Deciphering the Role of a Low Protein Diet in Disease Control in Acromegalic Patients
Since protein and AAs are master regulator of GH and IGF-I secretion, we hypothesized that a low protein diet could reduce GH and IGF-I levels in acromegalic patients in addition to conventional therapy. Furthermore, we aim to explore metabolomic, microbiota, and micro-vesicle fingerprints of GH hypersecretion during conventional therapy and after a low protein diet
Susceptibility to Infectious Diseases in Obesity: an Endocrine, Translational, Sociological Evaluation
The role of intestinal microbiota is becoming ever more important in the context of obesity, type II diabetes (T2D), and infectious disorders as represented by the emerging discipline "therapeutic microbiology". The gut microbiota is strictly interconnected with obesity and T2D playing also an important role in immune system regulation.
Obesity and diabetes can lead to chronic inflammation, which results in the secretion of pro-inflammatory cytokines like IL-6, IL-1, and TNF-alpha, causing immune system alteration which predisposes patients with obesity and T2D to chronic infections. Therefore, the principal aim of the study is to investigate changes in gut microbiota composition between patients with chronic infections or not, so as to attribute to specific phyla the formation of the infections in these patients.
LEft Bundle branchArea Pacing to Avoid Pacing-induced CARdiomyopathy: the LEAP-CAR Prospective, Randomized Trial
LEAP-CAR will evaluate the benefit of left bundle branch area pacing (LBBAP), comparing to conventional right ventricular pacing (RVP), in preventing pacing-induced cardiomyopathy (PICM) in patients undergoing pacemaker implant for advanced (2° or 3° degree) atrioventricular block, with baseline left ventricular ejection fraction (LVEF) >45%.
LEAP-CAR is a randomized, prospective, double blind clinical trial.
100 项与 Azienda Ospedaliero Universitaria Policlinico 相关的临床结果
0 项与 Azienda Ospedaliero Universitaria Policlinico 相关的专利(医药)
European Journal of Contraception & Reproductive Health Care
We don′t have elements to scare women who use oral contraceptives based on nomegestrol or chlormadinone about the risk of meningioma. Let′s be careful and honest!
作者: Grandi, Giovanni ; Marani, Gianluca ; Facchinetti, Fabio ; Bahamondes, Luis
100 项与 Azienda Ospedaliero Universitaria Policlinico 相关的药物交易
100 项与 Azienda Ospedaliero Universitaria Policlinico 相关的转化医学