experimental type study.
Methods: The study is conducted with patients with type 2 diabetes who are followed in the diabetes outpatient clinic of a training and research hospital between May-November 2024. There are 2 arms in the study. The study is conducted with a total of 60 patients, 30 in the control group and 30 in the intervention group. Data collection tools are "Patient Information Form", "Neuropathic Pain Questionnaire - DN4", "Neuropathic Pain Questionnaire - Short Form" and "Self-Acupressure - Satisfaction Evaluation Form with Visual Analogue Scale". While patients in the control group continue to receive routine care, patients in the intervention group are given self-acupressure training. Patients who receive training perform acupressure on their own 3 days a week for 3 months and record it on the follow-up form.

开始日期2024-07-25

申办/合作机构

Yeditepe University

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5,545

项与 Yeditepe University 相关的文献（医药）

2024-12-01·Molecular Biology Reports

Extracellular vesicles derived from human foreskin cells (hFS-Exo) accelerate cell migration and angiogenesis through MAPK pathway: an in vitro study

Article

作者: Öztürkoğlu, Dilek ; Şahin, Fikrettin ; Sağraç, Derya ; Aydın, Safa ; Kırbaş, Oğuz Kaan

BACKGROUNDWound healing is one of the important processes in the body. Attempts to create new drugs are of interest due to the side effects of natural and chemical wound healing compounds. To overcome this obstacle, stem cells have been used as healing agents. However, both difficulties in collection and risks such as rejection and teratoma in the recipient body have limited the use of stem cells, directly. Since the potential content of the stem cells can be transferred to the recipient cells by vesicles, small extracellular vesicles have recently become prominent agents.METHODS AND RESULTSThe wound-healing effect of extracellular vesicles derived from foreskin cells was investigated in both keratinocyte and endothelial cells. Migration assay, RT-PCR, Col1a1 ELISA and Western Blot experiments were utilized to reveal healing effect of EVs and its possible molecular pathways. EV-treated groups exhibited more proliferative, invasive, and migrative characteristics. When comparing to the control group, new vessel formation was induced in EV groups. An increase in gene levels of growth factors related to wound healing and change in the mitogen-activated protein kinase (MAPK) signaling pathway proteins in EV-treated groups were determined. Possible molecular mechanisms underlying cell movements were associated with the MAPK pathway. It was found that human foreskin cell EVs (hFS-Exo) may have a potential to heal wounds in a short period of time by triggering the MAPK pathway.CONCLUSIONShFS-Exo could be a new promising wound healing agent in the future.

2024-12-01·Molecular Biology Reports

Conditioned medium of induced pluripotent stem cell derived neuromesodermal progenitors enhances cell migration in vitro

Article

作者: Okumuş, Ezgi Bulut ; Turhan, Selinay Şenkal ; Doğan, Ayşegül

BACKGROUNDIdentification of novel cell-based therapy sources has been of great interest in recent years to provide alternative and available therapy options in clinics. Conditioned medium (CM) can be a valuable supply for growth factors, cytokines and chemokines as a source of stem cell secretome. Exploring the role of new CM sources for tissue regeneration might be a promising approach for therapeutic purposes.METHODS AND RESULTSIn the current study, neuromesodermal progenitors (NMPs) derived from induced pluripotent stem cells (iPSCs) were used to collect CM. Fibroblast derived iPSCs were successfully differentiated into NMPs and NMPs were characterized by double positive T/Bra and Sox2 staining. CM was collected from NMPs, and the content was characterized by membrane analysis. In vitro wound healing assay was used as a model system to observe potential activity of CM on cell migration. Fibroblasts, keratinocytes and endothelial cells were used to evaluate the effect of NMP-derived CM (NMP-CM) on cell migration in vitro. Several important proteins related to wound healing such as ANGPT 1, ANGPT 2, MCP-1, PDGF-AA, SDF-1α, TIMP-1 and TIMP-2 were increased in NMP-CM. NMP-CM increased cell proliferation and migration in vitro.CONCLUSIONSIn vitro data obtained from three distinct cell types suggest a promising role of NMP-CM on cell migration. NMP-CM can be used for wound management in the further future after detailed in vitro and in vivo research.

2024-12-01·Molecular Biology Reports

Azoxymethane-induced carcinogenesis-like model of mouse intestine and mouse embryonic stem cell-derived intestinal organoids

Article

作者: Şişli, Hatice Burcu ; Böke, Özüm Begüm ; Erdoğmuş, Özüm ; Sümer, Engin ; Doğan, Ayşegül ; Şenkal Turhan, Selinay ; Kül, Berke ; Bulut Okumuş, Ezgi

BACKGROUNDTumor modeling using organoids holds potential in studies of cancer development, enlightening both the intracellular and extracellular molecular mechanisms behind different cancer types, biobanking, and drug screening. Intestinal organoids can be generated in vitro using a unique type of adult stem cells which are found at the base of crypts and are characterized by their high Lgr5 expression levels.METHODS AND RESULTSIn this study, we successfully established intestinal cancer organoid models by using both the BALB/c derived and mouse embryonic stem cells (mESCs)-derived intestinal organoids. In both cases, carcinogenesis-like model was developed by using azoxymethane (AOM) treatment. Carcinogenesis-like model was verified by H&E staining, immunostaining, relative mRNA expression analysis, and LC/MS analysis. The morphologic analysis demonstrated that the number of generated organoids, the number of crypts, and the intensity of the organoids were significantly augmented in AOM-treated intestinal organoids compared to non-AOM-treated ones. Relative mRNA expression data revealed that there was a significant increase in both Wnt signaling pathway-related genes and pluripotency transcription factors in the AOM-induced intestinal organoids.CONCLUSIONWe successfully developed simple carcinogenesis-like models using mESC-based and Lgr5 + stem cell-based intestinal organoids. Intestinal organoid based carcinogenesi models might be used for personalized cancer therapy in the future.

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2022-06-16

·PRNewswire

Le Texas Cardiac Arrhythmia Institute du St. David's Medical Center a accueilli une conférence internationale sur les arythmies cardiaques complexes

AUSTIN, Texas, 16 juin 2022 /PRNewswire/ -- Les 2 et 3 juin 2022, le Texas Cardiac Arrhythmia Institute (TCAI) du St. David's Medical Center a accueilli son sixième symposium international sur les arythmies complexes, EPLive 2022. Cette année, plus de 1 250 personnes se sont inscrites, un nombre record, et plus de 150 y ont participé en personne à l'évènement. Les participants venaient du monde entier, notamment de Singapour, de Thaïlande, de Tunisie, d'Allemagne, de Corée et de Grèce. Parmi les participants figuraient des électrophysiologistes cardiaques pratiquant en clinique, des membres des diverses Sociétés d'électrophysiologie et des cardiologues généralistes qui s'intéressent au traitement des arythmies cardiaques complexes, un problème de santé où le cœur bat à un rythme irrégulier ou anormal. L'outil pédagogique principal a été la présentation de cas diffusés en direct du nouveau centre d'électrophysiologie de pointe du St. David's Medical Center et commentés par des d'experts. Les cas présentés en direct présentés lors d'EPLive 2022 mettaient en avant les nouvelles technologies mises au point par les médecins du TCAI, notamment l'électroporation irréversible, qui aide les patients souffrant d'arythmie cardiaque en utilisant des champs électriques contrôlés pour créer de minuscules lésions dans le cœur afin de bloquer les signaux électriques irréguliers, et ainsi réduire potentiellement le risque de dommages aux veines, artères ou nerfs du patient. « De la technologie de pointe qui a été dévoilée au nombre record d'inscriptions, il s'agit véritablement de notre EPLive le plus important à ce jour », a déclaré Andrea Natale, M.D., F.H.R.S., F.A.C.C., F.E.S.C., électrophysiologiste cardiaque, directeur médical exécutif du TCAI et directeur du cours EPLive. « EPLive joue un rôle de premier plan dans l'élargissement de la portée des options de traitement en électrophysiologie, ce qui, nous l'espérons, a un impact positif sur la vie des patients du monde entier. » EPLive a tenu quatre sessions consistant en une combinaison de cas diffusés en direct et enregistrés du TCAI et certains des plus grands centres du monde, dont : Arhythmia Center CardioInfantil Foundation (Colombie), Cardiovascular Center Brussels, Cleveland Clinic, Kansas City Heart Rhythm Institute, Liverpool Heart and Chest Hospital (Royaume-Uni), Mass General Hospital, Methodist Hospital (Houston, Texas), Montefiore Hospital (New York), Monzino Cardiac Center (Itay), Mt. Sinai Hospital (New York), Pacific Heart (Californie), University of Arkansas Medical Center, UCLA, University of Chicago Medicine, University of Colorado School of Medicine, University Hospital of Brussels, University of Pennsylvania, University of Texas Southwestern Medical Center, Vanderbilt University, Westside Regional Medical Center (Floride) et Yeditepe University (Turquie). Outre les démonstrations du Dr Natale, EPLive 2022 comprenait des présentations de plusieurs médecins du TCAI, dont le codirecteur du cours, Amin Al-Ahmad, M.D., ainsi que Shane Bailey, M.D. ; Mohamed Bassiouny, M.D. ; David Burkhardt, M.D. ; David Burkland, M.D. ; Robert Canby, M.D. ; Paul Coffeen, M.D. ; Joseph Gallinghouse, M.D. ; Brian Greet, M.D. ; Eric Hoenicke, M.D. ; Rodney Horton, M.D. ; Patrick Hranitzky, M.D. ; David Kessler, M.D. ; Javier Sanchez, M.D. ; Kamala Tamirisa, M.D. ; Senthil Thambidorai, M.D. ; David Tschopp, M.D. ; et Jason Zagrodsky, M.D. Lors de la conférence, les médecins ont reçu un maximum de 14 heures de Physician's Recognition Award Category 1 Credit™ de l'American Medical Association (AMA). Pour en savoir plus, consultez le site EP-Live.com. Contact pour les médias : Matt Grilli or Kat Griffith, ECP [email protected] ou [email protected] Téléphone : 630.800.9533 ou 512.797.4002. SOURCE Texas Cardiac Arrhythmia Institute at St. David’s Medical Center

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2022-06-16

·PRNewswire

Das Texas Cardiac Arrhythmia Institute am St. David's Medical Center veranstaltete eine internationale Konferenz über komplexe Herzrhythmusstörungen

AUSTIN, Texas, 16. Juni 2022 /PRNewswire/ -- Am 2. und 3. Juni 2022 veranstaltete das Texas Cardiac Arrhythmia Institute (TCAI) am St. David's Medical Center sein sechstes internationales Symposium über komplexe Herzrhythmusstörungen, EPLive 2022. In diesem Jahr hatten sich mehr als 1 250 Personen angemeldet, eine Rekordzahl, und mehr als 150 waren persönlich anwesend. Die Teilnehmer kamen aus allen Teilen der Welt, darunter Singapur, Thailand, Tunesien, Deutschland, Korea und Griechenland. Zu den Teilnehmern gehörten praktizierende klinische Herz-Elektrophysiologen, Elektrophysiologen in Ausbildung und allgemeine Kardiologen, die sich für die Behandlung komplexer Herzrhythmusstörungen interessieren - Erkrankungen, bei denen das Herz in einem unregelmäßigen oder anormalen Rhythmus schlägt. Das wichtigste Lehrmittel waren live übertragene Fälle aus dem neuen, hochmodernen Elektrophysiologiezentrum im St. David's Medical Center, die von Experten kommentiert wurden. Auf der EPLive 2022 wurden neue Technologien vorgestellt, bei denen Ärzte des TCAI Pionierarbeit geleistet haben, darunter die irreversible Elektroporation, die Patienten mit Herzrhythmusstörungen hilft, indem sie mithilfe kontrollierter elektrischer Felder winzige Narben im Herzen erzeugt, um unregelmäßige elektrische Signale zu blockieren und so möglicherweise das Risiko einer Schädigung der Venen, Arterien oder Nerven des Patienten zu verringern. „Von der vorgestellten Spitzentechnologie bis hin zu den Rekordzahlen bei den Anmeldungen war dies unsere bisher bedeutendste EPLive", sagte Andrea Natale, M.D., F.H.R.S., F.A.C.C., F.E.S.C., Herz-Elektrophysiologe und leitender medizinischer Direktor des TCAI sowie EPLive-Kursleiter. „EPLive spielt eine führende Rolle bei der Erweiterung der elektrophysiologischen Behandlungsmöglichkeiten, was sich hoffentlich positiv auf das Leben von Patienten weltweit auswirkt." EPLive umfasste vier Sitzungen, die aus einer Kombination von Live- und aufgezeichneten Fällen vom TCAI sowie von einigen der weltweit führenden Zentren bestanden: Arrhythmia Center CardioInfantil Foundation (Colombia), Cardiovascular Center Brussels, Cleveland Clinic, Kansas City Heart Rhythm Institute, Liverpool Heart and Chest Hospital (Vereinigtes Königreich), Mass General Hospital, Methodist Hospital (Houston, Texas), Montefiore Hospital (New York), Monzino Cardiac Center (Itay), Mt. Sinai Hospital (New York), Pacific Heart (Kalifornien), University of Arkansas Medical Center, UCLA, University of Chicago Medicine, University of Colorado School of Medicine, University Hospital of Brussels, University of Pennsylvania, University of Texas Southwestern Medical Center, Vanderbilt University, Westside Regional Medical Center (Florida) und Yeditepe University (Türkei). Zusätzlich zu den Demonstrationen von Dr. Natale bot EPLive 2022 Präsentationen von einer Reihe von TCAI-Ärzten, darunter der Co-Direktor des Kurses, Dr. Amin Al-Ahmad, sowie Shane Bailey, M.D.; Mohamed Bassiouny, M.D.; David Burkhardt, M.D.; David Burkland, M.D.; Robert Canby, M.D.; Paul Coffeen, M.D.; Joseph Gallinghouse, M.D.; Brian Greet, M.D.; Eric Hoenicke, M.D.; Rodney Horton, M.D.; Patrick Hranitzky, M.D.; David Kessler, M.D.; Javier Sanchez, M.D.; Kamala Tamirisa, M.D.; Senthil Thambidorai, M.D.; David Tschopp, M.D.; und Jason Zagrodsky, M.D. Ärzte erhielten auf der Konferenz maximal 14 PRA (Physician's Recognition Award) der American Medical Association (AMA) in der Kategorie 1 Credit™ Stunden. Weitere Informationen finden Sie unter EP-Live.com. Medienkontakt: Matt Grilli oder Kat Griffith, ECP [email protected] oder [email protected] 630.800.9533 oder 512.797.4002 Handys SOURCE Texas Cardiac Arrhythmia Institute at St. David’s Medical Center

2022-06-15

·PRNewswire

Instituto de Arritmia Cardíaca do Texas no St. David's Medical Center realizou conferência internacional sobre arritmias cardíacas complexas

AUSTIN, Texas, 15 de junho de 2022 /PRNewswire/ -- Nos dias 2 e 3 de junho de 2022, o Instituto de Arritmia Cardíaca do Texas (TCAI) no St. David's Medical Center realizou seu sexto simpósio internacional sobre arritmias complexas, o EPLive 2022. O evento deste ano teve o número recorde de mais de 1.250 pessoas inscritas, com mais de 150 delas participando presencialmente. Havia participantes de todo o mundo, incluindo Singapura, Tailândia, Tunísia, Alemanha, Coreia e Grécia. Entre os participantes estavam eletrofisiologistas cardíacos clínicos, eletrofisiologistas e cardiologistas em geral que se interessem por tratar arritmias cardíacas complexas, uma doença em que o coração bate em um ritmo irregular ou anormal. A principal ferramenta de ensino foram casos ao vivo transmitidos do novo Centro de Eletrofisiologia de última geração no St. David 's Medical Center, com comentários de especialistas. Os casos vivos tratados durante o EPLive 2022 apresentaram novas tecnologias pioneiras usadas pelos médicos do TCAI, incluindo eletroporação irreversível, que ajuda pacientes com arritmia cardíaca utilizando campos elétricos controlados para criar pequenas cicatrizes no coração a fim de bloquear os sinais elétricos irregulares e, assim, reduzir potencialmente o risco de danos às veias, artérias ou aos nervos de um paciente. "Desde a tecnologia de ponta que foi apresentada até o número recorde de inscritos, este foi realmente nosso EPLive mais importante até o momento", disse Andrea Natale, M.D., F.H.R.S., F.A.C.C., F.E.S.C., eletrofisiologista cardíaco e diretor médico executivo do TCAI e diretor do curso EPLive. "O EPLive desempenha um papel de liderança na expansão do escopo das opções de tratamento da eletrofisiologia, e esperamos que ele tenha um impacto positivo na vida de pacientes em todo o mundo." O EPLive apresentou quatro sessões, que consistiram em uma combinação de casos ao vivo e registrados do TCAI, bem como de alguns dos principais centros do mundo, como Arrhythmia Center CardioInfantil Foundation (Colômbia), Cardiovascular Center Brussels, Cleveland Clinic, Kansas City Heart Rhythm Institute, Liverpool Heart and Chest Hospital (Reino Unido), Mass General Hospital, Methodist Hospital (Houston, Texas), Montefiore Hospital (Nova York), Monzino Cardiac Center (Itália), Mt. Sinai Hospital (Nova York), Pacific Heart (Califórnia), University of Arkansas Medical Center, UCLA, University of Chicago Medicine, University of Colorado School of Medicine, University Hospital of Brussels, University of Pennsylvania, University of Texas Southwestern Medical Center, Vanderbilt University, Westside Regional Medical Center (Flórida) e Yeditepe University (Turquia). Além das demonstrações feitas pelo Dr. Natale, o EPLive contou com apresentações de vários médicos do TCAI, como Amin Al-Ahmad, M.D., codiretor de cursos, e Shane Bailey, M.D.; Mohamed Bassiouny, M.D.; David Burkhardt, M.D.; David Burkland, M.D.; Robert Canby, M.D.; Paul Coffeen, M.D.; Joseph Gallinghouse, M.D.; Brian Greet, M.D.; Eric Hoenicke, M.D.; Rodney Horton, M.D.; Patrick Hranitzky, M.D.; David Kessler, M.D.; Javier Sanchez, M.D.; Kamala Tamirisa, M.D.; Senthil Thambidorai, M.D.; David Tschopp, M.D.; e Jason Zagrodzky, M.D. Os médicos receberam, no máximo, 14 horas de Physician's Recognition Award (PRA) Category 1 Credit™ da Associação Médica Americana (AMA) na conferência. Para mais informações, acesse EP-Live.com. Contato para a imprensa: Matt Grilli ou Kat Griffith, ECP [email protected] ou [email protected] 630.800.9533 ou 512.797.4002 (celulares) FONTE Texas Cardiac Arrhythmia Institute at St. David’s Medical Center SOURCE Texas Cardiac Arrhythmia Institute at St. David’s Medical Center

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